The authors have no acknowledgments.

This study uses the EVIS Exera II endoscopy tower with a BF-UC180F EBUS endoscope (Figure 1) to demonstrate the scope and the Surgical Science Simulator (ENDO mentor suite) with the GI-Bronch Mentor software from Simbionix, Essential EBUS Case 6, when performing the EBUS procedure in the simulation-based setting. No patients are included in the study as the entire procedure is performed on the Surgical Science Simulator (ENDO mentor suite). Prior to the EBUS procedure, a complete bronchoscop...

Simulation-Based Training of EBUS-TBNA

<ol>
	<li>WHO. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cancer.">Cancer.</a> , (2022).</li><li>Kutob, L., Schneider, F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Lung+cancer+staging.">Lung cancer staging.</a> Surgical Pathology Clinics. 13 (1), 57-71 (2020).</li><li>Vilmann, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Combined+endobronchial+and+esophageal+endosonography+for+the+diagnosis+and+staging+of+lung+cancer:+European+Society+of+Gastrointestinal+Endoscopy+(ESGE)+Guideline,+in+cooperation+with+the+European+Respiratory+Society+(ERS)+and+the+European+Society+of+Thoracic+Surgeons+(ESTS).">Combined endobronchial and esophageal endosonography for the diagnosis and staging of lung cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline, in cooperation with the European Respiratory Society (ERS) and the European Society of Thoracic Surgeons (ESTS).</a> Endoscopy. 47 (6), 545-559 (2015).</li><li>Konge, L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Simulator+training+for+endobronchial+ultrasound:+a+randomised+controlled+trial.">Simulator training for endobronchial ultrasound: a randomised controlled trial.</a> European Respiratory Journal. 46 (4), 1140-1149 (2015).</li><li>Liam, C. K., Lee, P., Yu, C. J., Bai, C., Yasufuku, K. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+diagnosis+of+lung+cancer+in+the+era+of+interventional+pulmonology.">The diagnosis of lung cancer in the era of interventional pulmonology.</a> International Journal of Tuberculosis and Lung Disease. 25 (1), 6-15 (2021).</li><li>Clementsen, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Diagnosis+and+staging+of+lung+cancer+with+the+use+of+one+single+echoendoscope+in+both+the+trachea+and+the+esophagus:+A+practical+guide.">Diagnosis and staging of lung cancer with the use of one single echoendoscope in both the trachea and the esophagus: A practical guide.</a> Journal of Endoscopic Ultrasound. 10 (5), 325-334 (2021).</li><li>Farr, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Endobronchial+ultrasound:+launch+of+an+ERS+structured+training+programme.">Endobronchial ultrasound: launch of an ERS structured training programme.</a> Breathe (Sheffield, England). 12 (3), 217-220 (2016).</li><li>Konge, L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+Simulation+Centre+at+Rigshospitalet,+Copenhagen,+Denmark.">The Simulation Centre at Rigshospitalet, Copenhagen, Denmark.</a> Journal of Surgical Education. 72 (2), 362-365 (2015).</li><li>Jenssen, C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Ultrasound+techniques+in+the+evaluation+of+the+mediastinum,+part+2:+mediastinal+lymph+node+anatomy+and+diagnostic+reach+of+ultrasound+techniques,+clinical+work+up+of+neoplastic+and+inflammatory+mediastinal+lymphadenopathy+using+ultrasound+techniques+and+how+to+learn+mediastinal+endosonography.">Ultrasound techniques in the evaluation of the mediastinum, part 2: mediastinal lymph node anatomy and diagnostic reach of ultrasound techniques, clinical work up of neoplastic and inflammatory mediastinal lymphadenopathy using ultrasound techniques and how to learn mediastinal endosonography.</a> Journal of Thoracic Diseases. 7 (10), 439-458 (2015).</li><li>Lee, H. S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Real-time+endobronchial+ultrasound-guided+transbronchial+needle+aspiration+in+mediastinal+staging+of+non-small+cell+lung+cancer:+how+many+aspirations+per+target+lymph+node+station.">Real-time endobronchial ultrasound-guided transbronchial needle aspiration in mediastinal staging of non-small cell lung cancer: how many aspirations per target lymph node station.</a> Chest. 134 (2), 368-374 (2008).</li><li>Kinsey, C. M., Arenberg, D. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Endobronchial+ultrasound-guided+transbronchial+needle+aspiration+for+non-small+cell+lung+cancer+staging.">Endobronchial ultrasound-guided transbronchial needle aspiration for non-small cell lung cancer staging.</a> American Journal of Respiratory and Critical Care Medicine. 189 (6), 640-649 (2014).</li><li>Sanz-Santos, J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Systematic+compared+with+targeted+staging+with+endobronchial+ultrasound+in+patients+with+lung+cancer.">Systematic compared with targeted staging with endobronchial ultrasound in patients with lung cancer.</a> Annals of Thoracic Surgery. 106 (2), 398-403 (2018).</li><li>Crombag, L. M. M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Systematic+and+combined+endosonographic+staging+of+lung+cancer+(SCORE+study).">Systematic and combined endosonographic staging of lung cancer (SCORE study).</a> The European Respiratory Journal. 53 (2), 1800800 (2019).</li><li>Andersen, A. G., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Preparing+for+reality:+A+randomized+trial+on+immersive+virtual+reality+for+bronchoscopy+training.">Preparing for reality: A randomized trial on immersive virtual reality for bronchoscopy training.</a> Respiration. 102 (4), 316-323 (2023).</li><li>Naur, T. M. H., Nilsson, P. M., Pietersen, P. I., Clementsen, P. F., Konge, L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Simulation-based+training+in+flexible+bronchoscopy+and+endobronchial+ultrasound-guided+transbronchial+needle+aspiration+(EBUS-TBNA):+A+systematic+review.">Simulation-based training in flexible bronchoscopy and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): A systematic review.</a> Respiration. 93 (5), 355-362 (2017).</li><li>Konge, L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Reliable+and+valid+assessment+of+clinical+bronchoscopy+performance.">Reliable and valid assessment of clinical bronchoscopy performance.</a> Respiration. 83 (1), 53-60 (2012).</li><li>Du Rand, I. A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=British+Thoracic+Society+guideline+for+diagnostic+flexible+bronchoscopy+in+adults:+accredited+by+NICE.">British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE.</a> Thorax. 68 (Suppl 1), 1-44 (2013).</li><li>Nilsson, P. M., Naur, T. M. H., Clementsen, P. F., Konge, L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Simulation+in+bronchoscopy:+current+and+future+perspectives.">Simulation in bronchoscopy: current and future perspectives.</a> Advances in Medical Education and Practice. 8, 755-760 (2017).</li><li>Cold, K. M., Clementsen, P. F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Diagnosis+and+staging+of+lung+cancer+using+transesophageal+ultrasound:+Training+and+assessment.">Diagnosis and staging of lung cancer using transesophageal ultrasound: Training and assessment.</a> Journal of Endoscopic Ultrasound. 11 (2), 92-94 (2022).</li><li>Korevaar, D. A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Added+value+of+combined+endobronchial+and+oesophageal+endosonography+for+mediastinal+nodal+staging+in+lung+cancer:+a+systematic+review+and+meta-analysis.">Added value of combined endobronchial and oesophageal endosonography for mediastinal nodal staging in lung cancer: a systematic review and meta-analysis.</a> Lancet Respiratory Medicine. 4 (12), 960-968 (2016).</li></ol>

