Department of Neuropharmacology,
Interdisciplinary Graduate School of Medicine,
GLIA Center,
Faculty of Medicine,
Yamanashi GLIA center,
Department of Neuropharmacology, Faculty of Medicine,
Yamanashi GLIA center, Interdisciplinary Graduate School of Medicine,
Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine
Dr Koizumi received his PhD at Kyushu University majored in Neuropharmacology, and then did posdoc in Health Science foundation in Japan (Prof Inoue), and in Cambridge University in UK (Prof Mike Berridge). He got a Researcher position in 1999 in National Institute of Health Sciences in Japan, and then got a Professor position in 2007 at Faculty of Medicine, Univ Yamanashi in Japan.
Dr Koizumi is interested in physiology and pathophysiology of glia-neuron interaction in relation to several brain diseases. In 2021, He established Yamanashi GLIA Centre in the university, and is a director of the Centre. He is also interested in ATP purinertic signalling, a pivotal mediator between glia and neurons. The current special interest is to clarify mechanisms underlying synapse formation and elimination mediated by astrocytes/microglia in many of pathophysiological conditions.
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis.
Nature Apr, 2007 | Pubmed ID: 17410128
Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor.
Journal of neurochemistry Sep, 2007 | Pubmed ID: 17662046
The role of nucleotides in the neuron--glia communication responsible for the brain functions.
Journal of neurochemistry Sep, 2007 | Pubmed ID: 17697046
[Regulation of brain function mediated by glial ATP sensors].
Seikagaku. The Journal of Japanese Biochemical Society Jan, 2009 | Pubmed ID: 19260453
Grape seed extract acting on astrocytes reveals neuronal protection against oxidative stress via interleukin-6-mediated mechanisms.
Cellular and molecular neurobiology Dec, 2009 | Pubmed ID: 19381798
Direct observation of ATP-induced conformational changes in single P2X(4) receptors.
PLoS biology May, 2009 | Pubmed ID: 19419241
The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures.
The Journal of biological chemistry Aug, 2009 | Pubmed ID: 19531473
Synchronization of Ca2+ oscillations: involvement of ATP release in astrocytes.
The FEBS journal Jan, 2010 | Pubmed ID: 19895581
In vivo canine model comparison of cardiovascular effects of antidepressants milnacipran and imipramine.
Cardiovascular toxicology Dec, 2010 | Pubmed ID: 20680703
Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase.
The Journal of pharmacology and experimental therapeutics Oct, 2011 | Pubmed ID: 21765041
The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice.
PloS one , 2011 | Pubmed ID: 21876755
Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency.
The Journal of clinical investigation Feb, 2012 | Pubmed ID: 22214844
Cell-autonomous enhancement of glutamate-uptake by female astrocytes.
Cellular and molecular neurobiology Aug, 2012 | Pubmed ID: 22450870
Purinergic receptors in microglia: functional modal shifts of microglia mediated by P2 and P1 receptors.
Glia Jan, 2013 | Pubmed ID: 22674620
Purinergic signaling promotes proliferation of adult mouse subventricular zone cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2012 | Pubmed ID: 22764232
Secretion of matrix metalloproteinase-9 from astrocytes by inhibition of tonic P2Y14-receptor-mediated signal(s).
Cellular and molecular neurobiology Jan, 2013 | Pubmed ID: 22872320
In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties.
PloS one , 2013 | Pubmed ID: 23383092
Astrocytes protect neurons against methylmercury via ATP/P2Y(1) receptor-mediated pathways in astrocytes.
PloS one , 2013 | Pubmed ID: 23469098
Microglia release ATP by exocytosis.
Glia Aug, 2013 | Pubmed ID: 23832620
Involvement of glial P2Y₁ receptors in cognitive deficit after focal cerebral stroke in a rodent model.
Journal of neuroinflammation Jul, 2013 | Pubmed ID: 23890321
Mechanism underlying ATP release in human epidermal keratinocytes.
The Journal of investigative dermatology May, 2014 | Pubmed ID: 24292772
Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission.
Scientific reports Mar, 2014 | Pubmed ID: 24710318
Functional role for Piezo1 in stretch-evoked Ca²⁺ influx and ATP release in urothelial cell cultures.
The Journal of biological chemistry Jun, 2014 | Pubmed ID: 24759099
Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy.
Journal of neuropathology and experimental neurology Aug, 2014 | Pubmed ID: 25003238
TRPV4 regulates the integrity of the blood-cerebrospinal fluid barrier and modulates transepithelial protein transport.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jun, 2015 | Pubmed ID: 25681460
Long-term imipramine treatment increases N-methyl-d-aspartate receptor activity and expression via epigenetic mechanisms.
