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Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

13.3K Views

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10:13 min

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August 12th, 2014

DOI :

10.3791/51763-v

August 12th, 2014

•

13,335 Views

Robert S. McNeill¹, Ralf S. Schmid², Ryan E. Bash³, Mark Vitucci⁴, Kristen K. White¹, Andrea M. Werneke³, Brian H. Constance⁵, Byron Huff⁶, C. Ryan Miller²^,³^,⁷

¹Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, ²Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, ³Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, ⁴Curriculum in Genetics and Molecular Biology, University of North Carolina School of Medicine, ⁵Biological and Biomedical Sciences Program, University of North Carolina School of Medicine, ⁶Department of Radiation Oncology, Emory University School of Medicine, ⁷Department of Neurology, Neurosciences Center, University of North Carolina School of Medicine

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Résumé

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Cortical Astrocytes

Neural Stem Cells

Conditional Genetically Engineered Mice

Oncogenic Mutations

Tumor Suppressor Genes

In Vitro Transformation

Orthotopic Allografts

Bioluminescence Imaging

Preclinical Drug Development

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