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Division of Applied Regulatory Science,
Office of Clinical Pharmacology,
Office of Translational Sciences,
Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences
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Variability in Caco-2 and MDCK cell-based intestinal permeability assays.
Journal of pharmaceutical sciences Feb, 2008 | Pubmed ID: 17542022
Effect of ethanol on opioid drug permeability through caco-2 cell monolayers.
The AAPS journal Jun, 2008 | Pubmed ID: 18592381
Effect of altered temperature storage on the in vitro cellular uptake of liposome drug products.
Journal of liposome research Jun, 2010 | Pubmed ID: 19848447
Application of method suitability for drug permeability classification.
The AAPS journal Dec, 2010 | Pubmed ID: 20811966
Uniform assessment and ranking of opioid μ receptor binding constants for selected opioid drugs.
Regulatory toxicology and pharmacology : RTP Apr, 2011 | Pubmed ID: 21215785
Drug-permeability and transporter assays in Caco-2 and MDCK cell lines.
Future medicinal chemistry Dec, 2011 | Pubmed ID: 22098353
Effect of uremic serum and uremic toxins on drug metabolism in human microsomes.
Regulatory toxicology and pharmacology : RTP Mar, 2014 | Pubmed ID: 24184159
Use of different parameters and equations for calculation of IC₅₀ values in efflux assays: potential sources of variability in IC₅₀ determination.
The AAPS journal Jan, 2014 | Pubmed ID: 24338112
In vitro UGT1A1 inhibition by tyrosine kinase inhibitors and association with drug-induced hyperbilirubinemia.
Cancer chemotherapy and pharmacology 11, 2018 | Pubmed ID: 30105461
Methadone Metabolism and Drug-Drug Interactions: In Vitro and In Vivo Literature Review.
Journal of pharmaceutical sciences 12, 2018 | Pubmed ID: 30205091
Characterization of a commercially available line of iPSC hepatocytes as models of hepatocyte function and toxicity for regulatory purposes.
Journal of pharmacological and toxicological methods Jul-Aug, 2021 | Pubmed ID: 34098110
Center for Drug Evaluation and Research, Food and Drug Administration
Vojtech Gabriel1,
Christopher Zdyrski1,
Dipak K. Sahoo2,
Kimberly Dao3,
Agnes Bourgois-Mochel2,
Todd Atherly3,
Marilyn N. Martinez4,
Donna A. Volpe5,
Jamie Kopper2,
Karin Allenspach2,3,
Jonathan P. Mochel1,3
1Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University,
2Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University,
3, 3D Health Solutions Inc.,
4Office of New Animal Drug Evaluation, Center for Veterinary Medicine, Food and Drug Administration,
5Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Food and Drug Administration
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