Environmental Microfluidics Group
After a Ph.D. at the University of Padova and 13 years as an Instructor, Assistant Professor and Associate Professor at MIT, Roman Stocker became Professor of Groundwater and Hydromechanics and Group Leader of the Environmental Microfluidics Lab at ETH Zurich in 2015.
His research leverages microfluidics, state-of-the-art microscopy, image analysis, and mathematical modeling to understand how the lives of aquatic microbes, and ultimately their contribution to biogeochemical cycles at the ecosystem scale, are governed by fluid flow, motility and chemotaxis at the microscale.
Rapid chemotactic response enables marine bacteria to exploit ephemeral microscale nutrient patches.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2008 | Pubmed ID: 18337491
Experimental verification of the behavioral foundation of bacterial transport parameters using microfluidics.
Biophysical journal Nov, 2008 | Pubmed ID: 18658218
Disruption of vertical motility by shear triggers formation of thin phytoplankton layers.
Science (New York, N.Y.) Feb, 2009 | Pubmed ID: 19229037
Separation of microscale chiral objects by shear flow.
Physical review letters Apr, 2009 | Pubmed ID: 19522552
Microbiology. Tumbling for stealth?
Science (New York, N.Y.) Jul, 2009 | Pubmed ID: 19628846
Chemoattraction to dimethylsulfoniopropionate throughout the marine microbial food web.
Science (New York, N.Y.) Jul, 2010 | Pubmed ID: 20647471
Bacterial chemotaxis in linear and nonlinear steady microfluidic gradients.
Nano letters Sep, 2010 | Pubmed ID: 20669946
Filtration of submicrometer particles by pelagic tunicates.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2010 | Pubmed ID: 20696887
Microfluidics for bacterial chemotaxis.
Integrative biology : quantitative biosciences from nano to macro Nov, 2010 | Pubmed ID: 20967322
How cats lap: water uptake by Felis catus.
Science (New York, N.Y.) Nov, 2010 | Pubmed ID: 21071630
Diffusion-limited retention of porous particles at density interfaces.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2010 | Pubmed ID: 21135242
Reverse and flick: Hybrid locomotion in bacteria.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2011 | Pubmed ID: 21289282
Microbial alignment in flow changes ocean light climate.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2011 | Pubmed ID: 21368125
The ciliate Paramecium shows higher motility in non-uniform chemical landscapes.
PloS one , 2011 | Pubmed ID: 21494596
On the water lapping of felines and the water running of lizards: A unifying physical perspective.
Communicative & integrative biology Mar, 2011 | Pubmed ID: 21655444
Gyrotaxis in a steady vortical flow.
Physical review letters Jun, 2011 | Pubmed ID: 21770545
Response rescaling in bacterial chemotaxis.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2011 | Pubmed ID: 21808031
Systematic spatial bias in DNA microarray hybridization is caused by probe spot position-dependent variability in lateral diffusion.
PloS one , 2011 | Pubmed ID: 21858215
Microfluidic characterization and continuous separation of cells and particles using conducting poly(dimethyl siloxane) electrode induced alternating current-dielectrophoresis.
Analytical chemistry Dec, 2011 | Pubmed ID: 22035423
Low-Reynolds-number swimming at pycnoclines.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2012 | Pubmed ID: 22355147
Bacterial rheotaxis.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2012 | Pubmed ID: 22411815
Thin phytoplankton layers: characteristics, mechanisms, and consequences.
Annual review of marine science , 2012 | Pubmed ID: 22457973
Marine microbes see a sea of gradients.
Science (New York, N.Y.) Nov, 2012 | Pubmed ID: 23118182
Trade-offs of chemotactic foraging in turbulent water.
Science (New York, N.Y.) Nov, 2012 | Pubmed ID: 23118190
Ecology and physics of bacterial chemotaxis in the ocean.
Microbiology and molecular biology reviews : MMBR Dec, 2012 | Pubmed ID: 23204367
Turbulence drives microscale patches of motile phytoplankton.
Nature communications , 2013 | Pubmed ID: 23852011
The extracellular matrix Component Psl provides fast-acting antibiotic defense in Pseudomonas aeruginosa biofilms.
