Edward W. Tate

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

A highly enantioselective total synthesis of (+)-goniodiol.

Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II.

Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins.

Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry.

N-myristoyltransferase: a prospective drug target for protozoan parasites.

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.

N-Myristoyl transferase-mediated protein labelling in vivo.

Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation.

Recent advances in chemical proteomics: exploring the post-translational proteome.

Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold.

Protein myristoylation in health and disease.

N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis.

Chemical probes of surface layer biogenesis in Clostridium difficile.

Getting a chemical handle on protein post-translational modification.

Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite.

Rapid multilabel detection of geranylgeranylated proteins by using bioorthogonal ligation chemistry.

Membrane enhanced peptide synthesis.

Comparing experimental and computational alanine scanning techniques for probing a prototypical protein-protein interaction.

Activity-based probes: discovering new biology and new drug targets.

Bioorthogonal chemical tagging of protein cholesterylation in living cells.

Activity-based profiling for drug discovery.

Roles of cysteine proteases Cwp84 and Cwp13 in biogenesis of the cell wall of Clostridium difficile.

Novel inhibitors of surface layer processing in Clostridium difficile.

Highlights from the 46th EUCHEM Conference on stereochemistry, Bürgenstock, Switzerland, May 2011.

A fluorescence-based assay for N-myristoyltransferase activity.

Application of activity-based protein profiling to the study of microbial pathogenesis.

Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry.

A new chemical handle for protein AMPylation at the host-pathogen interface.

Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.

Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.

A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei.

Regulation of the Plasmodium motor complex: phosphorylation of myosin A tail-interacting protein (MTIP) loosens its grip on MyoA.

Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.

Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase.

Automated fluorescence lifetime imaging plate reader and its application to Förster resonant energy transfer readout of Gag protein aggregation.

Chemical proteomics: a powerful tool for exploring protein lipidation.

N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis.

Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite.

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.

Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.

Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).

A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5.

Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation.

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors.

Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction.

Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites.

Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

Targeting a dynamic protein-protein interaction: fragment screening against the malaria myosin A motor complex.

Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.

Global profiling of protein lipidation using chemical proteomic technologies.

Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane protein.

Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity.

Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes.

New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish.

Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics.

Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines.

Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani.

The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain.

Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

Membrane bound O-acyltransferases and their inhibitors.

Cholesterylation: a tail of hedgehog.

Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors.

Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid.

Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor.

Myristoylation profiling in human cells and zebrafish.

Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.

Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase.

Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.

Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation.

Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach.

The Rab-binding Profiles of Bacterial Virulence Factors during Infection.

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase.

Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling.

Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase.

N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells.

Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei.

Direct Targeting of the Ras GTPase Superfamily Through Structure- Based Design.

Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells.

Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.

Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.