Akiko Mammoto

Infiltration anesthetic lidocaine inhibits cancer cell invasion by modulating ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF).

Intravenous anesthetic, propofol inhibits invasion of cancer cells.

Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF.

Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition.

Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts.

The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.

Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo.

Rho signaling and mechanical control of vascular development.

ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells.

Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro.

Methods for studying mechanical control of angiogenesis by the cytoskeleton and extracellular matrix.

A mechanosensitive transcriptional mechanism that controls angiogenesis.

TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.

Discovery of potent and practical antiangiogenic agents inspired by cortistatin A.

Cytoskeletal control of growth and cell fate switching.

Paper-supported 3D cell culture for tissue-based bioassays.

Reconstituting organ-level lung functions on a chip.

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins.

Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion.

Multizone paper platform for 3D cell cultures.

Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation.

Wnt signaling mediates pathological vascular growth in proliferative retinopathy.

Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice.

Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning.

A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells.

Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix.

Mechanosensitive mechanisms in transcriptional regulation.

LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway.

Paxillin controls directional cell motility in response to physical cues.

Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein.

Control of lung vascular permeability and endotoxin-induced pulmonary oedema by changes in extracellular matrix mechanics.

Platelet rich plasma extract promotes angiogenesis through the angiopoietin1-Tie2 pathway.

Low urine vascular endothelial growth factor levels are associated with mechanical ventilation, bronchopulmonary dysplasia and retinopathy of prematurity.

Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan.

Extracellular matrix structure and tissue stiffness control postnatal lung development through the lipoprotein receptor-related protein 5/Tie2 signaling system.

GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2.

Epoxyeicosanoids promote organ and tissue regeneration.

Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression.

Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression.

Mechanobiology and developmental control.

Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression.

Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation.

Mechanotransduction of fluid stresses governs 3D cell migration.

Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro.

Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and demonstrates elevated expression in tumor tissue and urine of patients with pediatric medulloblastoma.

RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity.

Platelet-rich-plasma Extract Prevents Pulmonary Edema through Angiopoietin-Tie2 Signaling.

An extracorporeal blood-cleansing device for sepsis therapy.

Endothelial TWIST1 promotes pathological ocular angiogenesis.