Battelle Center for Mathematical Medicine
CURRICULUM VITAE
Name: Ning Li
Present Status: Professor
Present address: Division of Life Science
The Hong Kong University of Science and Technology
Clear Water Bay, Kowloon, Hong Kong SAR.
Tel: 852-358-7335;
Fax: 852-358-1559.
E-mail: boningli@.ust.hk
Website http://life-sci.ust.hk/team/ning-li/
Education
1989 Ph. D University of Washington, Seattle, WA. USA
Subject area : plant molecular biology and biochemistry
Professional positions
1993 – present Professor, Associate Professor and Assistant Professor
Division of Life Science, HKUST, Hong Kong SAR, China.
1989 – 1993 Research Associate, USDA/ARS/PSI, Plant Molecular Biology Laboratory, Beltsville, MD. USA.
1989 Postdoctoral Fellow, Department of Biochemistry, University of Washington, Seattle, WA. USA.
Honorary positions
2017 – present Professor of Energy Institute, and Institute for the Environment, HKUST
2013 – present Professor of Shenzhen Research Institute, HKUST
2016 – 2019 Adjunct Senior Research Fellow of Chinese Academy of Tropical Agricultural Science
2012-2013 Chair of Gordon Research Conference on the PTM network
2011 Director of the Croucher Advanced Study Institute
2010-2012 Director of CAS-Croucher and HKUST Joint lab
2006 – 2011 Adjunct Professor of Lanzhou University, Lanzhou, China.
2005 Scientist in Salk Institute for Biological Studies, San Diego, USA.
1999-present Adjunct Senior Research Fellow of Institute of Botany, Chinese Academy of Sciences, Beijing, China
2001- present Adjunct Senior Research Fellow of Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
2001- present Adjunct Senior Research Fellow of Jiangshu Institute of Botany and Zhong Shan Botanic Garden, Chinese Academy of Sciences, Nanjing, China.
2001- 2005 Adjunct Professor of Zhongshan University, Guangzhou, China.
Research Achievements
1. Establishment and development of MS-based quantitative in vivo interactomics, IPQCX-MS.
2. Establishment of dimethyl-labeling-based quantitative PTM proteomics approach and discovery of ethylene-regulated acetylproteome.
3. Establishment of SILIA-based quantitative PTM proteomic and molecular genetic analysis of Arabidopsis touch response (thigmomorphogenesis) and discovery of TREPHs (touch-regulated phosphoproteins) playing a key role in plant mechano-signaling.
4. Functional and quantitative PTM proteomics analysis of EIN2- and EIN3/EIL1-independent phosphor-relay pathways and discovery of the dual-and-opposing (Yin-Yang) mode of action for ethylene regulation as well as the roles of phosphorylated water channel protein PIP2;1 isoform and Ser62-phosphorylated ERF110 in ethylene response.
5. Identification of novel ethylene-regulated time-dependent phosphoproteins and putative CTR1 substrates using SILIA-based quantitative and differential phosphoproteomics.
6. Establishment of SILIA-based absolute quantitation of isoform of post-translationally modified redox proteins (OxNSIL), which will provide practical means to study the redox state on redox-regulated PTM proteins.
7. Establishment of SILIA-based absolute quantitation of isoform of post-translationally modified (PTM) proteins (AQUIP), which will provide practical means to study “combinatorial PTM code” on PTM proteins.
8. Establishment of 15N stable isotope labeling in Arabidopsis (SILIA) protocol for in vivo quantitation of protein PTM, which will provide a large scale of high-throughput data for construction of phosphor-relay-mediated cell signaling network in plants.
9. Discovery of cis-cinnamic acid (cis-form) being a new class of growth regulator affecting many aspects of plant growth and development ranging from seed germination, seedling development, flowering and fruit ripening, leading to the molecular cloning of cis-cinnamate-inducible genes (ZCE1) using label-free differential proteomics approach and the map-based cloning of a cis-phenylpropanoid response (CPAR) genes.
10. Molecular breeding of transgenic citrus plants over-expressing chilling-inducible antisense ACC synthase gene.
11. The application of ethylene as a novel gaseous reporter in animal cells.
12. Improvement of tomato fruit quality through genetic engineering of SAM decarboxylase.
A. Five most representative journal publications in recent 5 years
1. Wang, K., Yang, Z., Qing, D., Ren, F., Liu, S., Zheng, Q., Liu, J., Zhang, W., Dai, C., Wu, M., Chehab, E.W., Braam, J., Li, Ning*. (2018). Quantitative and functional posttranslational modification proteomics reveals that TREPH1 plays a role in plant touch-delayed bolting. Proceedings of the National Academy of Sciences. 115, 115, 10830-10835.
2. Liu, SC, Yu, FC, Yang Z, Wang T, Xiong, H Chang, C, Yu, WC*, and Ning Li* (2018) Establishment of dimethyl labelling-based quantitative acetylproteomics in Arabidopsis. Mol Cell Proteomics. 17, 1010-1027.