European journal of pharmacology Apr, 2015 | Pubmed ID: 25701723
Astrocyte-mediated ischemic tolerance.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2015 | Pubmed ID: 25740510
Müller cell-mediated neurite outgrowth of the retinal ganglion cells via P2Y receptor signals.
Journal of neurochemistry Feb, 2016 | Pubmed ID: 26560804
Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9.
Mechanisms of development 05, 2016 | Pubmed ID: 26940020
Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.
The Journal of clinical investigation May, 2016 | Pubmed ID: 27064281
The Clock mutant mouse is a novel experimental model for nocturia and nocturnal polyuria.
Neurourology and urodynamics Apr, 2017 | Pubmed ID: 27348079
Urothelial ATP exocytosis: regulation of bladder compliance in the urine storage phase.
Scientific reports 07, 2016 | Pubmed ID: 27412485
An effective therapeutic approach for oxaliplatin-induced peripheral neuropathy using a combination therapy with goshajinkigan and bushi.
Cancer biology & therapy 11, 2016 | Pubmed ID: 27416484
Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa.
PloS one , 2017 | Pubmed ID: 28060940
Hypoxia-independent mechanisms of HIF-1α expression in astrocytes after ischemic preconditioning.
Glia 03, 2017 | Pubmed ID: 28063215
Carbenoxolone inhibits TRPV4 channel-initiated oxidative urothelial injury and ameliorates cyclophosphamide-induced bladder dysfunction.
Journal of cellular and molecular medicine Feb, 2017 | Pubmed ID: 28244642
P2Y-deficiency increases micturition frequency and attenuates sustained contractility of the urinary bladder in mice.
Scientific reports 04, 2017 | Pubmed ID: 28396595
Pathologic Active mTOR Mutation in Brain Malformation with Intractable Epilepsy Leads to Cell-Autonomous Migration Delay.
The American journal of pathology May, 2017 | Pubmed ID: 28427592
Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y Receptor Downregulation.
Cell reports 05, 2017 | Pubmed ID: 28494865
Astrocyte-mediated synapse remodeling in the pathological brain.
Glia 11, 2017 | Pubmed ID: 28569048
Unconventional role of voltage-gated proton channels (VSOP/Hv1) in regulation of microglial ROS production.
Journal of neurochemistry 09, 2017 | Pubmed ID: 28628214
Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway.
Nature communications 06, 2017 | Pubmed ID: 28642575
Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation.
Scientific reports 07, 2017 | Pubmed ID: 28694451
The Circadian expression of Piezo1, TRPV4, Connexin26, and VNUT, associated with the expression levels of the clock genes in mouse primary cultured urothelial cells.
Neurourology and urodynamics 03, 2018 | Pubmed ID: 28881406
Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy.
JCI insight 10, 2017 | Pubmed ID: 28978804
Author Correction: Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway.
Nature communications 11, 2017 | Pubmed ID: 29138397
Astrocytes and ischemic tolerance.
Neuroscience research Jan, 2018 | Pubmed ID: 29225139
Astrocytes as therapeutic targets in brain diseases.
Neuroscience research 01, 2018 | Pubmed ID: 29289274
Role of Purinergic Receptor P2Y1 in Spatiotemporal Ca Dynamics in Astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 02, 2018 | Pubmed ID: 29305530
New roles of reactive astrocytes in the brain; an organizer of cerebral ischemia.
Neurochemistry international 10, 2018 | Pubmed ID: 29360494
Aberrant astrocyte Ca signals "AxCa signals" exacerbate pathological alterations in an Alexander disease model.
Glia 05, 2018 | Pubmed ID: 29383757
The oscillation of intracellular Ca influx associated with the circadian expression of Piezo1 and TRPV4 in the bladder urothelium.
Scientific reports 04, 2018 | Pubmed ID: 29632308
Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes.
EBioMedicine Jun, 2018 | Pubmed ID: 29887330
The time-dependent variation of ATP release in mouse primary-cultured urothelial cells is regulated by the clock gene.
Neurourology and urodynamics 11, 2018 | Pubmed ID: 30106187
Neuroprotective effects of microglial P2Y receptors against ischemic neuronal injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 11, 2019 | Pubmed ID: 30334687
Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium.
PloS one , 2018 | Pubmed ID: 30365528
Microglia mediate non-cell-autonomous cell death of retinal ganglion cells.