PLoS pathogens , 2013 | Pubmed ID: 23950711
Capillary interception of floating particles by surface-piercing vegetation.
Physical review letters Oct, 2013 | Pubmed ID: 24182270
A bacterial pathogen uses dimethylsulfoniopropionate as a cue to target heat-stressed corals.
The ISME journal May, 2014 | Pubmed ID: 24335830
Synergistic prevention of biofouling in seawater desalination by zwitterionic surfaces and low-level chlorination.
Advanced materials (Deerfield Beach, Fla.) Mar, 2014 | Pubmed ID: 24375685
Variability in microbial community composition and function between different niches within a coral reef.
Microbial ecology Apr, 2014 | Pubmed ID: 24477921
Turbulent fluid acceleration generates clusters of gyrotactic microorganisms.
Physical review letters Jan, 2014 | Pubmed ID: 24580457
Competition-dispersal tradeoff ecologically differentiates recently speciated marine bacterioplankton populations.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2014 | Pubmed ID: 24706766
Single-cell genomics reveals hundreds of coexisting subpopulations in wild Prochlorococcus.
Science (New York, N.Y.) Apr, 2014 | Pubmed ID: 24763590
Microfluidics expanding the frontiers of microbial ecology.
Annual review of biophysics , 2014 | Pubmed ID: 24773019
RecA protein plays a role in the chemotactic response and chemoreceptor clustering of Salmonella enterica.
PloS one , 2014 | Pubmed ID: 25147953
Failed escape: solid surfaces prevent tumbling of Escherichia coli.
Physical review letters Aug, 2014 | Pubmed ID: 25148353
Vortical ciliary flows actively enhance mass transport in reef corals.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2014 | Pubmed ID: 25192936
Chemotaxis by natural populations of coral reef bacteria.
The ISME journal Jan, 2015 | Pubmed ID: 25615440
Microbes in flow.
Current opinion in microbiology Mar, 2015 | Pubmed ID: 25812434
Sensitivity of the rate of nutrient uptake by chemotactic bacteria to physical and biological parameters in a turbulent environment.
Journal of theoretical biology Dec, 2015 | Pubmed ID: 26392215
Shear-induced orientational dynamics and spatial heterogeneity in suspensions of motile phytoplankton.
Journal of the Royal Society, Interface 11, 2015 | Pubmed ID: 26538558
Live from under the lens: exploring microbial motility with dynamic imaging and microfluidics.
Nature reviews. Microbiology Dec, 2015 | Pubmed ID: 26568072
Temperature-induced behavioral switches in a bacterial coral pathogen.
The ISME journal 06, 2016 | Pubmed ID: 26636553
Physical limits on bacterial navigation in dynamic environments.
Journal of the Royal Society, Interface Jan, 2016 | Pubmed ID: 26763331
Chemotaxis toward phytoplankton drives organic matter partitioning among marine bacteria.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2016 | Pubmed ID: 26802122
That sinking feeling: Suspended sediments can prevent the ascent of coral egg bundles.
Scientific reports Feb, 2016 | Pubmed ID: 26898352
A coral-on-a-chip microfluidic platform enabling live-imaging microscopy of reef-building corals.
Nature communications Mar, 2016 | Pubmed ID: 26940983
Sperm chemotaxis promotes individual fertilization success in sea urchins.
The Journal of experimental biology 05, 2016 | Pubmed ID: 26994183
Microfluidic Studies of Biofilm Formation in Dynamic Environments.
Journal of bacteriology 10, 2016 | Pubmed ID: 27274032
Intermittent turbulence in flowing bacterial suspensions.
Journal of the Royal Society, Interface 06, 2016 | Pubmed ID: 27307513
Speed-dependent chemotactic precision in marine bacteria.
Proceedings of the National Academy of Sciences of the United States of America 08, 2016 | Pubmed ID: 27439872
Natural search algorithms as a bridge between organisms, evolution, and ecology.
Proceedings of the National Academy of Sciences of the United States of America 08, 2016 | Pubmed ID: 27496324
The Microbial Olympics 2016.