3. Zhu, XL, Yu, FC, Yang, Zhu, Liu, SC, Dai C, Lu, XY, Liu, CY, Yu, WC* and Ning Li* (2016) In planta Chemical Cross-linking and Mass Spectrometry Analysis of Protein Structure and Interaction in Arabidopsis. Proteomics. 16, 1915-1927.
4. Liu, SC, Yu, FC, Hu, Q, Wang, TL, Yu, LJ, Du, SW, Yu, WC* and Ning Li*. (2018) Development of in Planta Chemical Cross-Linking-Based Quantitative Interactomics in Arabidopsis. J. Proteome Research. 17, 3195-3213.
5. Zhu Yang, Guangyu Guo, Manyu Zhang, Claire Y. Liu, Qin Hu, others and Ning Li* (2013) Stable Isotope Metabolic Labeling-Based Quantitative Phosphoproteomic Analysis of Arabidopsis Mutants Reveals Ethylene-Regulated Time-Dependent Phosphoproteins and Putative Substrates of CONSTITUTIVE TRIPLE RESPONSE 1 Kinase. Molecular and Cellular Proteomics. 12: 3559-3582.
B. Five representative journal publications beyond the recent 5 years
1. Zhu, L; Liu, D; Li, Y and others, Ning Li* (2013) Functional Phosphoproteomic Analysis Reveals That a Serine-62-Phosphorylated Isoform of Ethylene Response Factor110 Is Involved in Arabidopsis Bolting. Plant Physiology. 161, 904-917.
2. Li, H, Wong WS, Guo, HW, Ecker, J and Ning Li* (2009) Proteomics. 9, 1646-1661.
3. Chen, G, Bi YR and Ning Li (2005) The Plant Journal. 41, 363-375.
4. Mehta, RA,Cassol, T, Li,Ning, Ali,N , Handa,AK and Mattoo, AK (2002) Nature Biotechnology. 20, 613-618.
5. Huai Q , others, Li, Ning and Ke, HM . (2001). J. Biol. Chem. 276, 38210-38216.
The multiple roles of conserved arginine 286 of 1-aminocyclopropane-1-carboxylate synthase. Coenzyme binding, substrate binding, and beyond.
Plant physiology Nov, 1999 | Pubmed ID: 10557240
[A method for rapid and early diagnosis of trisomy 21 using molecular techniques].
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao Jan, 2002 | Pubmed ID: 12599450
Condyloma acuminatum and human papilloma virus infection in the oral mucosa of children.
Pediatric dentistry Mar-Apr, 2003 | Pubmed ID: 12723841
Effects of n-3 fatty acid, fructose-1,6-diphosphate and glutamine on mucosal cell proliferation and apoptosis of small bowel graft after transplantation in rats.
World journal of gastroenterology Jun, 2003 | Pubmed ID: 12800249
[The effect of cryotreat on tensile properties of medium melting-point and high melting-point castable alloy].
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology Jun, 2004 | Pubmed ID: 15293479
EGY1 encodes a membrane-associated and ATP-independent metalloprotease that is required for chloroplast development.
The Plant journal : for cell and molecular biology Feb, 2005 | Pubmed ID: 15659096
[The design of Co-Cr-Mo alloy combining the framework with porcelain fused to metal restorations and determination of the mechanical properties].
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology Feb, 2005 | Pubmed ID: 15804011
[The study of clinical application of high intensity focused ultrasound in non-invasive therapy for liver cancer].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition May, 2005 | Pubmed ID: 15931887
The practical value of applying chemical biliary duct embolization to chemical hepatectomy for treatment of hepatolithiasis.
The Journal of surgical research Aug, 2005 | Pubmed ID: 15936771
Tyr152 plays a central role in the catalysis of 1-aminocyclopropane-1-carboxylate synthase.
Journal of experimental botany Aug, 2005 | Pubmed ID: 15983009
A preliminary study of applying chemical biliary duct embolization to chemical hepatectomy in rats.
Digestive diseases and sciences Jun, 2005 | Pubmed ID: 15986875
Primary neurofibroma of the common bile duct as an unusual cause of obstructive jaundice: a case report.
Digestive diseases and sciences Jun, 2005 | Pubmed ID: 15986876
Application of 3' untranslated region (UTR) sequence-based amplified polymorphism analysis in the rapid authentication of Radix astragali.
Journal of agricultural and food chemistry Nov, 2005 | Pubmed ID: 16248552
[A systematic evaluation of randomized controlled trials for acupuncture and moxibustion treatment of insomnia].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Jan, 2005 | Pubmed ID: 16309145
Study of cis-cinnamic acid in Arabidopsis thaliana.
Plant physiology and biochemistry : PPB / Société française de physiologie végétale Oct-Nov, 2005 | Pubmed ID: 16310363
Effectiveness of chemical biliary duct embolization for chemical hepatectomy.
Journal of gastroenterology and hepatology May, 2006 | Pubmed ID: 16704540
Preliminary study of chemical bile duct embolization to treat hepatolithiasis in rabbits.
Journal of gastroenterology and hepatology Jun, 2006 | Pubmed ID: 16724984
[Effect of rolling needle therapy on quality of life in the patient of non-organic chronic insomnia: a randomized controlled trial].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Jul, 2006 | Pubmed ID: 16903592
Feasibility and effectiveness of chemical bile duct embolization for chemical hepatectomy: a preliminary study.
Hepatobiliary & pancreatic diseases international : HBPD INT Nov, 2006 | Pubmed ID: 17085344
[Preliminary study on training of resident physicians and special physicians of acupuncture-moxibustion].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Feb, 2007 | Pubmed ID: 17370484
Clinical application prospects of gastric pacing for treating postoperative gastric motility disorders.
Journal of gastroenterology and hepatology Dec, 2007 | Pubmed ID: 17593227
[Discussion on randomized controlled trials about clinical researches of acupuncture and moxibustion medicine].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Jul, 2007 | Pubmed ID: 17722836
Giant submucosal lipoma located in the descending colon: a case report and review of the literature.
World journal of gastroenterology Nov, 2007 | Pubmed ID: 17948945
[Bibliometric analysis of literature on acupuncture and moxibustion for treatment of knee osteoarthritis].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Nov, 2007 | Pubmed ID: 18085154
EGY1 plays a role in regulation of endodermal plastid size and number that are involved in ethylene-dependent gravitropism of light-grown Arabidopsis hypocotyls.
Plant molecular biology Mar, 2008 | Pubmed ID: 18097640
Treatment of hepatolithiasis by chemical bile duct embolization: report on 2 cases.
Surgical laparoscopy, endoscopy & percutaneous techniques Feb, 2008 | Pubmed ID: 18287993
[Clinical and qualitative research on acu-moxibustion: considerations on acupuncture clinical trail methods].
Zhen ci yan jiu = Acupuncture research Jun, 2008 | Pubmed ID: 18807727
A hierarchical zero-inflated log-normal model for skewed responses.
Statistical methods in medical research Jun, 2011 | Pubmed ID: 18815163
Proliferating cell nuclear antigen shRNA treatment attenuates chronic proliferative cholangitis in rats.
Journal of gastroenterology and hepatology May, 2009 | Pubmed ID: 19032457
[Observation on therapeutic effect of electroacupuncture at Chengshan (BL 57) and Changqiang (GV 1) on hemorrhoidal pain].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Nov, 2008 | Pubmed ID: 19055280
Treatment of chronic proliferative cholangitis with c-myc shRNA.
World journal of gastroenterology Jan, 2009 | Pubmed ID: 19115473
Biliary papillomatosis: analysis of 18 cases.
Chinese medical journal Dec, 2008 | Pubmed ID: 19187604
Phosphoproteomic analysis of ethylene-regulated protein phosphorylation in etiolated seedlings of Arabidopsis mutant ein2 using two-dimensional separations coupled with a hybrid quadrupole time-of-flight mass spectrometer.
Proteomics Mar, 2009 | Pubmed ID: 19253305
Acupuncture for Bell's palsy.
Journal of alternative and complementary medicine (New York, N.Y.) Jul, 2009 | Pubmed ID: 19500005
The needle-rolling therapy for treatment of non-organic chronic insomnia in 90 cases.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Mar, 2009 | Pubmed ID: 19514183
Clinical prospect of applying the chemical bile duct embolization to achieve a chemical hepatectomy in the treatment of highly selected hepatolithiasis.
Surgical laparoscopy, endoscopy & percutaneous techniques Jun, 2009 | Pubmed ID: 19542840
[Survey study of conditions of patients with acute stroke seeking for acupuncture treatment].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Dec, 2009 | Pubmed ID: 20088423
Epidermal growth factor receptor as a target for anti-proliferative treatment of proliferative cholangitis in hepatolithiasis.
The Journal of surgical research Mar, 2011 | Pubmed ID: 20097367
[Acupuncture for the lower extremity spasm induced by spinal injury: random controlled trial of single case].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Jun, 2010 | Pubmed ID: 20578385
[Effect of glucagon-like peptide-2 (GLP-2) on intestinal barrier function in bile duct ligated rats].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition May, 2010 | Pubmed ID: 20629325
[Clinical observation of urinary retention after hemorrhoid and fistula operation treated with suspen-ding moxibustion].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Jul, 2010 | Pubmed ID: 20862941
[Observation on therapeutic effect of electroacupuncture at Tianshu (ST 25) with deep needling technique on functional constipation].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Sep, 2010 | Pubmed ID: 20886786
Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells.
