Department of Traditional Chinese Medicine,
The Affiliated Hospital of Yangzhou University,
Department of Traditional Chinese and Western Medicine,
Medical College,
The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine,
Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases
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Study on the analgesic effect and mechanism of Zhitong capsule in adjuvant arthritis rats.
Chinese journal of integrative medicine Mar, 2005 | Pubmed ID: 15975308
[Experimental study on anti-tumor effect of extractive from Celastrus orbiculatus in vivo].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Sep, 2006 | Pubmed ID: 17144469
Celastrus orbiculatus extract inhibits tumor angiogenesis by targeting vascular endothelial growth factor signaling pathway and shows potent antitumor activity in hepatocarcinomas in Vitro and in Vivo.
Chinese journal of integrative medicine Oct, 2012 | Pubmed ID: 21805294
Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication.
Archives of virology Jun, 2012 | Pubmed ID: 22398914
Celastrol inhibits interleukin-17A-stimulated rheumatoid fibroblast-like synoviocyte migration and invasion through suppression of NF-κB-mediated matrix metalloproteinase-9 expression.
International immunopharmacology Dec, 2012 | Pubmed ID: 22954486
Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-κB/HIF-1α pathway.
Molecular immunology Mar, 2013 | Pubmed ID: 22960198
PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial-mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis.
Molecular and cellular biochemistry Jan, 2013 | Pubmed ID: 23001847
Celastrus orbiculatus extract induces mitochondrial-mediated apoptosis in human hepatocellular carcinoma cells.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Dec, 2012 | Pubmed ID: 23427399
Celastrol inhibits lipopolysaccharide-stimulated rheumatoid fibroblast-like synoviocyte invasion through suppression of TLR4/NF-κB-mediated matrix metalloproteinase-9 expression.
PloS one , 2013 | Pubmed ID: 23861949
Anti-invasive effects of celastrol in hypoxia-induced fibroblast-like synoviocyte through suppressing of HIF-1α/CXCR4 signaling pathway.
International immunopharmacology Dec, 2013 | Pubmed ID: 24144813
Anti-invasive effects of Celastrus Orbiculatus extract on interleukin-1 beta and tumour necrosis factor-alpha combination-stimulated fibroblast-like synoviocytes.
BMC complementary and alternative medicine Feb, 2014 | Pubmed ID: 24552146
Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κ B/Snail signaling pathway in human gastric adenocarcinoma.
BMC complementary and alternative medicine Nov, 2014 | Pubmed ID: 25370696
Extracts of Celastrus orbiculatus exhibit anti-proliferative and anti-invasive effects on human gastric adenocarcinoma cells.
Chinese journal of integrative medicine Nov, 2014 | Pubmed ID: 25382615
Antimetastatic effects of Celastrus orbiculatus on human gastric adenocarcinoma by inhibiting epithelial-mesenchymal transition and NF-κB/snail signaling pathway.
Integrative cancer therapies May, 2015 | Pubmed ID: 25722220
Chemotherapeutic Response and Prognosis among Lung Cancer Patients with and without Depression.
Journal of Cancer , 2015 | Pubmed ID: 26516360
Notch1 promotes vasculogenic mimicry in hepatocellular carcinoma by inducing EMT signaling.
Oncotarget Jan, 2017 | Pubmed ID: 27705934
Celastrus orbiculatus extract inhibits the migration and invasion of human glioblastoma cells in vitro.
BMC complementary and alternative medicine Oct, 2016 | Pubmed ID: 27716341
Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis.
Molecular medicine reports Nov, 2016 | Pubmed ID: 27748879
Vasculogenic mimicry in hepatocellular carcinoma contributes to portal vein invasion.
Oncotarget Nov, 2016 | Pubmed ID: 27793002
extract triggers apoptosis and autophagy via PI3K/Akt/mTOR inhibition in human colorectal cancer cells.
Oncology letters Nov, 2016 | Pubmed ID: 27895729
Anti-metastatic Efficacy of Traditional Chinese Medicine (TCM) Ginsenoside Conjugated to a VEFGR-3 Antibody on Human Gastric Cancer in an Orthotopic Mouse Model.
Anticancer research Mar, 2017 | Pubmed ID: 28314255
Cofilin 1 induces the epithelial-mesenchymal transition of gastric cancer cells by promoting cytoskeletal rearrangement.