Nature microbiology 07, 2016 | Pubmed ID: 27573121
Resilience of bacterial quorum sensing against fluid flow.
Scientific reports 09, 2016 | Pubmed ID: 27650454
Validation of picogram- and femtogram-input DNA libraries for microscale metagenomics.
PeerJ , 2016 | Pubmed ID: 27688978
A particularly useful system to study the ecology of microbes.
Environmental microbiology reports 02, 2017 | Pubmed ID: 27759951
Phytoplankton can actively diversify their migration strategy in response to turbulent cues.
Nature 03, 2017 | Pubmed ID: 28297706
Deployable micro-traps to sequester motile bacteria.
Scientific reports 04, 2017 | Pubmed ID: 28378786
Dual function of tropodithietic acid as antibiotic and signaling molecule in global gene regulation of the probiotic bacterium Phaeobacter inhibens.
Scientific reports 04, 2017 | Pubmed ID: 28389641
High-avidity IgA protects the intestine by enchaining growing bacteria.
Nature 04, 2017 | Pubmed ID: 28405025
Zooming in on the phycosphere: the ecological interface for phytoplankton-bacteria relationships.
Nature microbiology May, 2017 | Pubmed ID: 28555622
Biofilm disruption by an air bubble reveals heterogeneous age-dependent detachment patterns dictated by initial extracellular matrix distribution.
NPJ biofilms and microbiomes , 2017 | Pubmed ID: 28649407
Logarithmic sensing in aerotaxis.
NPJ systems biology and applications , 2017 | Pubmed ID: 28725484
A microfluidics-based in situ chemotaxis assay to study the behaviour of aquatic microbial communities.
Nature microbiology Oct, 2017 | Pubmed ID: 28848238
Redefining the sponge-symbiont acquisition paradigm: sponge microbes exhibit chemotaxis towards host-derived compounds.
Environmental microbiology reports Dec, 2017 | Pubmed ID: 28892304
Heterologous Expression of Pseudomonas putida Methyl-Accepting Chemotaxis Proteins Yields Escherichia coli Cells Chemotactic to Aromatic Compounds.
Applied and environmental microbiology 09, 2018 | Pubmed ID: 30006400
Synthesis and degradation of FtsZ quantitatively predict the first cell division in starved bacteria.
Molecular systems biology 11, 2018 | Pubmed ID: 30397005
A Foraging Mandala for Aquatic Microorganisms.
The ISME journal 03, 2019 | Pubmed ID: 30446738
An automated Raman-based platform for the sorting of live cells by functional properties.
Nature microbiology 06, 2019 | Pubmed ID: 30886359
The role of microbial motility and chemotaxis in symbiosis.
Nature reviews. Microbiology 05, 2019 | Pubmed ID: 30923350
Publisher Correction: An automated Raman-based platform for the sorting of live cells by functional properties.
Nature microbiology May, 2019 | Pubmed ID: 30980037
Bacterial chemotaxis in a microfluidic T-maze reveals strong phenotypic heterogeneity in chemotactic sensitivity.
Nature communications 04, 2019 | Pubmed ID: 31015402
Bacteria push the limits of chemotactic precision to navigate dynamic chemical gradients.
Proceedings of the National Academy of Sciences of the United States of America May, 2019 | Pubmed ID: 31097577
Bacterial maze runners reveal hidden diversity in chemotactic performance.
Microbial cell (Graz, Austria) Jul, 2019 | Pubmed ID: 31403051
Not Just Going with the Flow: The Effects of Fluid Flow on Bacteria and Plankton.
Annual review of cell and developmental biology 10, 2019 | Pubmed ID: 31412210
Chain formation can enhance the vertical migration of phytoplankton through turbulence.
Science advances 10, 2019 | Pubmed ID: 31663017
On the collision of rods in a quiescent fluid.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2020 | Pubmed ID: 32015116
Bacterial Glycogen Provides Short-Term Benefits in Changing Environments.
Applied and environmental microbiology Apr, 2020 | Pubmed ID: 32111592
Raman-based sorting of microbial cells to link functions to their genes.
