Matthew S. Macauley

Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1.

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence.

O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis.

A highly concise preparation of O-deacetylated arylthioglycosides of N-acetyl-D-glucosamine from 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-glucopyranosyl chloride and aryl thiols or disulfides.

Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants.

Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity.

Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase.

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise.

Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation.

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.

Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance.

A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells.

Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases.

Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase.

Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase.

Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).

Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships.

Visualizing the reaction coordinate of an O-GlcNAc hydrolase.

Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes.

Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis.

Siglecs as sensors of self in innate and adaptive immune responses.

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of β-O-linked β-N-acetylglucosaminidase.

Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis.

Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.

Immunology: glyco-engineering 'super-self'.

Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas.

Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation.

Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing.

Siglec-mediated regulation of immune cell function in disease.

Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells.

Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases.

Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.

Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man.

Transfection of microRNA Mimics Should Be Used with Caution.

Targeting Selectins and Their Ligands in Cancer.

Reproducing SIVΔnef vaccine correlates of protection: trimeric gp41 antibody concentrated at mucosal front lines.

Siglec-F is a novel intestinal M cell marker.

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies.

Exploiting CD22 on antigen-specific B cells to prevent allergy to the major peanut allergen Ara h 2.

Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model.

Cell-based glycan arrays for probing glycan-glycan binding protein interactions.

Hypersialylation in Cancer: Modulation of Inflammation and Therapeutic Opportunities.