Oncotarget Jun, 2017 | Pubmed ID: 28388575
Clinicopathological significance of ROCK1 and PIK3CA expression in nasopharyngeal carcinoma.
Experimental and therapeutic medicine Mar, 2017 | Pubmed ID: 28450943
Anticancer efficacy of the ethyl acetate extract from the traditional Chinese medicine herb Celastrus orbiculatus against human gastric cancer.
Journal of ethnopharmacology Jun, 2017 | Pubmed ID: 28476678
COE inhibits vasculogenic mimicry in hepatocellular carcinoma via suppressing Notch1 signaling.
Journal of ethnopharmacology Aug, 2017 | Pubmed ID: 28694103
extract suppresses the epithelial-mesenchymal transition by mediating cytoskeleton rearrangement via inhibition of the Cofilin 1 signaling pathway in human gastric cancer.
Oncology letters Sep, 2017 | Pubmed ID: 28927046
extracts induce apoptosis and inhibit invasion by targeting the maspin gene in human gastric adenocarcinoma cells.
Oncology letters Jan, 2018 | Pubmed ID: 29387218
extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells via the PI3K/AKT/mTOR signaling pathway.
Oncology letters Feb, 2018 | Pubmed ID: 29434854
Efficacy of extracts of in suppressing migration and invasion by inhibiting the EZH2/ROCK1 signaling pathway in human nasopharyngeal carcinoma.
Oncology letters May, 2018 | Pubmed ID: 29725411
Synthesis, in vitro cytotoxicity, and structure-activity relationships (SAR) of multidentate oxidovanadium(iv) complexes as anticancer agents.
Dalton transactions (Cambridge, England : 2003) Jul, 2018 | Pubmed ID: 29974097
Effects of Celastrus orbiculatus on Epithelial Mesenchymal Transition in Gastric Mucosal Epithelial Cells by Inhibiting Lgr5 Expression from Rats with Gastric Precancerous Lesions.
The American journal of Chinese medicine , 2018 | Pubmed ID: 29976080
Zusanli (ST36) Acupoint Injection with Neostigmine for Paralytic Postoperative Ileus following Radical Gastrectomy for Gastric Cancer: a Randomized Clinical Trial.
Journal of Cancer , 2018 | Pubmed ID: 30026821
Extracts of Celastrus Orbiculatus Inhibit Cancer Metastasis by Down-regulating Epithelial-Mesenchymal Transition in Hypoxia-Induced Human Hepatocellular Carcinoma Cells.
Chinese journal of integrative medicine May, 2019 | Pubmed ID: 30046956
[Effects of Osthole on Apoptosis of HL-60 Cells Induced by TRAIL and Its Related Mechanism].
Zhongguo shi yan xue ye xue za zhi Aug, 2018 | Pubmed ID: 30111400
Jinlong Capsule (JLC) inhibits proliferation and induces apoptosis in human gastric cancer cells in vivo and in vitro.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Nov, 2018 | Pubmed ID: 30138896
Traditional Chinese Medicine Integrated with Chemotherapy for Stage II-IIIA Patients with Non-Small-Cell Lung Cancer after Radical Surgery: A Retrospective Clinical Analysis with Small Sample Size.
Evidence-based complementary and alternative medicine : eCAM , 2018 | Pubmed ID: 30147731
Extract Potentiates the Sensitivity of Cisplatin Caspase-Depenent Apoptosis in Gastric Cancer.
Anti-cancer agents in medicinal chemistry , 2018 | Pubmed ID: 30205802
Polypharmacological Profiles Underlying the Antitumor Property of Root (Danshen) Interfering with NOX-Dependent Neutrophil Extracellular Traps.
Oxidative medicine and cellular longevity , 2018 | Pubmed ID: 30210653
Celastrus orbiculatus extracts induce apoptosis in mTOR-overexpressed human hepatocellular carcinoma HepG2 cells.
BMC complementary and alternative medicine Dec, 2018 | Pubmed ID: 30526568
Knockdown long noncoding RNA nuclear paraspeckle assembly transcript 1 suppresses colorectal cancer through modulating miR-193a-3p/KRAS.
Cancer medicine Jan, 2019 | Pubmed ID: 30575330
Transition metal substituted sandwich-type polyoxometalates with a strong metal-C (imidazole) bond as anticancer agents.
Chemical communications (Cambridge, England) Jan, 2019 | Pubmed ID: 30620027
SpyCLIP: an easy-to-use and high-throughput compatible CLIP platform for the characterization of protein-RNA interactions with high accuracy.