The authors have nothing to disclose.

We hereby propose a systematic approach to the EBUS-TBNA procedure by splitting the anatomy into six landmarks to help guide the endoscopist through the bronchial maze. Furthermore, we demonstrate how to perform needle aspiration in a systematic way possible to repeat every time to standardize the procedure.
Even though the simulation-based setting is a safe environment, the endoscopist should be aware of some critical steps in the procedure. Initially, it is important to know the oblique angl...

Lung cancer is one of the most common cancers worldwide with 2.21 million cases in 2020, and the most frequent cause of cancer death with 1.80 million deaths in 20201. As with most cancers, fast and accurate diagnosis of lung cancer is crucial to be able to offer the best treatment, which in cases with a localized disease with no or little spreading to mediastinal lymph nodes can be surgical removal of the tumor. In order to be able to confirm or invalidate the suspicion of malignancy and to determine the Tumor-Node-Metastasis (TNM)-classification if lung cancer is confirmed2, it is extremely important to have good and representative biopsies from the suspected tumor or lymph nodes.
Among the invasive techniques, flexible bronchoscopy combined with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) plays a key role3. However, it is a complex technical procedure, and the success is dependent on the competence of the operator4. Anatomic orientation can easily be lost if the endoscopist does not know the anatomy of the mediastinum. Knowledge of endosonographic anatomy and its relation to the TNM lung cancer classification system is therefore crucial. In the case of lung cancer, if no tumor cells are found in any lymph node stations, the disease is classified as N0 disease and is often operable and thus, potentially curable. In the case of a right-sided lung tumor, the disease is classified as N1 disease if tumor cells are solely found in station 10R and could be operable and thus potentially curable. However, if tumor cells are found in station 4R, the disease is classified as N2 disease, and the patient can only be offered life-prolonging chemotherapy5. Three borders should therefore be remembered as they are important for treatment and prognosis.
(i)The left border of the trachea is the border between stations 4R and 4L. 
(ii)The upper border of the left pulmonary artery is the border between stations 4L and 10L. 
(iii)The lower border of the azygos vein is the border between stations 4R and 10R6.
To be qualified to perform EBUS-TBNA in the diagnostic process of possible lung cancer, it is therefore essential that EBUS-TBNA is thoroughly trained in a simulator-based setting based on a structured training curriculum before being performed on patients. Therefore, a stepwise approach relying on the six anatomical landmarks is used in the EBUS-certified training program offered by the European Respiratory Society (ERS)7.
We demonstrate the stepwise structured guide in a simulation-based setting at Copenhagen Academy for Medical Education and Simulation (CAMES), Denmark8, on how to perform EBUS-TBNA with the EBUS endoscope relying on the six anatomical landmarks9 as a guide.