Microbial cell (Graz, Austria) Feb, 2020 | Pubmed ID: 32161766
Single-cell bacterial transcription measurements reveal the importance of dimethylsulfoniopropionate (DMSP) hotspots in ocean sulfur cycling.
Nature communications Apr, 2020 | Pubmed ID: 32327645
The effect of flow on swimming bacteria controls the initial colonization of curved surfaces.
Nature communications 06, 2020 | Pubmed ID: 32503979
Bursts Characterize Coagulation of Rods in a Quiescent Fluid.
Physical review letters Jun, 2020 | Pubmed ID: 32639757
Flagellar kinematics reveals the role of environment in shaping sperm motility.
Journal of the Royal Society, Interface 09, 2020 | Pubmed ID: 32900303
PhenoChip: A single-cell phenomic platform for high-throughput photophysiological analyses of microalgae.
Science advances Sep, 2020 | Pubmed ID: 32917592
Constrained optimal foraging by marine bacterioplankton on particulate organic matter.
Proceedings of the National Academy of Sciences of the United States of America 10, 2020 | Pubmed ID: 32973087
Trophic Interactions and the Drivers of Microbial Community Assembly.
Current biology : CB 10, 2020 | Pubmed ID: 33022263
Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization.
Nature communications 10, 2020 | Pubmed ID: 33037214
Optofluidic Raman-activated cell sorting for targeted genome retrieval or cultivation of microbial cells with specific functions.
Nature protocols 02, 2021 | Pubmed ID: 33311714
Environmental fluctuations and their effects on microbial communities, populations and individuals.
FEMS microbiology reviews Aug, 2021 | Pubmed ID: 33338228
Sequential capillarity-assisted particle assembly in a microfluidic channel.
Lab on a chip 03, 2021 | Pubmed ID: 33427254
Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation.
Physical biology Jun, 2021 | Pubmed ID: 33462162
Bistability in oxidative stress response determines the migration behavior of phytoplankton in turbulence.
Proceedings of the National Academy of Sciences of the United States of America 02, 2021 | Pubmed ID: 33495340
An interdisciplinary and application-oriented approach to teach microfluidics.
Biomicrofluidics Jan, 2021 | Pubmed ID: 33537111
ARC: An Open Web-Platform for Request/Supply Matching for a Prioritized and Controlled COVID-19 Response.
Frontiers in public health , 2021 | Pubmed ID: 33665184
Nutrient complexity triggers transitions between solitary and colonial growth in bacterial populations.
The ISME journal 09, 2021 | Pubmed ID: 33731836
Mechanistic model of nutrient uptake explains dichotomy between marine oligotrophic and copiotrophic bacteria.
PLoS computational biology 05, 2021 | Pubmed ID: 34010286
A distinct growth physiology enhances bacterial growth under rapid nutrient fluctuations.
Nature communications 06, 2021 | Pubmed ID: 34135315
Coral mucus rapidly induces chemokinesis and genome-wide transcriptional shifts toward early pathogenesis in a bacterial coral pathogen.
The ISME journal Jun, 2021 | Pubmed ID: 34168314
Using High-Sensitivity Lipidomics To Assess Microscale Heterogeneity in Oceanic Sinking Particles and Single Phytoplankton Cells.
Environmental science & technology Nov, 2021 | Pubmed ID: 34724376
Francesco Carrara1,
Douglas R. Brumley2,
Andrew M. Hein3,
Yutaka Yawata4,5,
M. Mehdi Salek1,
Kang Soo Lee1,
Elzbieta Sliwerska1,
Simon A. Levin6,
Roman Stocker1
1, Institute of Environmental Engineering, Department of Civil, Environmental and Geomatic Engineering,
2School of Mathematics and Statistics, University of Melbourne,
3Institute of Marine Sciences, University of California, Santa Cruz,
4Faculty of Life and Environmental Sciences, University of Tsukuba,
5Microbiology Research Center for Sustainability, University of Tsukuba,
6Department of Ecology and Evolutionary Biology, Princeton University