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Heather Whetstone

Sickkids Research Institute

The Hospital for Sick Children

BIOGRAPHY

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PUBLICATIONS

Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology Apr, 2006 | Pubmed ID: 16581977

PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms.

Developmental biology May, 2007 | Pubmed ID: 17328886

Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing.

PLoS medicine Jul, 2007 | Pubmed ID: 17676991

T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair.

PloS one , 2012 | Pubmed ID: 22768215

β-Catenin-regulated myeloid cell adhesion and migration determine wound healing.

The Journal of clinical investigation Jun, 2014 | Pubmed ID: 24837430

Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia.

American journal of human genetics Dec, 2015 | Pubmed ID: 26637977

Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis.

The Journal of clinical investigation May, 2016 | Pubmed ID: 27018594

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.

Cancer cell Jun, 2016 | Pubmed ID: 27300435

Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype.

Cell reports Jul, 2016 | Pubmed ID: 27425618

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells.

Cell stem cell Aug, 2017 | Pubmed ID: 28712938

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy.

Nature Sep, 2017 | Pubmed ID: 28854171

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression.

Neuron Nov, 2018 | Pubmed ID: 30344046

Aged hind-limb clasping experimental autoimmune encephalomyelitis models aspects of the neurodegenerative process seen in multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America Nov, 2019 | Pubmed ID: 31641069

Medulloblastoma Arises from the Persistence of a Rare and Transient Sox2 Granule Neuron Precursor.

Cell reports Apr, 2020 | Pubmed ID: 32294450

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival.

eLife Jan, 2021 | Pubmed ID: 33427645

PRMT5 inhibition disrupts splicing and stemness in glioblastoma.

Nature communications 02, 2021 | Pubmed ID: 33579912

Peroxisome Proliferator-Activated Receptor-δ Deficiency in Microglia Results in Exacerbated Axonal Injury and Tissue Loss in Experimental Autoimmune Encephalomyelitis.

Frontiers in immunology , 2021 | Pubmed ID: 33732230

Modulation of Neutrophil Function by Recombinant Human IgG1 Fc Hexamer in the Endogenous K/BxN Mouse Model of Rheumatoid Arthritis.

Pharmacology , 2023 | Pubmed ID: 36696888

INSTITUTIONS

The Hospital for Sick Children

JOVE ARTICLES

Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis

Carmen C. Ucciferri¹,

Annette Gower²,

Nuria Alvarez-Sanchez^1,2,

Heather Whetstone³,

Valeria Ramaglia¹,

Jennifer L. Gommerman¹,

Koroboshka Brand-Arzamendi²,

Raphael Schneider^2,4,

Shannon E Dunn^1,2,5

¹Department of Immunology, University of Toronto,

², Keenan Research Centre for Biomedical Science of St. Michael’s Hospital,

³Sickkids Research Institute, The Hospital for Sick Children,

⁴BARLO MS Centre, St. Michael’s Hospital,

⁵Women’s College Research Institute, Women’s College Hospital

Immunology and Infection

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Heather Whetstone

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The Hospital for Sick Children

Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis

Sickkids Research Institute