Glia 11, 2018 | Pubmed ID: 30375063
[Epileptogenesis mediated by glial cells].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica , 2018 | Pubmed ID: 30531096
Aberrant Calcium Signals in Reactive Astrocytes: A Key Process in Neurological Disorders.
International journal of molecular sciences Feb, 2019 | Pubmed ID: 30823575
Hyaluronan synthesis supports glutamate transporter activity.
Journal of neurochemistry 08, 2019 | Pubmed ID: 31188471
Evaluation of M1-microglial activation by neurotoxic metals using optimized organotypic cerebral slice cultures.
The Journal of toxicological sciences , 2019 | Pubmed ID: 31270303
Microglial ROCK is essential for chronic methylmercury-induced neurodegeneration.
Journal of neurochemistry 10, 2019 | Pubmed ID: 31278875
Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia.
Scientific reports 07, 2019 | Pubmed ID: 31296902
Snake venom rhodocytin induces plasma extravasation via toxin-mediated interactions between platelets and mast cells.
Scientific reports 11, 2019 | Pubmed ID: 31685912
Author Correction: Intermittent restraint stress induces circadian misalignment in the mouse bladder, leading to nocturia.
Scientific reports Nov, 2019 | Pubmed ID: 31700120
[Pathogenic roles of retinal glia in glaucoma].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica , 2020 | Pubmed ID: 32115484
Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation.
Journal of immunology (Baltimore, Md. : 1950) 06, 2020 | Pubmed ID: 32358018
Reactive astrocyte nomenclature, definitions, and future directions.
Nature neuroscience 03, 2021 | Pubmed ID: 33589835
Potential roles of astrocytes and Müller cells in the pathogenesis of glaucoma.
Journal of pharmacological sciences Mar, 2021 | Pubmed ID: 33602506
Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus.
JCI insight 05, 2021 | Pubmed ID: 33830944
Different effects of GsMTx4 on nocturia associated with the circadian clock and Piezo1 expression in mice.
Life sciences Aug, 2021 | Pubmed ID: 33930366
Mechanisms underlying sensitization of P2X7 receptors in astrocytes for induction of ischemic tolerance.
Glia 09, 2021 | Pubmed ID: 34076906
Mechanical stretch-induced ATP release from keratinocytes triggers Koebner phenomenon in psoriasis.
Journal of dermatological science Jul, 2021 | Pubmed ID: 34187740
Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis.
Science translational medicine 06, 2021 | Pubmed ID: 34193610
Loss of P2Y receptors triggers glaucoma-like pathology in mice.
British journal of pharmacology 11, 2021 | Pubmed ID: 34309010
Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice.
Glia 10, 2021 | Pubmed ID: 34309082
Adenosine A receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development.
Glia 11, 2021 | Pubmed ID: 34339538
Goshajinkigan attenuates paclitaxel-induced neuropathic pain via cortical astrocytes.
Pharmacology research & perspectives 12, 2021 | Pubmed ID: 34676996
Glial pharmacology in Asia & Beyond.
Pharmacology research & perspectives 12, 2021 | Pubmed ID: 34676997
Abnormal Ca Signals in Reactive Astrocytes as a Common Cause of Brain Diseases.
International journal of molecular sciences Dec, 2021 | Pubmed ID: 35008573
The Mlc1 Promoter Directs Müller Cell-specific Gene Expression in the Retina.
Translational vision science & technology 01, 2022 | Pubmed ID: 35040915
Glial Purinergic Signals and Psychiatric Disorders.
Frontiers in cellular neuroscience , 2021 | Pubmed ID: 35069121
Phagocytic astrocytes: Emerging from the shadows of microglia.
Glia Jun, 2022 | Pubmed ID: 35142399
Effects of fatty acid metabolites on nocturia.
Scientific reports 02, 2022 | Pubmed ID: 35197540
Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice.
The Journal of experimental medicine 04, 2022 | Pubmed ID: 35319723
P2X7 Receptors in Astrocytes: A Switch for Ischemic Tolerance.
Molecules (Basel, Switzerland) Jun, 2022 | Pubmed ID: 35744780
Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour.
Nature communications Jul, 2022 | Pubmed ID: 35835747
Ischemic Tolerance Induced by Glial Cells.
Neurochemical research Aug, 2022 | Pubmed ID: 35920970
1Department of Neurophysiology, Faculty of Medicine, University of Yamanashi,
2Department of Neuropharmacology, Faculty of Medicine, University of Yamanashi,
3Yamanashi GLIA center, Interdisciplinary Graduate School of Medicine, University of Yamanashi,
4Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo