Results: Dural Prolactin Stimulation in Mice as a Preclinical Headache Model
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Conclusion
Transcription
What events occur within the meninges that contribute to headache in the absence of tissue injury? Unlike prior use of dural stimulation models in rats, it allows the use of the extensive catalog of genetically modified mice. The primary struggle
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The most notable symptom of migraine is severe head pain, and it is hypothesized that this is mediated by sensory neurons innervating the meninges. Here, we present a method to locally apply substances to the dura in a minimally invasive manner while using facial hypersensitivity as an output.