Cancer research Nov, 2010 | Pubmed ID: 21045151
Cis-cinnamic acid-enhanced 1 gene plays a role in regulation of Arabidopsis bolting.
Plant molecular biology Mar, 2011 | Pubmed ID: 21298397
Relative and accurate measurement of protein abundance using 15N stable isotope labeling in Arabidopsis (SILIA).
Phytochemistry Jul, 2011 | Pubmed ID: 21315391
Motif-All: discovering all phosphorylation motifs.
BMC bioinformatics Feb, 2011 | Pubmed ID: 21342552
[Randomized controlled trial on the effect of transcutaneous electrical nerve stimulation at Dingchuan (EX-B1) on the pulmonary function of patients with COPD at acute stage].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Feb, 2011 | Pubmed ID: 21442803
[Effects of electroacupuncture at Tianshu (ST25) on pro- and anti-inflammatory cytokines in rats with severe acute pancreatitis].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine Jun, 2011 | Pubmed ID: 21669171
[Effect of electroacupuncture on serum proinflammatory cytokine levels and pancreatic nuclear factor kappa-b expression in acute pancreatitis rats].
Zhen ci yan jiu = Acupuncture research Aug, 2011 | Pubmed ID: 21942181
[Study on corrosion resistance of three non-noble porcelain alloys].
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology Oct, 2011 | Pubmed ID: 22165115
[The effect of solid phase transformation on the metal-ceramic compatibility of Co-Cr alloy].
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology Dec, 2011 | Pubmed ID: 22332563
Absolute quantitation of isoforms of post-translationally modified proteins in transgenic organism.
Molecular & cellular proteomics : MCP Aug, 2012 | Pubmed ID: 22442259
Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer.
The Journal of biological chemistry May, 2012 | Pubmed ID: 22467868
[Double-center randomized controlled trial on post-stroke shoulder pain treated by electroacupuncture combined with Tuina].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Feb, 2012 | Pubmed ID: 22493908
Quantitative measurement of phosphopeptides and proteins via stable isotope labeling in Arabidopsis and functional phosphoproteomic strategies.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22576083
The effect of high intensity focused ultrasound on vascular endothelial growth factor and microvessel density in rabbit V-X2 hepatocellular carcinoma models.
Hepato-gastroenterology Jan-Feb, 2013 | Pubmed ID: 22784938
Keratin K18 increases cystic fibrosis transmembrane conductance regulator (CFTR) surface expression by binding to its C-terminal hydrophobic patch.
The Journal of biological chemistry Nov, 2012 | Pubmed ID: 23045527
Circulating and local renin-angiotensin-aldosterone system express differently in atrial fibrillation patients with different types of mitral valvular disease.
Journal of the renin-angiotensin-aldosterone system : JRAAS Sep, 2013 | Pubmed ID: 23077077
Therapeutic effect of acupuncture and massage for shoulder-hand syndrome in hemiplegia patients: a clinical two-center randomized controlled trial.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Sep, 2012 | Pubmed ID: 23297553
Dendronized heparin-doxorubicin conjugate based nanoparticle as pH-responsive drug delivery system for cancer therapy.
Biomaterials Mar, 2013 | Pubmed ID: 23298778
Quantitation, networking, and function of protein phosphorylation in plant cell.
Frontiers in plant science , 2012 | Pubmed ID: 23316209
Therapeutic effects of electroacupuncture at ST36 acupoint on sodium-taurocholate-induced severe acute pancreatitis.
Chinese journal of integrative medicine Sep, 2014 | Pubmed ID: 23893236
[Influence of acupuncture and moxibustion on defecation in postoperative patients of anal fissure: a randomized controlled trial].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Jun, 2013 | Pubmed ID: 23967636
[A randomized controlled clinical trial for acupuncture stimulation of Neiguan (PC 6) to prevent postoperative nausea and vomiting].
Zhen ci yan jiu = Acupuncture research Jun, 2013 | Pubmed ID: 24006673
Stable isotope metabolic labeling-based quantitative phosphoproteomic analysis of Arabidopsis mutants reveals ethylene-regulated time-dependent phosphoproteins and putative substrates of constitutive triple response 1 kinase.
Molecular & cellular proteomics : MCP Dec, 2013 | Pubmed ID: 24043427
[Influence on microstructure of dental zirconia ceramics prepared by two-step sintering].
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology Oct, 2013 | Pubmed ID: 24298802
A chemically standardized extract of Ziziphus jujuba fruit (Jujube) stimulates expressions of neurotrophic factors and anti-oxidant enzymes in cultured astrocytes.
Phytotherapy research : PTR Nov, 2014 | Pubmed ID: 25066116
Amphiphilic peptide dendritic copolymer-doxorubicin nanoscale conjugate self-assembled to enzyme-responsive anti-cancer agent.
