School of Life Sciences
Jonathan A. R. Worrall has not added Biography.
If you are Jonathan A. R. Worrall and would like to personalize this page please email our Author Liaison for assistance.
Cytochrome c6A: discovery, structure and properties responsible for its low haem redox potential.
Biochemical Society transactions Dec, 2008 | Pubmed ID: 19021519
Copper mining in Streptomyces: enzymes, natural products and development.
Natural product reports May, 2010 | Pubmed ID: 20372697
Thermodynamic analysis of Jun-Fos coiled coil peptide antagonists.
The FEBS journal Feb, 2011 | Pubmed ID: 21199371
Structural and kinetic studies of imidazole binding to two members of the cytochrome c (6) family reveal an important role for a conserved heme pocket residue.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry Apr, 2011 | Pubmed ID: 21267610
The role of a disulfide bridge in the stability and folding kinetics of Arabidopsis thaliana cytochrome c(6A).
Biochimica et biophysica acta Feb, 2012 | Pubmed ID: 22085909
An investigation into a cardiolipin acyl chain insertion site in cytochrome c.
Biochimica et biophysica acta May, 2012 | Pubmed ID: 22365930
Ferric haem forms of Mycobacterium tuberculosis catalase-peroxidase probed by EPR spectroscopy: Their stability and interplay with pH.
Biochimie Jun, 2012 | Pubmed ID: 22381358
Response to copper stress in Streptomyces lividans extends beyond genes under direct control of a copper-sensitive operon repressor protein (CsoR).
The Journal of biological chemistry May, 2012 | Pubmed ID: 22451651
Morphological development and cytochrome c oxidase activity in Streptomyces lividans are dependent on the action of a copper bound Sco protein.
Open biology Jan, 2013 | Pubmed ID: 23345541
The role of the Cys-X-X-X-Cys motif on the kinetics of cupric ion loading to the Streptomyces lividans Sco protein.
Dalton transactions (Cambridge, England : 2003) Aug, 2013 | Pubmed ID: 23759834
The hydrogen-peroxide-induced radical behaviour in human cytochrome c-phospholipid complexes: implications for the enhanced pro-apoptotic activity of the G41S mutant.
The Biochemical journal Dec, 2013 | Pubmed ID: 24099549
Conformational and thermodynamic hallmarks of DNA operator site specificity in the copper sensitive operon repressor from Streptomyces lividans.
Nucleic acids research Jan, 2014 | Pubmed ID: 24121681
Structural and mechanistic insights into an extracytoplasmic copper trafficking pathway in Streptomyces lividans.
The Biochemical journal May, 2014 | Pubmed ID: 24548299
Copper trafficking in the CsoR regulon of Streptomyces lividans.
Metallomics : integrated biometal science Jan, 2015 | Pubmed ID: 25409712
Backbone resonance assignments of ferric human cytochrome c and the pro-apoptotic G41S mutant in the ferric and ferrous states.
Biomolecular NMR assignments Oct, 2015 | Pubmed ID: 26123826
GlxA is a new structural member of the radical copper oxidase family and is required for glycan deposition at hyphal tips and morphogenesis of Streptomyces lividans.
The Biochemical journal Aug, 2015 | Pubmed ID: 26205496
Structural insights into conformational switching in the copper metalloregulator CsoR from Streptomyces lividans.
Acta crystallographica. Section D, Biological crystallography Sep, 2015 | Pubmed ID: 26327377
Copper and nickel bind via two distinct kinetic mechanisms to a CsoR metalloregulator.
Dalton transactions (Cambridge, England : 2003) Dec, 2015 | Pubmed ID: 26536457
The DyP-type peroxidase DtpA is a Tat-substrate required for GlxA maturation and morphogenesis in Streptomyces.
Open biology Jan, 2016 | Pubmed ID: 26740586
Heterogeneity in the Histidine-brace Copper Coordination Sphere in Auxiliary Activity Family 10 (AA10) Lytic Polysaccharide Monooxygenases.
The Journal of biological chemistry Jun, 2016 | Pubmed ID: 27129229
Increased dynamics in the 40-57 Ω-loop of the G41S variant of human cytochrome c promote its pro-apoptotic conformation.
Scientific reports Jul, 2016 | Pubmed ID: 27461282
Active-site maturation and activity of the copper-radical oxidase GlxA are governed by a tryptophan residue.
