Results: Effect of rFVIII After Intravenous Administration
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Conclusion
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Tail bleeding models can be important tools to assess pharmacological effects of hemostatic compounds in vivo to ensure reproducibility between experiments. Compared to other sensitive bleeding models, our model uses blood loss and bleeding time a
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The refined tail vein transection (TVT) bleeding model in anesthetized mice is a sensitive in vivo method for the assessment of hemophilic bleeding. This optimized TVT bleeding model uses blood loss and bleeding time as endpoints, refining other models and avoiding death as an endpoint.