Biomaterials Nov, 2014 | Pubmed ID: 25145854
Electroacupuncture for the prevention of postoperative gastrointestinal dysfunction in patients undergoing vascular surgery under general anesthesia: study protocol for a prospective practical randomized controlled trial.
Journal of integrative medicine Nov, 2014 | Pubmed ID: 25412669
Effect and safety of deep needling and shallow needling for functional constipation: a multicenter, randomized controlled trial.
Medicine Dec, 2014 | Pubmed ID: 25526462
Optimizing the compatibility of paired-herb in an ancient Chinese herbal decoction Kai-Xin-San in activating neurofilament expression in cultured PC12 cells.
Journal of ethnopharmacology Mar, 2015 | Pubmed ID: 25560671
The volatile oil of Nardostachyos Radix et Rhizoma induces endothelial nitric oxide synthase activity in HUVEC cells.
PloS one , 2015 | Pubmed ID: 25643147
Reestablishment of active immunity against HBV graft reinfection after liver transplantation for HBV-related end stage liver disease.
Journal of immunology research , 2014 | Pubmed ID: 25759834
Calycosin orchestrates the functions of Danggui Buxue Tang, a Chinese herbal decoction composing of Astragali Radix and Angelica Sinensis Radix: An evaluation by using calycosin-knock out herbal extract.
Journal of ethnopharmacology Jun, 2015 | Pubmed ID: 25796405
Acupuncture efficacy on ischemic stroke recovery: multicenter randomized controlled trial in China.
Stroke May, 2015 | Pubmed ID: 25873601
Absolute quantitation of protein posttranslational modification isoform.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25930697
Risk Factors for Postoperative Retention After Hemorrhoidectomy: A Cohort Study.
Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates Nov-Dec, 2015 | Pubmed ID: 25974011
Effects of acupuncture at ST25 on inflammatory mediators and nuclear factor κB activation in a rat model of severe acute pancreatitis.
Acupuncture in medicine : journal of the British Medical Acupuncture Society Aug, 2015 | Pubmed ID: 25979864
Efficacy of electroacupuncture in the treatment of functional constipation: A randomized controlled pilot trial.
Chinese journal of integrative medicine Jun, 2015 | Pubmed ID: 26063319
Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture.
Journal of virology Oct, 2015 | Pubmed ID: 26246576
Quantitative and Functional Phosphoproteomic Analysis Reveals that Ethylene Regulates Water Transport via the C-Terminal Phosphorylation of Aquaporin PIP2;1 in Arabidopsis.
Molecular plant Jan, 2016 | Pubmed ID: 26476206
Associations between the codon 72 polymorphism of the TP53 gene and the risk of recurrent implantation failure.
The journal of obstetrics and gynaecology research Feb, 2016 | Pubmed ID: 26555776
Fast Simultaneous Determination of 13 Nucleosides and Nucleobases in Cordyceps sinensis by UHPLC-ESI-MS/MS.
Molecules (Basel, Switzerland) Dec, 2015 | Pubmed ID: 26690105
An improved substrate cocktail for assessing direct inhibition and time-dependent inhibition of multiple cytochrome P450s.
Acta pharmacologica Sinica May, 2016 | Pubmed ID: 27063220
In planta chemical cross-linking and mass spectrometry analysis of protein structure and interaction in Arabidopsis.
Proteomics 07, 2016 | Pubmed ID: 27198063
ECL: an exhaustive search tool for the identification of cross-linked peptides using whole database.
BMC bioinformatics May, 2016 | Pubmed ID: 27206479
FAT10 Is Critical in Influenza A Virus Replication by Inhibiting Type I IFN.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2016 | Pubmed ID: 27354218
Evaluation of metal-ceramic bond characteristics of three dental Co-Cr alloys prepared with different fabrication techniques.
The Journal of prosthetic dentistry Dec, 2016 | Pubmed ID: 27460313
Acupuncture for Chronic Severe Functional Constipation: A Randomized Trial.
Annals of internal medicine Dec, 2016 | Pubmed ID: 27618593
PIPI: PTM-Invariant Peptide Identification Using Coding Method.
Journal of proteome research 12, 2016 | Pubmed ID: 27748123
A facile one-pot oxidation-assisted dealloying protocol to massively synthesize monolithic core-shell architectured nanoporous copper@cuprous oxide nanonetworks for photodegradation of methyl orange.
Scientific reports 11, 2016 | Pubmed ID: 27830720
An antimicrobial peptide with an aggregation-induced emission (AIE) luminogen for studying bacterial membrane interactions and antibacterial actions.
Chemical communications (Cambridge, England) Mar, 2017 | Pubmed ID: 28078346
Enzyme-Sensitive and Amphiphilic PEGylated Dendrimer-Paclitaxel Prodrug-Based Nanoparticles for Enhanced Stability and Anticancer Efficacy.
