Results: Glucose Resistance and Compensatory Hyperinsulinemia in Mice Fed a HFD
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Conclusion
Transcription
The overall goal of these procedures is to characterize the general metabolic phenotype of mice and to specifically assess alterations in glucose metabolism in vivo. These methods can help answer key questions in the field of metabolism. They are
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The current article describes the generation and metabolic characterization of high-fat diet-fed mice as a model of diet-induced insulin resistance and obesity. It further features detailed protocols to perform the oral glucose tolerance test and the insulin tolerance test, monitoring whole-body alterations of glucose metabolism in vivo.