The Biochemical journal 02, 2017 | Pubmed ID: 28093470
Near-complete backbone resonance assignments of acid-denatured human cytochrome c in dimethylsulfoxide: a prelude to studying interactions with phospholipids.
Biomolecular NMR assignments Oct, 2017 | Pubmed ID: 28260216
Tyrosine or Tryptophan? Modifying a Metalloradical Catalytic Site by Removal of the Cys-Tyr Cross-Link in the Galactose 6-Oxidase Homologue GlxA.
Angewandte Chemie (International ed. in English) 06, 2017 | Pubmed ID: 28464409
Photoreduction and validation of haem-ligand intermediate states in protein crystals by single-crystal spectroscopy and diffraction.
IUCrJ May, 2017 | Pubmed ID: 28512573
Kinetic characterisation of a dye decolourising peroxidase from Streptomyces lividans: new insight into the mechanism of anthraquinone dye decolourisation.
Dalton transactions (Cambridge, England : 2003) Jul, 2017 | Pubmed ID: 28695933
Heightened Dynamics of the Oxidized Y48H Variant of Human Cytochrome c Increases Its Peroxidatic Activity.
Biochemistry 11, 2017 | Pubmed ID: 29083920
A cytosolic copper storage protein provides a second level of copper tolerance in Streptomyces lividans.
Metallomics : integrated biometal science 01, 2018 | Pubmed ID: 29292456
Naturally Occurring Disease-Related Mutations in the 40-57 Ω-Loop of Human Cytochrome c Control Triggering of the Alkaline Isomerization.
Biochemistry 07, 2018 | Pubmed ID: 29949346
An Aromatic Dyad Motif in Dye Decolourising Peroxidases Has Implications for Free Radical Formation and Catalysis.
Chemistry (Weinheim an der Bergstrasse, Germany) Apr, 2019 | Pubmed ID: 30945782
A Histidine Residue and a Tetranuclear Cuprous-thiolate Cluster Dominate the Copper Loading Landscape of a Copper Storage Protein from Streptomyces lividans.
Chemistry (Weinheim an der Bergstrasse, Germany) Aug, 2019 | Pubmed ID: 31111982
Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins.
IUCrJ Jul, 2019 | Pubmed ID: 31316799
High-throughput structures of protein-ligand complexes at room temperature using serial femtosecond crystallography.
IUCrJ Nov, 2019 | Pubmed ID: 31709063
Comparison of the structural dynamic and mitochondrial electron-transfer properties of the proapoptotic human cytochrome c variants, G41S, Y48H and A51V.
Journal of inorganic biochemistry 02, 2020 | Pubmed ID: 31760234
Successful sample preparation for serial crystallography experiments.
Journal of applied crystallography Dec, 2019 | Pubmed ID: 31798361
A subtle structural change in the distal haem pocket has a remarkable effect on tuning hydrogen peroxide reactivity in dye decolourising peroxidases from Streptomyces lividans.
Dalton transactions (Cambridge, England : 2003) Feb, 2020 | Pubmed ID: 31942590
Serial Femtosecond Zero Dose Crystallography Captures a Water-Free Distal Heme Site in a Dye-Decolorising Peroxidase to Reveal a Catalytic Role for an Arginine in Fe =O Formation.
Angewandte Chemie (International ed. in English) 11, 2020 | Pubmed ID: 32780931
Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis.
Structure (London, England : 1993) Jan, 2021 | Pubmed ID: 33444527
Iron oxidation in Escherichia coli bacterioferritin ferroxidase centre, a site designed to react rapidly with H2O2 but slowly with O2.
Angewandte Chemie (International ed. in English) Jan, 2021 | Pubmed ID: 33482043
Sam Horrell1,
Danny Axford1,
Nicholas E. Devenish1,
Ali Ebrahim1,
Michael A. Hough2,
Darren A. Sherrell1,3,
Selina L. S. Storm1,4,
Ivo Tews5,
Jonathan A. R. Worrall2,
Robin L. Owen1
1, Diamond Light Source, Harwell Science and Innovation Campus,
2School of Life Sciences, University of Essex,
3X-ray Science Division, Argonne National Laboratory,
4, European Molecular Biology Laboratory, Hamburg Outstation c/o DESY,
5Biological Sciences, Institute for Life Sciences, University of Southampton