ACS applied materials & interfaces Mar, 2017 | Pubmed ID: 28112512
Acupuncture for acute moderate thalamic hemorrhage: randomized controlled trial study protocol.
BMC complementary and alternative medicine Feb, 2017 | Pubmed ID: 28202067
Molecular cloning and characterization of kiss1 in Brandt's voles (Lasiopodomys brandtii).
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology Jun, 2017 | Pubmed ID: 28427900
Effect of Electroacupuncture on Urinary Leakage Among Women With Stress Urinary Incontinence: A Randomized Clinical Trial.
JAMA 06, 2017 | Pubmed ID: 28655016
The First Nationwide Multicenter Prevalence Study of Germline BRCA1 and BRCA2 Mutations in Chinese Ovarian Cancer Patients.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 10, 2017 | Pubmed ID: 28692638
Uptake, Distribution, and Bioimaging Applications of Aggregation-Induced Emission Saponin Nanoparticles in Arabidopsis thaliana.
ACS applied materials & interfaces 08, 2017 | Pubmed ID: 28799742
Exhaustively Identifying Cross-Linked Peptides with a Linear Computational Complexity.
Journal of proteome research 10, 2017 | Pubmed ID: 28825304
Novelty application of multi-omics correlation in the discrimination of sulfur-fumigation and non-sulfur-fumigation Ophiopogonis Radix.
Scientific reports 08, 2017 | Pubmed ID: 28855686
The long-term effect of acupuncture for patients with chronic tension-type headache: study protocol for a randomized controlled trial.
Trials Oct, 2017 | Pubmed ID: 28974247
[A Randomized Controlled Clinical Trial for Electroacupuncture Treatment of Post-surgical Gastrointestinal Dysfunction in Patients Undergoing Laparotomy].
Zhen ci yan jiu = Acupuncture research Oct, 2016 | Pubmed ID: 29071949
[Observation on the Efficacy of Electroacupuncture for Functional Constipation].
Zhen ci yan jiu = Acupuncture research Jun, 2017 | Pubmed ID: 29071984
Cloning and expression characterization in hypothalamic Dio2/3 under a natural photoperiod in the domesticated Brandt's vole (Lasiopodomys brandtii).
General and comparative endocrinology 04, 2018 | Pubmed ID: 29154946
Three-Dimensional Superresolution Imaging of the FtsZ Ring during Cell Division of the Cyanobacterium .
mBio 11, 2017 | Pubmed ID: 29162705
[Electroacupuncture for severe acute pancreatitis accompanied with paralytic ileus:a randomized controlled trial].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Nov, 2016 | Pubmed ID: 29231293
[Improving the researchers' compliance and the quality of clinical study on acupuncture and moxibustion:thoughts on the role conflict between doctors and researchers].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Jun, 2016 | Pubmed ID: 29231447
[Clinical observation of gastrointestinal dysfunction after vascular surgery prevented by electroacupuncture].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Oct, 2016 | Pubmed ID: 29231523
Acupuncture for chronic prostatitis/chronic pelvic pain syndrome: study protocol for a randomized controlled trial.
Trials Dec, 2017 | Pubmed ID: 29273095
Vancomycin-assisted green synthesis of reduced graphene oxide for antimicrobial applications.
Journal of colloid and interface science Mar, 2018 | Pubmed ID: 29316529
Temperature-induced surface reconstruction and interface structure evolution on ligament of nanoporous copper.
Scientific reports Jan, 2018 | Pubmed ID: 29323159
[Therapeutic effect observation of chronic knee joint pain assisted with the central-square needling technique of the thumb-tack needles].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Oct, 2017 | Pubmed ID: 29354972
Establishment of Dimethyl Labeling-based Quantitative Acetylproteomics in Arabidopsis.
Molecular & cellular proteomics : MCP 05, 2018 | Pubmed ID: 29440448
Tmem30a Plays Critical Roles in Ensuring the Survival of Hematopoietic Cells and Leukemia Cells in Mice.
The American journal of pathology Jun, 2018 | Pubmed ID: 29574182
Comparative analysis of the microstructures and mechanical properties of Co-Cr dental alloys fabricated by different methods.
The Journal of prosthetic dentistry Apr, 2018 | Pubmed ID: 29627206
Tocopherols inhibit esophageal carcinogenesis through attenuating NF-κB activation and CXCR3-mediated inflammation.
Oncogene Jul, 2018 | Pubmed ID: 29662196
Low warfarin resistance frequency in Norway rats in two cities in China after 30 years of usage of anticoagulant rodenticides.
Pest management science Apr, 2018 | Pubmed ID: 29667309
Efficacy and safety of electro-acupuncture treatment in improving the consciousness of patients with traumatic brain injury: study protocol for a randomized controlled trial.
Trials May, 2018 | Pubmed ID: 29843761
Kinship analysis reveals reproductive success skewed toward overwintered Brandt's voles in semi-natural enclosures.
