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JoVE Journal

Genetics

This content is Open Access.

A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information

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05:01 min

July 1st, 2020

July 1st, 2020

3,019 Views

0:05

Introduction

0:32

Genome-Wide Association Study (GWAS) Data Loading

0:57

Load Linkage Disequilibrium (LD) Data Loading

1:26

Single Nucleotide Polymorphism (SNP) Assignment

1:56

Significant Pathway Discovery

2:35

Rugplot Visualization

3:21

Results: Representative GWAS Analyses of Metabolic Pathway Information

4:21

Conclusion

文字起こし

By running the Pathway Association Study Tool (PAST), either through the Shiny application or through the R console, researchers can gain a deeper understanding of the biological meaning of their genome-wide association study (GWAS) results by investigating the metabolic pathways involved.

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