Opening the Pial Membrane and Insering the Subpial Needle for AAV9 Delivery
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Results: GFP-expression in Spine Parenchyma and Brain Following Subpial AAV9 Delivery
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Conclusion
Transcripción
The overall goal of this subpial AAV9 delivery technique is to achieve a potent spinal parenchymal transgene expression throughout the entire length of spinal chord in adult mice. This method can facilitate studies targeted to manipulate spinal ge
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The goal of the present study was to develop and validate the potency and safety of spinal adeno-associated virus 9 (AAV9)-mediated gene delivery by using a novel subpial gene delivery technique in adult mice.