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Interview: HIV-1 Proviral DNA Excision Using an Evolved Recombinase

DOI :

10.3791/793-v

June 16th, 2008

June 16th, 2008

11,296 Views

1Department of Cell Biology and Virology, Heinrich-Pette-Institute for Experimental Virology and Immunology, University of Hamburg

Current HIV-1 strategies act to suppress the viral life cycle but do not effectively eradicate infection. Here, we demonstrate that an engineered recombinase can efficiently excise integrated HIV-1 proviral DNA from the genome of infected cells.

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