Nucleic acids research Apr, 2019 | Pubmed ID: 30715466
Effect of Celastrus orbiculatus in inhibiting Helicobacter pylori induced inflammatory response by regulating epithelial mesenchymal transition and targeting miR-21/PDCD4 signaling pathway in gastric epithelial cells.
BMC complementary and alternative medicine Apr, 2019 | Pubmed ID: 31035975
Celastrus orbiculatus Extracts Inhibit Human Hepatocellular Carcinoma Growth by Targeting mTOR Signaling Pathways.
Chinese journal of integrative medicine Nov, 2019 | Pubmed ID: 31127506
circFADS2 protects LPS-treated chondrocytes from apoptosis acting as an interceptor of miR-498/mTOR cross-talking.
Aging May, 2019 | Pubmed ID: 31141496
Cytotoxic abietane and kaurane diterpenoids from Celastrus orbiculatus.
Journal of natural medicines Sep, 2019 | Pubmed ID: 31197550
TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9.
Cell adhesion & migration Dec, 2019 | Pubmed ID: 31293204
Long non-coding RNA PVT1 knockdown suppresses fibroblast-like synoviocyte inflammation and induces apoptosis in rheumatoid arthritis through demethylation of .
Journal of biological engineering , 2019 | Pubmed ID: 31303891
Huachansu Capsule inhibits the proliferation of human gastric cancer cells via Akt/mTOR pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Oct, 2019 | Pubmed ID: 31351435
Extracts Inhibit the Metastasis through Attenuating PI3K/Akt/mTOR Signaling Pathway in Human Gastric Cancer.
Anti-cancer agents in medicinal chemistry , 2019 | Pubmed ID: 31364518
28-Hydroxy-3-oxoolean-12-en-29-oic Acid, a Triterpene Acid from Extract, Inhibits the Migration and Invasion of Human Gastric Cancer Cells In Vitro.
Molecules (Basel, Switzerland) Sep, 2019 | Pubmed ID: 31569766
Induction of APOBEC3C Facilitates the Genotoxic Stress-Mediated Cytotoxicity of Artesunate.
Chemical research in toxicology Dec, 2019 | Pubmed ID: 31664825
1,25-(OH)D/Vitamin D receptor alleviates systemic lupus erythematosus by downregulating Skp2 and upregulating p27.
Cell communication and signaling : CCS Dec, 2019 | Pubmed ID: 31823770
Corrigendum to "Huachansu capsule inhibits the proliferation of human gastric cancer cells via Akt/mTOR pathway" [Biomed. Pharmacother. 118 (2019) 109241].
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie Mar, 2020 | Pubmed ID: 31959384
CHIP-mediated ubiquitination of Galectin-1 predicts colorectal cancer prognosis.
International journal of biological sciences , 2020 | Pubmed ID: 32025218
Correction: Transition metal substituted sandwich-type polyoxometalates with a strong metal-C (imidazole) bond as anticancer agents.
Chemical communications (Cambridge, England) Feb, 2020 | Pubmed ID: 32031558
Synovial fibroblast-derived exosomal microRNA-106b suppresses chondrocyte proliferation and migration in rheumatoid arthritis via down-regulation of PDK4.
Journal of molecular medicine (Berlin, Germany) Mar, 2020 | Pubmed ID: 32152704
promotes metastasis and predicts prognosis in gastric cancer via regulating mTOR.
Biomarkers in medicine Apr, 2020 | Pubmed ID: 32175764
DJ‑1 promotes cell proliferation and tumor metastasis in esophageal squamous cell carcinoma via the Wnt/β‑catenin signaling pathway.
International journal of oncology May, 2020 | Pubmed ID: 32319588
DJ‑1 is a new prognostic marker and predicts chemotherapy efficacy in colorectal cancer.
Oncology reports Jul, 2020 | Pubmed ID: 32627002
A Study on the Effect and Mechanism of Xiaoaiping (XAP) Injection and S-1 Combination Therapy in Inhibiting the Invasion and Metastasis of Human GC Cells.
Anti-cancer agents in medicinal chemistry , 2021 | Pubmed ID: 32951585
Pristimerin synergizes with gemcitabine through abrogating Chk1/53BP1-mediated DNA repair in pancreatic cancer cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Jan, 2021 | Pubmed ID: 33301843
CD133+/CD166+ human gastric adenocarcinoma cells present the properties of neoplastic stem cells and emerge more malignant features.
