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Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

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06:08 min

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February 10th, 2023

DOI :

10.3791/64535-v

February 10th, 2023

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1,151 Views

Claudia Manriquez Roman¹^,²^,³^,⁴^,⁵, R. Leo Sakemura¹^,², Brooke L. Kimball¹^,², Fang Jin⁶, Roman H. Khadka⁶, Mohamad M. Adada¹^,², Elizabeth L. Siegler¹^,², Aaron J. Johnson⁶, Saad S. Kenderian¹^,²^,⁶

¹T Cell Engineering Laboratory, Mayo Clinic, Rochester, ²Division of Hematology, Mayo Clinic, Rochester, ³Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, ⁴Department of Molecular Medicine, Mayo Clinic, Rochester, ⁵Regenerative Sciences PhD Program, Mayo Clinic, Rochester, ⁶Department of Immunology, Mayo Clinic, Rochester

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CAR T

Acute Lymphoblastic Leukemia

Patient derived Xenograft

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