May 11th, 2018
•We have engineered the capsid protein of hepatitis E virus as a theranostic nanoparticle (HEVNP). HEVNP self-assembles into a stable icosahedral cage in mucosal delivery. Here, we describe the modification of HEVNPs for tumor targeting by mutating surface-exposed residues to cysteines, which conjugate synthetic ligands that specifically bind tumor cells.
Tags
Videos relacionados
Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs
Soft Lithographic Functionalization and Patterning Oxide-free Silicon and Germanium
Harvesting Murine Alveolar Macrophages and Evaluating Cellular Activation Induced by Polyanhydride Nanoparticles
Analyzing Cellular Internalization of Nanoparticles and Bacteria by Multi-spectral Imaging Flow Cytometry
High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Making Conjugation-induced Fluorescent PEGylated Virus-like Particles by Dibromomaleimide-disulfide Chemistry
Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
ACERCA DE JoVE
Copyright © 2024 MyJoVE Corporation. Todos los derechos reservados