Chemical Biology Section,
Department of Chemistry,
Chemical Biology Section, Department of Chemistry
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Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.
The Biochemical journal Dec, 2007 | Pubmed ID: 17714074
A highly enantioselective total synthesis of (+)-goniodiol.
Organic & biomolecular chemistry May, 2006 | Pubmed ID: 16633562
Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II.
Chemical communications (Cambridge, England) Jul, 2006 | Pubmed ID: 17007393
Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins.
Chembiochem : a European journal of chemical biology Jul, 2007 | Pubmed ID: 17526063
Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry.
Chemical communications (Cambridge, England) Jan, 2008 | Pubmed ID: 18188474
N-myristoyltransferase: a prospective drug target for protozoan parasites.
ChemMedChem Mar, 2008 | Pubmed ID: 18324715
Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides.
Organic & biomolecular chemistry Apr, 2008 | Pubmed ID: 18385853
N-Myristoyl transferase-mediated protein labelling in vivo.
Organic & biomolecular chemistry Jul, 2008 | Pubmed ID: 18563263
Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation.
Chemical communications (Cambridge, England) Aug, 2008 | Pubmed ID: 18633492
Recent advances in chemical proteomics: exploring the post-translational proteome.
Journal of chemical biology Nov, 2008 | Pubmed ID: 19568795
Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold.
Journal of medicinal chemistry Oct, 2009 | Pubmed ID: 19772295
Protein myristoylation in health and disease.
Journal of chemical biology Nov, 2009 | Pubmed ID: 19898886
N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis.
Journal of molecular biology Mar, 2010 | Pubmed ID: 20036251
Chemical probes of surface layer biogenesis in Clostridium difficile.
ACS chemical biology Mar, 2010 | Pubmed ID: 20067320
Getting a chemical handle on protein post-translational modification.
Organic & biomolecular chemistry Feb, 2010 | Pubmed ID: 20135026
Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite.
Molecular bioSystems Mar, 2010 | Pubmed ID: 20174678
Rapid multilabel detection of geranylgeranylated proteins by using bioorthogonal ligation chemistry.
Chembiochem : a European journal of chemical biology Apr, 2010 | Pubmed ID: 20209562
Membrane enhanced peptide synthesis.
Chemical communications (Cambridge, England) Apr, 2010 | Pubmed ID: 20369190
Comparing experimental and computational alanine scanning techniques for probing a prototypical protein-protein interaction.
Protein engineering, design & selection : PEDS Jan, 2011 | Pubmed ID: 20656696
Activity-based probes: discovering new biology and new drug targets.
Chemical Society reviews Jan, 2011 | Pubmed ID: 20886146
Bioorthogonal chemical tagging of protein cholesterylation in living cells.
Chemical communications (Cambridge, England) Apr, 2011 | Pubmed ID: 21221452
Activity-based profiling for drug discovery.
Chemistry & biology Apr, 2011 | Pubmed ID: 21513874
Roles of cysteine proteases Cwp84 and Cwp13 in biogenesis of the cell wall of Clostridium difficile.
Journal of bacteriology Jul, 2011 | Pubmed ID: 21531808
Novel inhibitors of surface layer processing in Clostridium difficile.
Bioorganic & medicinal chemistry Jan, 2012 | Pubmed ID: 21752656
Highlights from the 46th EUCHEM Conference on stereochemistry, Bürgenstock, Switzerland, May 2011.
Chemical communications (Cambridge, England) Oct, 2011 | Pubmed ID: 21874182
A fluorescence-based assay for N-myristoyltransferase activity.
Analytical biochemistry Feb, 2012 | Pubmed ID: 22051857
Application of activity-based protein profiling to the study of microbial pathogenesis.
Topics in current chemistry , 2012 | Pubmed ID: 22102218
Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry.
Nature protocols Jan, 2012 | Pubmed ID: 22193303
A new chemical handle for protein AMPylation at the host-pathogen interface.
Chembiochem : a European journal of chemical biology Jan, 2012 | Pubmed ID: 22213418
Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.
Journal of medicinal chemistry Apr, 2012 | Pubmed ID: 22439843
Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.
PLoS neglected tropical diseases , 2012 | Pubmed ID: 22545171
A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei.
Biochimica et biophysica acta Jul, 2012 | Pubmed ID: 22609302
Regulation of the Plasmodium motor complex: phosphorylation of myosin A tail-interacting protein (MTIP) loosens its grip on MyoA.
The Journal of biological chemistry Oct, 2012 | Pubmed ID: 22932904
Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.
Journal of medicinal chemistry Oct, 2012 | Pubmed ID: 23035716
Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase.
Journal of medicinal chemistry Jan, 2013 | Pubmed ID: 23170970
Automated fluorescence lifetime imaging plate reader and its application to Förster resonant energy transfer readout of Gag protein aggregation.
Journal of biophotonics May, 2013 | Pubmed ID: 23184449
Chemical proteomics: a powerful tool for exploring protein lipidation.
Biochemical Society transactions Feb, 2013 | Pubmed ID: 23356258
N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis.
Parasitology Jan, 2014 | Pubmed ID: 23611109
Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite.
Biology open , 2013 | Pubmed ID: 24244852
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.
Nature chemistry Feb, 2014 | Pubmed ID: 24451586
Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.
PloS one , 2014 | Pubmed ID: 24608521
Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).
Journal of medicinal chemistry Mar, 2014 | Pubmed ID: 24641010
A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5.
