S'identifier

JoVE Journal

Neuroscience

This content is Open Access.

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System

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14:55 min

May 12th, 2013

May 12th, 2013

59,339 Views

0:05

Title

1:54

Pre-Surgical Procedure

3:49

Implantation of Alzet Osmotic Pump

8:01

Changing or Removing Alzet Osmotic Pump

9:51

Administration of an Intracerebroventricular Bolus

12:12

Results: Intraventricular Delivery of Antisense Oligonucleotides to the Rodent Central Nervous System

14:36

Conclusion

We describe a method to target drugs to the central nervous system by either implanting a catheter or performing a bolus injection into the right lateral ventricle in mice. We focus specifically on the delivery of antisense oligonucleotides. This technique is readily adaptable to other drugs and to rats.

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