Interview: HIV-1 Proviral DNA Excision Using an Evolved Recombinase

0:59

What are limitations of today's antiretroviral therapies

1:41

Excision of proviral DNA. Targeting LTR specific sequences.

3:39

Addressing the problem of multiple HIV isolates.

4:35

Generation of site-specific Tre recombinase via directed molecular evolution.

5:49

Delivery of Tre recombinase, HIV-1 proviral DNA excision, and elimination of HIV-1 viruses.

6:39

Open questions.

8:21

Towards a clinical application.