Nabil G. Seidah

Biosynthesis and cellular trafficking of the convertase SKI-1/S1P: ectodomain shedding requires SKI-1 activity.

Proprotein convertases are important mediators of the adipocyte differentiation of mouse 3T3-L1 cells.

A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus.

Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy.

The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF).

Genetic mapping of the gene for SKI-1/S1P protease (locus symbol Mbtps1) to mouse chromosome 8.

Characterization of a repressor element in the promoter region of proprotein convertase 2 (PC2) gene.

Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study.

Structure-function analysis of the prosegment of the proprotein convertase PC5A.

Role of proprotein convertases in the pathogenic processing of the amyloidosis-associated form of secretory gelsolin.

Down-regulation of alpha v/beta 3 integrin via misrouting to lysosomes by overexpression of a beta 3Lamp1 fusion protein.

Precursor convertases in the secretory pathway, cytosol and extracellular milieu.

The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1.

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.

Proteolytic processing of chromogranin A by the prohormone convertase PC2.

Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo.

The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.

Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage.

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia.

A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.

The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.

Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1.

Neurotrophin-4, alone or heterodimerized with brain-derived neurotrophic factor, is sorted to the constitutive secretory pathway.

Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling.

Development of protein-based inhibitors of the proprotein of convertase SKI-1/S1P: processing of SREBP-2, ATF6, and a viral glycoprotein.

Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1.

Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model.

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.

Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase.

Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor.

Implications of proprotein Convertase 5 (PC5) in the arterial restenotic process in a porcine model.

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.

Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction.

The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.

Implication of proprotein convertases in the processing and spread of severe acute respiratory syndrome coronavirus.

Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.

Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells.

Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.

Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin.

Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.

Dual regulation of the LDL receptor--some clarity and new questions.

Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase.

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.

富含半胱氨酸的分泌的细菌性 convertases PC5A 和 PACE4 域函数作为细胞表面锚和金属蛋白酶抑制因子进行交互。

Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi.

Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse.

Unexpected similarity between the cytosolic West Nile virus NS3 and the secretory furin-like serine proteinases.

The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors.

Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system.

Increased stress-induced analgesia in mice lacking the proneuropeptide convertase PC2.

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.

The proprotein convertases and their implication in sterol and/or lipid metabolism.

Proprotein convertases: lessons from knockouts.

Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation.

Three common alleles of KIR2DL4 (CD158d) encode constitutively expressed, inducible and secreted receptors in NK cells.

The proprotein convertases are potential targets in the treatment of dyslipidemia.

The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR.

A targeted deletion/insertion in the mouse Pcsk1 locus is associated with homozygous embryo preimplantation lethality, mutant allele preferential transmission and heterozygous female susceptibility to dietary fat.

Of PCSK9, cholesterol homeostasis and parasitic infections: possible survival benefits of loss-of-function PCSK9 genetic polymorphisms.

The proprotein convertase SKI-1/S1P: alternate translation and subcellular localization.

PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism.

Plasma PCSK9 levels correlate with cholesterol in men but not in women.

Gene set enrichment analysis reveals several globally affected pathways due to SKI-1/S1P inhibition in HepG2 cells.

Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.

The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2.

Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases.

Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.

The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage : neurological Consequences of highly pathogenic Fujian H5N1 strains.

The activation and physiological functions of the proprotein convertases.

In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate.

PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans.

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5.

Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein.

Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration.

Potential role of proprotein convertase SKI-1 in the mineralization of primary bone.

Proprotein convertases as therapeutic targets.

Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low density lipoprotein receptor levels.

Emerging viruses: risk of pandemic.

PCSK9 as a therapeutic target of dyslipidemia.

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.

Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells.

PCSK9 impedes hepatitis C virus infection in vitro and modulates liver CD81 expression.

A new method for measurement of total plasma PCSK9: clinical applications.

Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route.

The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.

PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities.

Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels.

Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters.

Intestinal and hepatic cholesterol carriers in diabetic Psammomys obesus.

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo.

The influence of PCSK9 polymorphisms on serum low-density lipoprotein cholesterol and risk of atherosclerosis.

Zebrafish ProVEGF-C expression, proteolytic processing and inhibitory effect of unprocessed ProVEGF-C during fin regeneration.

Molecular cloning and embryonic expression of zebrafish PCSK5 co-orthologues: functional assessment during lateral line development.

Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events.

Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization.

The proprotein convertase PC7: unique zymogen activation and trafficking pathways.

Atorvastatin increases intestinal expression of NPC1L1 in hyperlipidemic men.

In vivo evidence that furin from hepatocytes inactivates PCSK9.

Surface expression of precursor N-cadherin promotes tumor cell invasion.

Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor.

Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue.

Quantitative proteomic analysis of PCSK9 gain of function in human hepatic HuH7 cells.

What lies ahead for the proprotein convertases?

PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke.

N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1.

Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.

Arenavirus envelope glycoproteins mimic autoprocessing sites of the cellular proprotein convertase subtilisin kexin isozyme-1/site-1 protease.

Inactivation of endothelial proprotein convertase 5/6 decreases collagen deposition in the cardiovascular system: role of fibroblast autophagy.

Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.

Effect of the Mediterranean diet with and without weight loss on surrogate markers of cholesterol homeostasis in men with the metabolic syndrome.

The proprotein convertases, 20 years later.

Novel loss-of-function PCSK9 variant is associated with low plasma LDL cholesterol in a French-Canadian family and with impaired processing and secretion in cell culture.

A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy.

The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography.

Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial.

Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice.

5-thiomannosides block the biosynthesis of dolichol-linked oligosaccharides and mimic class I congenital disorders of glycosylation.

SKI-1 and Furin generate multiple RGMa fragments that regulate axonal growth.

Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease.

Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.

SKI-1/S1P inhibition: a promising surrogate to statins to block hepatitis C virus replication.

The biology and therapeutic targeting of the proprotein convertases.

Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia.

Loss of endothelial furin leads to cardiac malformation and early postnatal death.

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation.

Loss- and Gain-of-function PCSK9 Variants: CLEAVAGE SPECIFICITY, DOMINANT NEGATIVE EFFECTS, AND LOW DENSITY LIPOPROTEIN RECEPTOR (LDLR) DEGRADATION.

Aortic calcification: Novel insights from familial hypercholesterolemia and potential role for the low-density lipoprotein receptor.

Opposite Roles of Furin and PC5A in N-Cadherin Processing.

The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 is needed for the extracellular low density lipoprotein receptor (LDLR) degradation pathway.

Automated design of ligands to polypharmacological profiles.

Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver.

Rapid development of sensitive, high-throughput, quantitative and highly selective mass spectrometric targeted immunoassays for clinically important proteins in human plasma and serum.

Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors in the treatment of hypercholesterolemia and other pathologies.

The cytosolic adaptor AP-1A is essential for the trafficking and function of Niemann-Pick type C proteins.

Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin.

PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells.

Correspondence.

Differential recognition of Old World and New World arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P).

Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels.

Viral envelope glycoprotein processing by proprotein convertases.

Beyond LDL-C lowering: distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1).

Regional distribution and metabolic effect of PCSK9 insLEU and R46L gene mutations and apoE genotype.

The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.

Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.

PCSK9 prosegment chimera as novel inhibitors of LDLR degradation.

Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model.

Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.

Processing of Human Toll-like Receptor 7 by Furin-like Proprotein Convertases Is Required for Its Accumulation and Activity in Endosomes.