Organic & biomolecular chemistry Jul, 2014 | Pubmed ID: 24848608
Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation.
Cell host & microbe Jul, 2014 | Pubmed ID: 25011111
Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors.
IUCrJ Jul, 2014 | Pubmed ID: 25075346
Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction.
ACS chemical biology Oct, 2014 | Pubmed ID: 25084543
Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites.
Organic & biomolecular chemistry Nov, 2014 | Pubmed ID: 25230674
Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.
Journal of medicinal chemistry Oct, 2014 | Pubmed ID: 25238611
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
Nature communications Sep, 2014 | Pubmed ID: 25255805
Targeting a dynamic protein-protein interaction: fragment screening against the malaria myosin A motor complex.
ChemMedChem Jan, 2015 | Pubmed ID: 25367834
Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions.
Structure (London, England : 1993) Dec, 2014 | Pubmed ID: 25435325
Global profiling of protein lipidation using chemical proteomic technologies.
Current opinion in chemical biology Feb, 2015 | Pubmed ID: 25461723
Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane protein.
The Journal of biological chemistry Feb, 2015 | Pubmed ID: 25505265
Synthesis of unsaturated phosphatidylinositol 4-phosphates and the effects of substrate unsaturation on SopB phosphatase activity.
Organic & biomolecular chemistry Feb, 2015 | Pubmed ID: 25515724
Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes.
PLoS neglected tropical diseases Dec, 2014 | Pubmed ID: 25522361
New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish.
Chemical science May, 2014 | Pubmed ID: 25574372
Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics.
Chemical communications (Cambridge, England) Mar, 2015 | Pubmed ID: 25598414
Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines.
The Journal of organic chemistry May, 2015 | Pubmed ID: 25713927
Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani.
Chemistry & biology Mar, 2015 | Pubmed ID: 25728269
The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain.
The Journal of biological chemistry May, 2015 | Pubmed ID: 25802338
Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.
Angewandte Chemie (International ed. in English) May, 2015 | Pubmed ID: 25807930
Membrane bound O-acyltransferases and their inhibitors.
Biochemical Society transactions Apr, 2015 | Pubmed ID: 25849925
Cholesterylation: a tail of hedgehog.
Biochemical Society transactions Apr, 2015 | Pubmed ID: 25849927
Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors.
Canadian journal of microbiology Sep, 2015 | Pubmed ID: 26059316
Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid.
Chemistry (Weinheim an der Bergstrasse, Germany) Jul, 2015 | Pubmed ID: 26079733
Legionella pneumophila Effector LpdA Is a Palmitoylated Phospholipase D Virulence Factor.
Infection and immunity Oct, 2015 | Pubmed ID: 26216420
Myristoylation profiling in human cells and zebrafish.
Data in brief Sep, 2015 | Pubmed ID: 26217820
Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics.
Chemistry & biology Aug, 2015 | Pubmed ID: 26256475
Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase.
Analytical biochemistry Dec, 2015 | Pubmed ID: 26334609
Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.
Advances in biological regulation Jan, 2016 | Pubmed ID: 26482290
Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation.
Chemistry & biology Nov, 2015 | Pubmed ID: 26584780
Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach.
Molecular & cellular proteomics : MCP Feb, 2016 | Pubmed ID: 26604261
The Rab-binding Profiles of Bacterial Virulence Factors during Infection.
The Journal of biological chemistry Mar, 2016 | Pubmed ID: 26755725
Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.
MedChemComm Oct, 2015 | Pubmed ID: 26962429
Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase.
MedChemComm Oct, 2015 | Pubmed ID: 26962430
Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling.
Molecular bioSystems May, 2016 | Pubmed ID: 27021930
Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase.
Data in brief Jun, 2016 | Pubmed ID: 27077078
N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells.
ACS chemical biology Aug, 2016 | Pubmed ID: 27267252
Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei.
ACS infectious diseases Jun, 2016 | Pubmed ID: 27331140
Direct Targeting of the Ras GTPase Superfamily Through Structure- Based Design.
Current topics in medicinal chemistry , 2017 | Pubmed ID: 27530972
Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells.
ACS chemical biology Dec, 2016 | Pubmed ID: 27779380
Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells.
ACS chemical biology Dec, 2016 | Pubmed ID: 27779865
Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.
Scientific reports Jan, 2017 | Pubmed ID: 28045057
Frederik Görlitz*,1,
Douglas J. Kelly*,1,
Sean C. Warren1,
Dominic Alibhai2,
Lucien West3,
Sunil Kumar1,
Yuriy Alexandrov1,
Ian Munro1,
Edwin Garcia1,
James McGinty1,
Clifford Talbot1,
Remigiusz A. Serwa4,
Emmanuelle Thinon4,
Vincenzo da Paola3,
Edward J. Murray5,
Frank Stuhmeier6,
Mark A. A. Neil1,
Edward W. Tate4,
Christopher Dunsby1,7,
Paul M. W. French1
1Photonics Group, Department of Physics, Imperial College London,
2Institute for Chemical Biology, Department of Chemistry, Imperial College London,
3MRC Clinical Sciences Centre, Hammersmith Hospital,
4Chemical Biology Section, Department of Chemistry, Imperial College London,
5, Retroscreen Virology Ltd,
6Pfizer Global Research and Development, Pfizer Limited, Sandwich, Kent, UK,
7Centre for Histopathology, Imperial College London
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