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>EVIS Exera II endoscopy tower with a BF-UC180F EBUS endoscope</td>
			<td>Olympus</td>
			<td>https://medical.olympusamerica.com/products/bf-uc180f-ebus-bronchoscope</td>
			<td></td>
		</tr>
		<tr>
			<td>ENDO mentor suite</td>
			<td>Surgical Science</td>
			<td>https://simbionix.com/endo-mentor-suite/</td>
			<td>Surgical Science Simulator</td>
		</tr>
		<tr>
			<td>GI-Bronch Mentor software</td>
			<td>Simbionix</td>
			<td>https://simbionix.com/simulators/gi-mentor/</td>
			<td></td>
		</tr>
	</tbody>
</table>

systematic endobronchial ultrasound - the six landmarks approach

Lung cancer is the leading cause of cancer mortality globally. To ensure the correct diagnosis and staging in relation to treatment options, it is crucial to obtain valid biopsies from suspected tumors and mediastinal lymph nodes and accurate identification of the mediastinal lymph nodes regarding the Tumor-Node-Metastasis (TNM)-classification. Flexible bronchoscopy combined with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is essential in the workup and diagnosis of patients suspected of lung cancer. EBUS-TBNA from mediastinal lymph nodes is a technically difficult procedure and has been identified as one of the most important procedures that should be integrated into a simulation-based training program for invasive pulmonologists. More specific guidelines that govern training in EBUS-TBNA are needed to meet this demand. We hereby propose a systematic, stepwise approach with specific attention to six landmarks that support the endoscopist when navigating through the bronchial maze. The stepwise approach relying on the six landmarks is used in the EBUS-certified training program offered by the European Respiratory Society (ERS).

Author Spotlight: Demonstrating Systematic Endobronchial Ultrasound to New Endoscopists 

Systematic Endobronchial Ultrasound - The Six Landmarks Approach

We want to demonstrate a Stepwise structured guide on how to perform the EBUS procedure with the endoscope in a simulation-based setting, relying on the six anatomical landmarks approach. Training of invasive procedures in simulation-based settings has become widely increased worldwide within the field of medicine and surgery to ensure that the professionals practice in simulators before performing the invasive procedures in patients. The most important technology is that we use the EBUS endoscope in the esophagus, the so-called USB, because we know that the combination of EBUS and USB is much better than EBUS alone.Training of invasive procedures in simulation-based settings should be the golden standard. However, many professionals do not have access to these training facilities, or do not prioritize to train. So our current experimental challenge is to spread the knowledge of these simulation-based settings and facilitate training to as many as possible.

The above-mentioned structured approach to an EBUS-TBNA procedure has been taught at CAMES since 2016 as part of the EBUS-certified training program offered by the European Respiratory Society (ERS)7. The 6 landmarks approach is based on a validated assessment tool for measuring competency in EBUS-guided transbronchial needle aspiration4. By performing EBUS-TBNA in a structured way, as shown above, no important lymph nodes will be missed, and the diagnostic accuracy will be...

Watch this Scientific Journal Video about Demonstrating Systematic Endobronchial Ultrasound to New Endoscopists at JoVE.com

Endobronchial ultrasound-guided sampling using transbronchial needle aspiration plays a key role in staging and diagnosing lung cancer. We propose a systematic stepwise approach dividing the procedure into six landmarks that should be taught to new operators.

Lung cancer is the leading cause of cancer mortality globally. To ensure the correct diagnosis and staging in relation to treatment options, it is crucial ...

systematic-endobronchial-ultrasound-the-six-landmarks-approach

Research

JoVE Journal

Cancer Research

1.3K ビュー.  Rigshospitalet, University of Copenhagen. 6つの解剖学的ランドマークアプローチに頼って、シミュレーションベースの設定で内視鏡を使用してEBUS手順を実行する方法について、段階的に構造化されたガイドを実証したいと思います。シミュレーションベースの環境での侵襲的処置のトレーニングは、専門家が患者に侵襲的処置を行う前にシミュレーターで練習することを確実にするために、医学および外科の分...