Life sciences Mar, 2021 | Pubmed ID: 33450261
Vasculogenic mimicry, a negative indicator for progression free survival of lung adenocarcinoma irrespective of first line treatment and epithelial growth factor receptor mutation status.
BMC cancer Feb, 2021 | Pubmed ID: 33549061
Metabolomic Study on the Therapeutic Effect of the Jianpi Yangzheng Xiaozheng Decoction on Gastric Cancer Treated with Chemotherapy Based on GC-TOFMS Analysis.
Evidence-based complementary and alternative medicine : eCAM , 2021 | Pubmed ID: 33790982
COE Inhibits Vasculogenic Mimicry by Targeting EphA2 in Hepatocellular Carcinoma, a Research Based on Proteomics Analysis.
Frontiers in pharmacology , 2021 | Pubmed ID: 33867982
MicroRNA-21 from bone marrow mesenchymal stem cell-derived extracellular vesicles targets TET1 to suppress KLF4 and alleviate rheumatoid arthritis.
Therapeutic advances in chronic disease , 2021 | Pubmed ID: 33995992
Celastrol Inhibits the Proliferation and Decreases Drug Resistance of Cisplatin- Resistant Gastric Cancer SGC7901/DDP Cells.
Anti-cancer agents in medicinal chemistry , 2022 | Pubmed ID: 34053427
The Ethyl Acetate Extract From Promotes Apoptosis of Gastric Cancer Cells Through Mitochondria Regulation by PHB.
Frontiers in pharmacology , 2021 | Pubmed ID: 34122065
CXCR4 is a prognostic marker that inhibits the invasion and migration of gastric cancer by regulating VEGF expression.
Oncology letters Aug, 2021 | Pubmed ID: 34149898
Regulation of Cell Death Mechanisms by Melatonin: Implications in Cancer Therapy.
Anti-cancer agents in medicinal chemistry , 2022 | Pubmed ID: 34749627
A Comparison of Chemotherapy Used with and without Apatinib for Patients with Ovarian Carcinoma Who Progressed after Standard Regimens: A Systematic Review and Meta-Analysis.
Evidence-based complementary and alternative medicine : eCAM , 2021 | Pubmed ID: 34777533
Effect of Fuzheng Qingdu Therapy for Metastatic Gastric Cancer is Associated With Improved Survival: A Multicenter Propensity-Matched Study.
Integrative cancer therapies , 2021 | Pubmed ID: 34781754
Celastrus orbiculatus Extract Inhibits the Epithelial-Mesenchymal Transition Process by Transforming Growth Factor-β Signaling Pathway in Gastric Cancer.
Anti-cancer agents in medicinal chemistry , 2022 | Pubmed ID: 34895128
Altered expression levels of miR-144-3p and ATP1B2 are associated with schizophrenia.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry Nov, 2022 | Pubmed ID: 34989308
A long noncoding RNA, LncRNA-LOC100127888, is associated with poor prognosis in colorectal cancer patients.
Bulletin du cancer Mar, 2022 | Pubmed ID: 34991861
Exploring Anticancer Activities and Structure-Activity Relationships of Binuclear Oxidovanadium(IV) Complexes.
ACS applied bio materials Dec, 2021 | Pubmed ID: 35005923
Corrigendum: COE Inhibits Vasculogenic Mimicry by Targeting EphA2 in Hepatocellular Carcinoma, a Research Based on Proteomics Analysis.
Frontiers in pharmacology , 2021 | Pubmed ID: 35069227
[Corrigendum] DJ‑1 promotes cell proliferation and tumor metastasis in esophageal squamous cell carcinoma via the Wnt/β‑catenin signaling pathway.
International journal of oncology Mar, 2022 | Pubmed ID: 35147201
Betulonic Acid, as One of the Active Components of the Extract, Inhibits the Invasion and Metastasis of Gastric Cancer Cells by Mediating Cytoskeleton Rearrangement In Vitro.
Molecules (Basel, Switzerland) Feb, 2022 | Pubmed ID: 35164287
Corrigendum: The Ethyl Acetate Extract From Celastrus Orbiculatus Promotes Apoptosis of Gastric Cancer Cells Through Mitochondria Regulation by PHB.
