Sidney W. Whiteheart

How Does Protein Disulfide Isomerase Get Into a Thrombus?

Fueling Platelets: Where Does the Glucose Come From?

Dynamic cycling of t-SNARE acylation regulates platelet exocytosis.

The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells.

Uncoupling the ATPase activity of the N-ethylmaleimide sensitive factor (NSF) from 20S complex disassembly.

Application of a Saccharomyces cerevisiae model to study requirements for trafficking of Yersinia pestis YopM in eucaryotic cells.

Granule stores from cellubrevin/VAMP-3 null mouse platelets exhibit normal stimulus-induced release.

A role for Sec1/Munc18 proteins in platelet exocytosis.

Multiple binding proteins suggest diverse functions for the N-ethylmaleimide sensitive factor.

Studies of secretion using permeabilized platelets.

Platelets from Munc18c heterozygous mice exhibit normal stimulus-induced release.

Arf6 plays an early role in platelet activation by collagen and convulxin.

Endobrevin/VAMP-8 is the primary v-SNARE for the platelet release reaction.

Asymmetric accumulation of hippocampal 7S SNARE complexes occurs regardless of kindling paradigm.

Cellular functions of NSF: not just SNAPs and SNAREs.

Platelet activation and its patient-specific consequences.

Primary platelet signaling cascades and integrin-mediated signaling control ADP-ribosylation factor (Arf) 6-GTP levels during platelet activation and aggregation.

Murine platelets are not regulated by O-linked beta-N-acetylglucosamine.

Levetiracetam prevents kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes.

The platelet release reaction: just when you thought platelet secretion was simple.

PKCalpha regulates platelet granule secretion and thrombus formation in mice.

Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo.

Dissecting the N-ethylmaleimide-sensitive factor: required elements of the N and D1 domains.

Hexahistidine-tag-specific optical probes for analyses of proteins and their interactions.

Protein expression in platelets from six species that differ in their open canalicular system.

Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis.

Histidine-tag-directed chromophores for tracer analyses in the analytical ultracentrifuge.

A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing.

Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF).

Platelet granules: surprise packages.

Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling.

Kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes correlates with enhanced glutamate release.

Reduction of vesicle-associated membrane protein 2 expression leads to a kindling-resistant phenotype in a murine model of epilepsy.

Nucleotide-dependent conformational changes in the N-Ethylmaleimide Sensitive Factor (NSF) and their potential role in SNARE complex disassembly.

Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion.

Munc18b/STXBP2 is required for platelet secretion.

The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation.

Platelet secretion is kinetically heterogeneous in an agonist-responsive manner.

IκB kinase phosphorylation of SNAP-23 controls platelet secretion.

Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway.

α-Granules at the BEACH.

TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation.

Granule-mediated release of sphingosine-1-phosphate by activated platelets.

Platelet secretion and hemostasis require syntaxin-binding protein STXBP5.

Platelet secretion paves the way.

Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis.

Characterization of a Novel Integrin Binding Protein, VPS33B, Which Is Important for Platelet Activation and In Vivo Thrombosis and Hemostasis.

Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion.

Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking.

B-cell-independent sialylation of IgG.

Respective contributions of single and compound granule fusion to secretion by activated platelets.

The nuts and bolts of the platelet release reaction.

Editorial: Platelet Secretion.

The ins and outs of endocytic trafficking in platelet functions.

Cellubrevin/vesicle-associated membrane protein-3-mediated endocytosis and trafficking regulate platelet functions.

Linking kindling to increased glutamate release in the dentate gyrus of the hippocampus through the STXBP5/tomosyn-1 gene.

In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi.

BEACHcombing for α-granules.

Alterations in platelet secretion differentially affect thrombosis and hemostasis.

SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets.

Autophagy in Platelets.

Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics.

Canalicular system reorganization during mouse platelet activation as revealed by 3D ultrastructural analysis.

Platelets Endocytose Viral Particles and Are Activated via TLR (Toll-Like Receptor) Signaling.

Structural analysis of resting mouse platelets by 3D-EM reveals an unexpected variation in α-granule shape.

Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation.

Calcium Ion Chelation Preserves Platelet Function During Cold Storage.

Does GEC1 Enhance Expression and Forward Trafficking of the Kappa Opioid Receptor (KOR) via Its Ability to Interact with NSF Directly?

Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin.

Differential Leukocyte and Platelet Profiles in Distinct Models of Traumatic Brain Injury.

Platelet-HIV: interactions and their implications.

VAMP3 and VAMP8 Regulate the Development and Functionality of Parasitophorous Vacuoles Housing Leishmania amazonensis.

COMManding platelet α-granule cargo.

Total Plasma Protein S Is a Prothrombotic Marker in People Living With HIV.

A sensitive and adaptable method to measure platelet-fibrin clot contraction kinetics.

In memory of Dr. Susan S. Smyth, MD/Ph.D.