Integrative zoology May, 2018 | Pubmed ID: 29851292
[Effects of intradermal needling combined with on ankle sprain sequelae].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Jun, 2018 | Pubmed ID: 29971999
Effect of Liuzijue Exercise Combined with Elastic Band Resistance Exercise on Patients with COPD: A Randomized Controlled Trial.
Evidence-based complementary and alternative medicine : eCAM , 2018 | Pubmed ID: 29991952
[Effects of acupuncture and moxibustion at different times on the nausea and vomiting induced with chemotherapy: a self cross control study].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion Jul, 2018 | Pubmed ID: 30014660
Development of in Planta Chemical Cross-Linking-Based Quantitative Interactomics in Arabidopsis.
Journal of proteome research 09, 2018 | Pubmed ID: 30084631
Effectiveness of high-intensity interval training on glycemic control and cardiorespiratory fitness in patients with type 2 diabetes: a systematic review and meta-analysis.
Aging clinical and experimental research May, 2019 | Pubmed ID: 30097811
Quantitative and functional posttranslational modification proteomics reveals that TREPH1 plays a role in plant touch-delayed bolting.
Proceedings of the National Academy of Sciences of the United States of America 10, 2018 | Pubmed ID: 30291188
Effects of home-based prescribed pulmonary exercise by patients with chronic obstructive pulmonary disease: study protocol for a randomized controlled trial.
Trials Jan, 2019 | Pubmed ID: 30635038
Characterization of product-related low molecular weight impurities in therapeutic monoclonal antibodies using hydrophilic interaction chromatography coupled with mass spectrometry.
Journal of pharmaceutical and biomedical analysis May, 2018 | Pubmed ID: 29587227
Ultrasensitive Characterization of Charge Heterogeneity of Therapeutic Monoclonal Antibodies Using Strong Cation Exchange Chromatography Coupled to Native Mass Spectrometry.
Analytical chemistry Nov, 2018 | Pubmed ID: 30280893
Simple Approach for Improved LC-MS Analysis of Protein Biopharmaceuticals via Modification of Desolvation Gas.
Analytical chemistry Feb, 2019 | Pubmed ID: 30682238
Coupling Mixed-Mode Size Exclusion Chromatography with Native Mass Spectrometry for Sensitive Detection and Quantitation of Homodimer Impurities in Bispecific IgG.
Analytical chemistry Sep, 2019 | Pubmed ID: 31373790
Quantitation and modeling of post-translational modifications in a therapeutic monoclonal antibody from single- and multiple-dose monkey pharmacokinetic studies using mass spectrometry.
PloS one , 2019 | Pubmed ID: 31618250
Improved Host Cell Protein Analysis in Monoclonal Antibody Products through Molecular Weight Cutoff Enrichment.
Analytical chemistry Mar, 2020 | Pubmed ID: 31999105
Online coupling of analytical hydrophobic interaction chromatography with native mass spectrometry for the characterization of monoclonal antibodies and related products.
Journal of pharmaceutical and biomedical analysis Jul, 2020 | Pubmed ID: 32371326
Combination of FAIMS, Protein A Depletion, and Native Digest Conditions Enables Deep Proteomic Profiling of Host Cell Proteins in Monoclonal Antibodies.
Analytical chemistry Aug, 2020 | Pubmed ID: 32628830
Characterization of Adeno-Associated Virus Capsid Proteins Using Hydrophilic Interaction Chromatography Coupled with Mass Spectrometry.
Journal of pharmaceutical and biomedical analysis Sep, 2020 | Pubmed ID: 32750536
Versatile, Sensitive, and Robust Native LC-MS Platform for Intact Mass Analysis of Protein Drugs.
Journal of the American Society for Mass Spectrometry Oct, 2020 | Pubmed ID: 32865416
Improved host cell protein analysis in monoclonal antibody products through ProteoMiner.
Analytical biochemistry Dec, 2020 | Pubmed ID: 32979367
Isotyping and Semi-Quantitation of Monkey Anti-Drug Antibodies by Immunocapture Liquid Chromatography-Mass Spectrometry.
The AAPS journal Jan, 2021 | Pubmed ID: 33404777
Electron Transfer Dissociation Parameter Optimization Using Design of Experiments Increases Sequence Coverage of Monoclonal Antibodies.
Journal of the American Society for Mass Spectrometry Mar, 2021 | Pubmed ID: 33596068
Integration of liquid chromatography mass spectrometry with a heavy peptide response curve accurately measures unprocessed C-terminal lysine during peptide mapping analysis of therapeutic antibodies in a single run.
Journal of pharmaceutical and biomedical analysis Apr, 2021 | Pubmed ID: 33626446
Simple and Sensitive Method for Deep Profiling of Host Cell Proteins in Therapeutic Antibodies by Combining Ultra-Low Trypsin Concentration Digestion, Long Chromatographic Gradients, and BoxCar Mass Spectrometry Acquisition.
