Tanz Centre for Research in Neurodegenerative Diseases
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Shear stress regulates forward and reverse planar cell polarity of vascular endothelium in vivo and in vitro.
Circulation research Apr, 2006 | Pubmed ID: 16527990
Force-induced polarized mitosis of endothelial and smooth muscle cells in arterial remodeling.
Hypertension (Dallas, Tex. : 1979) Jul, 2007 | Pubmed ID: 17485596
Homotypic and endothelial cell adhesions via N-cadherin determine polarity and regulate migration of vascular smooth muscle cells.
Circulation research Aug, 2008 | Pubmed ID: 18617695
Proteome alteration of U251 human astrocytoma cell after inhibiting retinoic acid synthesis.
Molecular and cellular biochemistry Mar, 2009 | Pubmed ID: 19089318
Role of tumour necrosis factor-alpha and other cytokines in ischemia-reperfusion-induced injury in the heart.
Experimental and clinical cardiology , 2005 | Pubmed ID: 19641672
Mechanotransduction by endothelial cells is locally generated, direction-dependent, and ligand-specific.
Journal of cellular physiology Aug, 2010 | Pubmed ID: 20432432
Rear polarization of the microtubule-organizing center in neointimal smooth muscle cells depends on PKCα, ARPC5, and RHAMM.
The American journal of pathology Feb, 2011 | Pubmed ID: 21281821
Cadherins at cell-autonomous membrane contacts control macropinocytosis.
Journal of cell science Jun, 2011 | Pubmed ID: 21610088
Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.
Molecular & cellular proteomics : MCP Nov, 2014 | Pubmed ID: 25044020
GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2014 | Pubmed ID: 25274827
The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients.
Acta neuropathologica May, 2015 | Pubmed ID: 25716178
Mutation analysis of CHCHD10 in different neurodegenerative diseases.
Brain : a journal of neurology Sep, 2015 | Pubmed ID: 25833818
Drug repositioning for diabetes based on 'omics' data mining.
PloS one , 2015 | Pubmed ID: 25946000
Characterization of Zinc Influx Transporters (ZIPs) in Pancreatic β Cells: ROLES IN REGULATING CYTOSOLIC ZINC HOMEOSTASIS AND INSULIN SECRETION.
The Journal of biological chemistry Jul, 2015 | Pubmed ID: 25969539
Jump from pre-mutation to pathologic expansion in C9orf72.
American journal of human genetics Jun, 2015 | Pubmed ID: 26004200
The Identification of Novel Protein-Protein Interactions in Liver that Affect Glucagon Receptor Activity.
PloS one , 2015 | Pubmed ID: 26075596
Mutation analysis of C9orf72 in patients with corticobasal syndrome.
Neurobiology of aging Oct, 2015 | Pubmed ID: 26166205
Isoform-specific antibodies reveal distinct subcellular localizations of C9orf72 in amyotrophic lateral sclerosis.
Annals of neurology Oct, 2015 | Pubmed ID: 26174152
A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells.
The Journal of biological chemistry Oct, 2015 | Pubmed ID: 26272612
Mutation analysis of CHCHD2 in Canadian patients with familial Parkinson's disease.
Neurobiology of aging Feb, 2016 | Pubmed ID: 26639156
Genetic and epigenetic study of ALS-discordant identical twins with double mutations in SOD1 and ARHGEF28.
Journal of neurology, neurosurgery, and psychiatry 11, 2016 | Pubmed ID: 27154192
A Predictive Metabolic Signature for the Transition From Gestational Diabetes Mellitus to Type 2 Diabetes.
Diabetes 09, 2016 | Pubmed ID: 27338739
Spinal column chordoma: prognostic significance of clinical variables and T (brachyury) gene SNP rs2305089 for local recurrence and overall survival.
Neuro-oncology 03, 2017 | Pubmed ID: 27663388
Marked Differences in C9orf72 Methylation Status and Isoform Expression between C9/ALS Human Embryonic and Induced Pluripotent Stem Cells.
Stem cell reports 11, 2016 | Pubmed ID: 27773700
Drug Repositioning for Alzheimer's Disease Based on Systematic 'omics' Data Mining.
PloS one , 2016 | Pubmed ID: 28005991
Genetic analysis of CHCHD2 and CHCHD10 in Italian patients with Parkinson's disease.
Neurobiology of aging 05, 2017 | Pubmed ID: 28108040
C9orf72 and ATXN2 repeat expansions coexist in a family with ataxia, dementia, and parkinsonism.
Movement disorders : official journal of the Movement Disorder Society Jan, 2017 | Pubmed ID: 28124431
DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients.
Acta neuropathologica Aug, 2017 | Pubmed ID: 28439722
The ONDRISeq panel: custom-designed next-generation sequencing of genes related to neurodegeneration.
NPJ genomic medicine , 2016 | Pubmed ID: 29263818
Unaffected mosaiccase: RNA foci, dipeptide proteins, but upregulated C9orf72 expression.
Neurology Jan, 2018 | Pubmed ID: 29282338
Mutation analysis of CHCHD2 and CHCHD10 in Italian patients with mitochondrial myopathy.
Neurobiology of aging Feb, 2018 | Pubmed ID: 29519717
Allison A. Dilliott1,2,
Sali M.K. Farhan3,
Mahdi Ghani4,
Christine Sato4,
Eric Liang5,
Ming Zhang4,
Adam D. McIntyre1,
Henian Cao1,
Lemuel Racacho6,7,
John F. Robinson1,
Michael J. Strong1,8,
Mario Masellis9,10,
Dennis E. Bulman6,7,
Ekaterina Rogaeva4,
Anthony Lang10,11,
Carmela Tartaglia4,10,
Elizabeth Finger12,13,
Lorne Zinman9,
John Turnbull14,
Morris Freedman10,15,
Rick Swartz9,
Sandra E. Black9,16,
Robert A. Hegele1,2
1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University,
2Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University,
3Analytic and Translational Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Massachusetts General Hospital, Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard,
4Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto,
5School of Medicine, Faculty of Health Sciences, Queen's University,
6Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa,
7CHEO Research Institute, Faculty of Medicine, University of Ottawa,
8Department of Clinical Neurological Sciences, Western University,
9Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto,
10Division of Neurology, Department of Medicine, University of Toronto,
11Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital,
12Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University,
13Parkwood Institute, St. Joseph's Health Care,
14Department of Medicine, Division of Neurology, McMaster University,
15Division of Neurology, Department of Medicine, Baycrest Health Sciences,
16Canadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Science Centre, University of Toronto
Smita Joshi*,1,
Alexis N. Smith1,
Kanakanagavalli Shravani Prakhya1,
Hammodah R. Alfar1,
Joshua Lykins1,
Ming Zhang1,
Irina Pokrovskaya2,
Maria Aronova3,
Richard D. Leapman3,
Brian Storrie2,
Sidney W. Whiteheart*,1
1Department of Molecular and Cellular Biochemistry, University of Kentucky,
2Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences,
3Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health