Frontiers in pharmacology , 2022 | Pubmed ID: 35370664
Immortal Time Bias-Corrected Effectiveness of Traditional Chinese Medicine in Non-Small Cell Lung Cancer (C-EVID): A Prospective Cohort Study.
Frontiers in oncology , 2022 | Pubmed ID: 35530347
Metabolomics and molecular docking-directed antiarthritic study of the ethyl acetate extract from Celastrus orbiculatus Thunb.
Journal of ethnopharmacology Aug, 2022 | Pubmed ID: 35562091
Extract Inhibits the Invasion and Migration of Human Gastric Cancer Cells in the Hypoxia Microenvironment.
Anti-cancer agents in medicinal chemistry , 2022 | Pubmed ID: 35593351
Poria Acid, Triterpenoids Extracted from , Inhibits the Invasion and Metastasis of Gastric Cancer Cells.
Molecules (Basel, Switzerland) Jun, 2022 | Pubmed ID: 35684565
LncRNA-ENST00000543604 exerts a tumor-promoting effect miRNA 564/AEG-1 or ZNF326/EMT and predicts the prognosis of and chemotherapeutic effect in colorectal cancer.
Frontiers in oncology , 2022 | Pubmed ID: 36081570
Swollen inguinal lymph nodes with low fever and night sweat: diagnosis and treatment of case of cat-scratch disease lymphadenitis with sinus formation.
Heliyon Sep, 2022 | Pubmed ID: 36097471
UPLC-LTQ-Orbitrap-Based Cell Metabolomics and Network Pharmacology Analysis to Reveal the Potential Antiarthritic Effects of Pristimerin: In Vitro, In Silico and In Vivo Study.
Metabolites Sep, 2022 | Pubmed ID: 36144243
Celastrus orbiculatus Thunb. extract inhibits EMT and metastasis of gastric cancer by regulating actin cytoskeleton remodeling.
Journal of ethnopharmacology Jan, 2023 | Pubmed ID: 36179952
Effects of icariin on alleviating schizophrenia-like symptoms by regulating the miR-144-3p/ATP1B2/mTOR signalling pathway.
Neuroscience letters Nov, 2022 | Pubmed ID: 36261079
Rapid Screening of Proanthocyanidins from the Roots of Stapf and its Preventative Effects on Dextran-Sulfate-Sodium-Induced Ulcerative Colitis.
Metabolites Oct, 2022 | Pubmed ID: 36295859
Dysfunctional microRNA-144-3p/ZBTB20/ERK/CREB1 signalling pathway is associated with MK-801-induced schizophrenia-like abnormalities.
Brain research Jan, 2023 | Pubmed ID: 36335997
Triptonoterpene, a Natural Product from Thunb, Has Biological Activity against the Metastasis of Gastric Cancer Cells.
Molecules (Basel, Switzerland) Nov, 2022 | Pubmed ID: 36432106
Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3.
Biochemical pharmacology Feb, 2023 | Pubmed ID: 36493846
Network pharmacology-based analysis to explore the therapeutic mechanism of Cortex Dictamni on atopic dermatitis.
Journal of ethnopharmacology Mar, 2023 | Pubmed ID: 36535327
Dioscin induces M1 macrophage polarization through Connexin-43 Channels in Tumor-associated-macrophages-mediated melanoma metastasis.
Phytomedicine : international journal of phytotherapy and phytopharmacology Jan, 2023 | Pubmed ID: 36610151
PTBP1 drives c-Myc-dependent gastric cancer progression and stemness.
British journal of cancer Apr, 2023 | Pubmed ID: 36635500
The SIK1/CRTC2/CREB1 and TWIST1/PI3K/Akt/GSK3β signaling pathways mediated by microRNA-25-3p are altered in the schizophrenic rat brain.
Frontiers in cellular neuroscience , 2023 | Pubmed ID: 36744005
Betulinic acid, a major therapeutic triterpene of Celastrus orbiculatus Thunb., acts as a chemosensitizer of gemcitabine by promoting Chk1 degradation.
Journal of ethnopharmacology Jun, 2023 | Pubmed ID: 36813244
The anti-tumor effects of Celastrus orbiculatus Thunb. and its monomer composition: A review.
Journal of ethnopharmacology Mar, 2023 | Pubmed ID: 36948266
1Department of Traditional Chinese Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou University,
2Department of Traditional Chinese and Western Medicine, Medical College, Yangzhou University,
3The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Yangzhou University,
4Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University