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DNA Replikasyonu ve Onarımı

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Baz Eşleştirme ve DNA Onarımı
Baz Eşleştirme ve DNA Onarımı
Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a ...

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DNA Replikasyon Çatalı
DNA Replikasyon Çatalı
An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped ...

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Gecikmeli İplik Sentezi
Gecikmeli İplik Sentezi
During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. ...

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Cevap
Cevap
DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this ...

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Redaksiyon
Redaksiyon
Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template ...

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Prokaryotlarda Replikasyon
Prokaryotlarda Replikasyon
DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to the ...

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Ökaryotlarda Replikasyon
Ökaryotlarda Replikasyon
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before ...

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Telomerler ve Telomeraz
Telomerler ve Telomeraz
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of ...

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DNA Onarımına Genel Bakış
DNA Onarımına Genel Bakış
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a ...

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Baz Eksizyon Onarımı
Baz Eksizyon Onarımı
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and ...

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Nükleotid Eksizyon Onarımı
Nükleotid Eksizyon Onarımı
DNA Distortion and Damage Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV ...

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Uyumsuzluk Onarımı
Uyumsuzluk Onarımı
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the ...

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Çift Telli Kopmaların Sabitlenmesi
Çift Telli Kopmaların Sabitlenmesi
The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the ...

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Homolog Rekombinasyon
Homolog Rekombinasyon
The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of ...

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Gen Dönüşümü
Gen Dönüşümü
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the ...

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DNA Hasarı Hücre Döngüsünü Durdurabilir
DNA Hasarı Hücre Döngüsünü Durdurabilir
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages ...

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Durdurulan Çoğaltma Çatallarını Yeniden Başlatma
Durdurulan Çoğaltma Çatallarını Yeniden Başlatma
DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the ...
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