Department of Chemical Physiology
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Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1.
The Journal of biological chemistry Nov, 2004 | Pubmed ID: 15355965
O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.
The Journal of biological chemistry Jul, 2005 | Pubmed ID: 15795231
Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence.
The Journal of biological chemistry Feb, 2006 | Pubmed ID: 16319071
O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis.
Journal of the American Chemical Society Dec, 2005 | Pubmed ID: 16332065
A highly concise preparation of O-deacetylated arylthioglycosides of N-acetyl-D-glucosamine from 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-glucopyranosyl chloride and aryl thiols or disulfides.
Carbohydrate research Jul, 2006 | Pubmed ID: 16472788
Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants.
Biochemistry Mar, 2006 | Pubmed ID: 16533067
Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity.
Nature structural & molecular biology Apr, 2006 | Pubmed ID: 16565725
Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase.
The Biochemical journal Oct, 2006 | Pubmed ID: 16822234
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise.
Journal of the American Chemical Society Jan, 2007 | Pubmed ID: 17227027
Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation.
Nature structural & molecular biology Jul, 2008 | Pubmed ID: 18536723
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.
Nature chemical biology Aug, 2008 | Pubmed ID: 18587388
Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance.
The Journal of biological chemistry Dec, 2008 | Pubmed ID: 18842583
A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells.
Angewandte Chemie (International ed. in English) , 2009 | Pubmed ID: 19130519
Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases.
The Journal of biological chemistry Apr, 2009 | Pubmed ID: 19181667
Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase.
Carbohydrate research Jun, 2009 | Pubmed ID: 19423084
Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase.
Biochimica et biophysica acta Feb, 2010 | Pubmed ID: 19664691
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).
Proceedings of the National Academy of Sciences of the United States of America Aug, 2009 | Pubmed ID: 19666537
Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships.
Journal of the American Chemical Society Sep, 2009 | Pubmed ID: 19715310
Visualizing the reaction coordinate of an O-GlcNAc hydrolase.
Journal of the American Chemical Society Feb, 2010 | Pubmed ID: 20067256
Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes.
Chemistry & biology Sep, 2010 | Pubmed ID: 20851343
Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis.
Chemistry & biology Sep, 2010 | Pubmed ID: 20851344
Siglecs as sensors of self in innate and adaptive immune responses.
Annals of the New York Academy of Sciences Apr, 2012 | Pubmed ID: 22288608
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.
Nature chemical biology Apr, 2012 | Pubmed ID: 22366723
Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of β-O-linked β-N-acetylglucosaminidase.
The Journal of biological chemistry Aug, 2012 | Pubmed ID: 22692202
Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis.
The Journal of clinical investigation Jul, 2013 | Pubmed ID: 23722906
Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2013 | Pubmed ID: 23836061
Immunology: glyco-engineering 'super-self'.
Nature chemical biology Jan, 2014 | Pubmed ID: 24346034
Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas.
Chemical science (Royal Society of Chemistry : 2010) Jun, 2014 | Pubmed ID: 24921038
Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2014 | Pubmed ID: 25000981
Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing.
Nature immunology Oct, 2014 | Pubmed ID: 25173345
Siglec-mediated regulation of immune cell function in disease.
Nature reviews. Immunology Oct, 2014 | Pubmed ID: 25234143
Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2014 | Pubmed ID: 25252961
Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases.
The Journal of biological chemistry Dec, 2014 | Pubmed ID: 25368325
Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.
Trends in pharmacological sciences Oct, 2015 | Pubmed ID: 26435210
Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man.
The Journal of biological chemistry Dec, 2015 | Pubmed ID: 26507663
Transfection of microRNA Mimics Should Be Used with Caution.
Frontiers in genetics , 2015 | Pubmed ID: 26697058
Targeting Selectins and Their Ligands in Cancer.
Frontiers in oncology , 2016 | Pubmed ID: 27148485
Reproducing SIVΔnef vaccine correlates of protection: trimeric gp41 antibody concentrated at mucosal front lines.
AIDS (London, England) Jul, 2016 | Pubmed ID: 27428745
Siglec-F is a novel intestinal M cell marker.
Biochemical and biophysical research communications Oct, 2016 | Pubmed ID: 27524237
Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies.
Cell reports Aug, 2016 | Pubmed ID: 27545891
Exploiting CD22 on antigen-specific B cells to prevent allergy to the major peanut allergen Ara h 2.
The Journal of allergy and clinical immunology Aug, 2016 | Pubmed ID: 27554819
Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model.
Journal of immunology (Baltimore, Md. : 1950) 11, 2017 | Pubmed ID: 28972089
Cell-based glycan arrays for probing glycan-glycan binding protein interactions.
Nature communications 02, 2018 | Pubmed ID: 29491407
Hypersialylation in Cancer: Modulation of Inflammation and Therapeutic Opportunities.
Cancers Jun, 2018 | Pubmed ID: 29912148
Kyle J. Bednar*,1,
Lakeya Hardy*,2,3,
Johanna Smeekens*,3,4,
Dharmendra Raghuwanshi5,
Shiteng Duan6,
Mike D. Kulis3,4,
Matthew S. Macauley5,7
1, Janssen R&D,
2Department of Microbiology and Immunology, University of North Carolina,
3UNC Food Allergy Initiative, University of North Carolina,
4Department of Pediatrics, University of North Carolina,
5Department of Chemistry, University of Alberta,
6Department of Molecular Medicine, Scripps Research Institute,
7Department of Medical Microbiology and Immunology, University of Alberta
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