Christian Gachet

Platelet δ-Storage Pool Disease: An Update.

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation.

Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome.

A central role of GPIb-IX in the procoagulant function of platelets that is independent of the 45-kDa GPIbalpha N-terminal extracellular domain.

Impact of P2Y12 inhibition by clopidogrel on cardiovascular mortality in unselected patients treated by percutaneous coronary angioplasty: a prospective registry.

Cardiovascular mortality in chronic kidney disease patients undergoing percutaneous coronary intervention is mainly related to impaired P2Y12 inhibition by clopidogrel.

Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury.

The antithrombotic activity of EP224283, a neutralizable dual factor Xa inhibitor/glycoprotein IIbIIIa antagonist, exceeds that of the coadministered parent compounds.

Major contribution of the P2Y₁receptor in purinergic regulation of TNFα-induced vascular inflammation.

P2 receptors and platelet function.

Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD.

Association of estimated GFR with platelet inhibition in patients treated with clopidogrel.

P2Y(12) receptors in platelets and other hematopoietic and non-hematopoietic cells.

The extent of P2Y12 inhibition by clopidogrel in diabetes mellitus patients with acute coronary syndrome is not related to glycaemic control: roles of white blood cell count and body weight.

Pathogenic and likely pathogenic variants in at least five genes account for approximately 3% of mild isolated nonsyndromic thrombocytopenia.

Purinergic signaling promotes proliferation of adult mouse subventricular zone cells.

Preserved functional and biochemical characteristics of platelet components prepared with amotosalen and ultraviolet A for pathogen inactivation.

Astrocytes protect neurons against methylmercury via ATP/P2Y(1) receptor-mediated pathways in astrocytes.

Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis.

Involvement of glial P2Y₁ receptors in cognitive deficit after focal cerebral stroke in a rodent model.

Biogenesis of the demarcation membrane system (DMS) in megakaryocytes.

Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells.

FLow-induced PRotrusions (FLIPRs): a platelet-derived platform for the retrieval of microparticles by monocytes and neutrophils.

Proteome changes in platelets after pathogen inactivation--an interlaboratory consensus.

Identification of a new dysfunctional platelet P2Y12 receptor variant associated with bleeding diathesis.

The P2X1 receptor is required for neutrophil extravasation during lipopolysaccharide-induced lethal endotoxemia in mice.

NTPDase2 and the P2Y1 receptor are not required for mammalian eye formation.

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

Dehydration of blood platelets by zeodration: in vitro characterization and hemostatic properties in vivo.

Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach.

Blood Cell Palmitoleate-Palmitate Ratio Is an Independent Prognostic Factor for Amyotrophic Lateral Sclerosis.

Platelets in cancer. From basic research to therapeutic implications.

Purinergic Receptors in Thrombosis and Inflammation.

In Vitro Binding of [³H]PSB-0413 to P2Y₁₂ Receptors.

Time-Dependent Decay of mRNA and Ribosomal RNA during Platelet Aging and Its Correlation with Translation Activity.

[Anti-platelets without a bleeding risk: novel targets and strategies].

Standardization of a well-controlled in vivo mouse model of thrombus formation induced by mechanical injury.

Hemostatic properties and protein expression profile of therapeutic apheresis plasma treated with amotosalen and ultraviolet A for pathogen inactivation.

Coagulation factors bound to procoagulant platelets concentrate in cap structures to promote clotting.

Inherited dysfunctional platelet P2Y receptor mutations associated with bleeding disorders.

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation.

Respective contributions of single and compound granule fusion to secretion by activated platelets.

Platelet integrin 61 controls lung metastasis through direct binding to cancer cell-derived ADAM9.

Dual role of IL-21 in megakaryopoiesis and platelet homeostasis.

Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features.

Platelet Integrins in Tumor Metastasis: Do They Represent a Therapeutic Target?

Amotosalen/UVA pathogen inactivation technology reduces platelet activability, induces apoptosis and accelerates clearance.

The role of extracellular matrix stiffness in megakaryocyte and platelet development and function.

A unique microenvironment in the developing liver supports the expansion of megakaryocyte progenitors.

Immobilized fibrinogen activates human platelets through glycoprotein VI.

Imaging thrombosis with Tc-labeled RAM.1-antibody in vivo.

Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis.

Platelet transfusion: Current challenges.

Inherited platelet disorders : Management of the bleeding risk.

In vitro quality of amotosalen-UVA pathogen-inactivated mini-pool plasma prepared from whole blood stored overnight.

On the way to in vitro platelet production.

Three-Dimensional Culture in a Methylcellulose-Based Hydrogel to Study the Impact of Stiffness on Megakaryocyte Differentiation.

High-Resolution 3D Imaging of Megakaryocytes Using Focused Ion Beam-Scanning Electron Microscopy.

On the Way to Platelet Production.

The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition.

Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface.

An essential role for α4A-tubulin in platelet biogenesis.

The ATP-gated P2X ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice.

Cell surface expression of HLA I molecules as a marker of young platelets.

Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.

Platelet preparation for function testing in the laboratory and clinic: Historical and practical aspects.

Severe bleeding and absent ADP-induced platelet aggregation associated with inherited combined CalDAG-GEFI and P2Y deficiencies.

Use of electron microscopy to study megakaryocytes.

High prevalence of the natural Asn89Asp mutation in the GP1BB gene associated with Bernard-Soulier syndrome in French patients from the genetic isolate of Reunion Island.

Update of P2Y receptor pharmacology: IUPHAR Review 27.

Cytoskeletal-based mechanisms differently regulate and proplatelet formation.

Platelet Purinergic Receptors in Thrombosis and Inflammation.

Pharmacological Blockade of Glycoprotein VI Promotes Thrombus Disaggregation in the Absence of Thrombin.

Megakaryocytes use in vivo podosome-like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids.

Shear rate gradients promote a bi-phasic thrombus formation on weak adhesive proteins, such as fibrinogen in a VWF-dependent manner.

Differential Role of Glycoprotein VI in Mouse and Human Thrombus Progression and Stability.

Removal of citrate from PAS-III additive solution improves functional and biochemical characteristics of buffy-coat platelet concentrates stored for 7 days, with or without INTERCEPT pathogen reduction.

Human platelets labeled at two discrete biotin densities are functional in vitro and are detected in vivo in the murine circulation: A promising approach to monitor platelet survival in vivo in clinical research.

Atypical focal segmental glomerulosclerosis associated with a new PODXL nonsense variant.

CDX2 regulates ACE expression in blood development and leukemia cells.

Correction: An essential role for α4A-tubulin in platelet biogenesis.

Respective roles of Glycoprotein VI and FcγRIIA in the regulation of αIIbβ3-mediated platelet activation to fibrinogen, thrombus buildup, and stability.

Platelet P2Y Receptor Deletion or Pharmacological Inhibition does not Protect Mice from Sepsis or Septic Shock.