第８章
DNA複製 そして 修復
無料サンプル
Free access at this time
塩基対形成とDNA修復
Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a ...
無料サンプル
Free access at this time
DNA複製フォーク
An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped ...
無料サンプル
Free access at this time
ラギングストランド合成
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. ...
無料サンプル
Free access at this time
レプリソーム
DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this ...
無料サンプル
Free access at this time
校正
Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template ...
無料サンプル
Free access at this time
原核生物における複製
DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to the ...
無料サンプル
Free access at this time
真核生物でのレプリケーション
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before ...
無料サンプル
Free access at this time
テロメアとテロメラーゼ
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of ...
無料サンプル
Free access at this time
DNA修復の概要
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a ...
無料サンプル
Free access at this time
ベースエクスキシジョンリペア
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and ...
無料サンプル
Free access at this time
ヌクレオチド除去修復
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV ...
無料サンプル
Free access at this time
ミスマッチ修復
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the ...
無料サンプル
Free access at this time
2本鎖断線の修正
The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the ...
無料サンプル
Free access at this time
相同組換え
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of ...
無料サンプル
Free access at this time
遺伝子変換
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the ...
無料サンプル
Free access at this time
DNA損傷は細胞周期を失速させる可能性があります
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages ...
無料サンプル
Free access at this time
停止したレプリケーション・フォークの再起動
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the ...
Copyright © 2023 MyJoVE Corporation. All rights reserved