Capture of Ligand-DNA Crosslinks and Isolation of Affinity-purified DNA
7:52
Results: COSMIC Indentifies Genome-wide Binding Events of Polyamides
9:21
Conclusion
필기록
The overall goal of this procedure is to determine the genome-wide binding profiles of polyamides and other DNA-targetting small molecules in cells. This method can help advance the field of drug DNA chemistry by using the genome to guide the desi
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Identifying the direct targets of genome-targeting molecules remains a major challenge. To understand how DNA-binding molecules engage the genome, we developed a method that relies on crosslinking of small molecules to isolate chromatin (COSMIC).