Analytical chemistry Mar, 2021 | Pubmed ID: 33656852
Toward unbiased identification and comparative quantification of host cell protein impurities by automated iterative LC-MS/MS (HCP-AIMS) for therapeutic protein development.
Journal of pharmaceutical and biomedical analysis Jun, 2021 | Pubmed ID: 33901758
Analytical characterization of DNA and RNA oligonucleotides by hydrophilic interaction liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A Jul, 2021 | Pubmed ID: 33991753
Glycine additive enhances sensitivity for N- and O-glycan analysis with hydrophilic interaction chromatography-electrospray ionization-mass spectrometry.
Analytical biochemistry Dec, 2021 | Pubmed ID: 34742721
Metabolic analysis of the asparagine and glutamine dynamics in an industrial Chinese hamster ovary fed-batch process.
Biotechnology and bioengineering Mar, 2022 | Pubmed ID: 34786689
Post-Column Denaturation-Assisted Native Size-Exclusion Chromatography-Mass Spectrometry for Rapid and In-Depth Characterization of High Molecular Weight Variants in Therapeutic Monoclonal Antibodies.
Journal of the American Society for Mass Spectrometry Dec, 2021 | Pubmed ID: 34786946
Development of a simple non-reduced peptide mapping method that prevents disulfide scrambling of mAbs without affecting tryptic enzyme activity.
Journal of pharmaceutical and biomedical analysis Feb, 2022 | Pubmed ID: 34954467
Low pK of Lys promotes glycation at one complementarity-determining region of a bispecific antibody.
Biophysical journal Mar, 2022 | Pubmed ID: 35122736
Coupling Anion Exchange Chromatography with Native Mass Spectrometry for Charge Heterogeneity Characterization of Monoclonal Antibodies.
Analytical chemistry Apr, 2022 | Pubmed ID: 35420790
Activity-Based Protein Profiling Probe for the Detection of Enzymes Catalyzing Polysorbate Degradation.
Analytical chemistry Jun, 2022 | Pubmed ID: 35679579
High throughput and high confidence sequence variant analysis in therapeutic antibodies using Evosep One liquid chromatography tandem mass spectrometry with synthetic heavy peptides.
Journal of pharmaceutical and biomedical analysis Sep, 2022 | Pubmed ID: 35810724
The Characterization of Polysorbate.
Current protocols Jul, 2022 | Pubmed ID: 35857882
Analysis of Host Cell Proteins in Monoclonal Antibody Therapeutics Through Size Exclusion Chromatography.
Pharmaceutical research Nov, 2022 | Pubmed ID: 36071355
Ultrasensitive method for profiling host cell proteins by coupling limited digestion to ProteoMiner technology.
Analytical biochemistry Nov, 2022 | Pubmed ID: 36130653
Maximizing hydrophobic peptide recovery in proteomics and antibody development using a mass spectrometry compatible surfactant.
Analytical biochemistry Dec, 2022 | Pubmed ID: 36162445
Identification and Quantification of a Problematic Host Cell Protein to Support Therapeutic Protein Development.
Journal of pharmaceutical sciences Mar, 2023 | Pubmed ID: 36220394
A generic platform to couple affinity chromatography with native mass spectrometry for the analysis of therapeutic monoclonal antibodies.
Journal of pharmaceutical and biomedical analysis May, 2023 | Pubmed ID: 36933319
Dupilumab pharmacokinetics and effect on type 2 biomarkers in children with moderate-to-severe asthma.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Jul, 2023 | Pubmed ID: 36958470
Ultrasensitive Quantification Method for Understanding Biologically Relevant Concentrations of Host Cell Proteins in Therapeutics.
Analytical chemistry Apr, 2023 | Pubmed ID: 36977129
Understanding the structure-property relationship of bispecific monoclonal antibodies with Fc site-specific substitutions.
mAbs , 2023 | Pubmed ID: 37357447
Investigation of High Molecular Weight Size Variant Formation in Antibody-Drug Conjugates: Microbial Transglutaminase-Mediated Crosslinking.
Journal of pharmaceutical sciences Oct, 2023 | Pubmed ID: 37586591
Discovery and Characterization of an Acid-Labile Serine-Lysine Cross-Link in Antibody High-Molecular-Weight Species Using a Multipronged Mass Spectrometry Approach.
Analytical chemistry Sep, 2023 | Pubmed ID: 37674418
Xiaodan Liu1,2,
Peijun Li3,
Jian Li3,
Lu Xiao1,
Ning Li3,
Yufan Lu3,
Zhengrong Wang3,
Jianqing Su3,
Zhenwei Wang4,
Chunlei Shan1,2,
Weibing Wu3
1School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine,
2Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine,
3Department of Sports Medicine, Shanghai University of Sport,
4Department of Respiratory Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine