Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
1.3K Views
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06:08 min
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February 10th, 2023
DOI :
February 10th, 2023
•Claudia Manriquez Roman1,2,3,4,5, R. Leo Sakemura1,2, Brooke L. Kimball1,2, Fang Jin6, Roman H. Khadka6, Mohamad M. Adada1,2, Elizabeth L. Siegler1,2, Aaron J. Johnson6, Saad S. Kenderian1,2,6
1T Cell Engineering Laboratory, Mayo Clinic, Rochester, 2Division of Hematology, Mayo Clinic, Rochester, 3Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, 4Department of Molecular Medicine, Mayo Clinic, Rochester, 5Regenerative Sciences PhD Program, Mayo Clinic, Rochester, 6Department of Immunology, Mayo Clinic, Rochester
Chapters in this video
0:04
Introduction
0:49
Assessment of CART19 Cell‐Associated Toxicities
1:33
MRI Imaging
4:02
Results: Assessment of CART Cell‐Associated Toxicities in a PDX Mice Model
5:17
Conclusion
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