Department of Cardiology
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Structural characterization of the mouse Girk genes.
Gene Feb, 2002 | Pubmed ID: 11891065
NFAT transcription factors are critical survival factors that inhibit cardiomyocyte apoptosis during phenylephrine stimulation in vitro.
Circulation research Apr, 2003 | Pubmed ID: 12663489
Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos.
Circulation research Oct, 2003 | Pubmed ID: 14551244
GATA4 is a dosage-sensitive regulator of cardiac morphogenesis.
Developmental biology Nov, 2004 | Pubmed ID: 15464586
Morphogenesis of the right ventricle requires myocardial expression of Gata4.
The Journal of clinical investigation Jun, 2005 | Pubmed ID: 15902305
Transcription factor gata4 regulates cardiac BCL2 gene expression in vitro and in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Apr, 2006 | Pubmed ID: 16469847
Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase.
Journal of cardiac failure Jun, 2006 | Pubmed ID: 16762803
Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition.
Circulation research Aug, 2006 | Pubmed ID: 16857965
A multivariate approach for integrating genome-wide expression data and biological knowledge.
Bioinformatics (Oxford, England) Oct, 2006 | Pubmed ID: 16877751
Development of heart valves requires Gata4 expression in endothelial-derived cells.
Development (Cambridge, England) Sep, 2006 | Pubmed ID: 16914500
Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine.
Molecular and cellular biology Dec, 2006 | Pubmed ID: 16940177
Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2006 | Pubmed ID: 16983087
Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects.
Developmental biology Jan, 2007 | Pubmed ID: 17069789
Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes.
American journal of physiology. Heart and circulatory physiology Jul, 2007 | Pubmed ID: 17468330
Spectrum of heart disease associated with murine and human GATA4 mutation.
Journal of molecular and cellular cardiology Dec, 2007 | Pubmed ID: 17643447
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis.
Nature medicine Aug, 2007 | Pubmed ID: 17660828
Altered microRNA expression in human heart disease.
Physiological genomics Nov, 2007 | Pubmed ID: 17712037
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart.
Nature Jul, 2008 | Pubmed ID: 18568026
GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium.
Molecular and cellular biology Sep, 2008 | Pubmed ID: 18591257
Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium.
Biochemical and biophysical research communications Oct, 2008 | Pubmed ID: 18722343
More than a cover: epicardium as a novel source of cardiac progenitor cells.
Regenerative medicine Sep, 2008 | Pubmed ID: 18729786
Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity.
Developmental biology Nov, 2008 | Pubmed ID: 18775691
Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations.
Circulation research Dec, 2008 | Pubmed ID: 18948621
MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes.
Molecular and cellular biology Apr, 2009 | Pubmed ID: 19188439
Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart.
The Journal of clinical investigation Jun, 2009 | Pubmed ID: 19411759
Identification of a cardiac disease modifier gene using forward genetics in the mouse.
PLoS genetics Sep, 2009 | Pubmed ID: 19763163
Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse.
Genesis (New York, N.Y. : 2000) Jan, 2010 | Pubmed ID: 20014345
Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart.
Developmental biology Feb, 2010 | Pubmed ID: 20025864
Heart failure-associated changes in RNA splicing of sarcomere genes.
Circulation. Cardiovascular genetics Apr, 2010 | Pubmed ID: 20124440
Expression and function of microRNAs in heart disease.
Current drug targets Aug, 2010 | Pubmed ID: 20415651
Dissecting spatio-temporal protein networks driving human heart development and related disorders.
Molecular systems biology Jun, 2010 | Pubmed ID: 20571530
Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine.
Gut Jul, 2010 | Pubmed ID: 20581237
Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death.
Journal of molecular and cellular cardiology Nov, 2010 | Pubmed ID: 20708014
Genome-wide location analysis by pull down of in vivo biotinylated transcription factors.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] Oct, 2010 | Pubmed ID: 20890903
CompleteMOTIFs: DNA motif discovery platform for transcription factor binding experiments.
Bioinformatics (Oxford, England) Mar, 2011 | Pubmed ID: 21183585
Reprogramming fibroblasts into cardiomyocytes.
The New England journal of medicine Jan, 2011 | Pubmed ID: 21226585
Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver.
Hepatology (Baltimore, Md.) Mar, 2011 | Pubmed ID: 21294146
Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]
Proceedings of the National Academy of Sciences of the United States of America Mar, 2011 | Pubmed ID: 21330551
A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis.
The Journal of clinical investigation Apr, 2011 | Pubmed ID: 21364285
Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2011 | Pubmed ID: 21415370
Adult mouse epicardium modulates myocardial injury by secreting paracrine factors.
The Journal of clinical investigation May, 2011 | Pubmed ID: 21505261
De novo cardiomyocytes from within the activated adult heart after injury.
Nature Jun, 2011 | Pubmed ID: 21654746
WT1 regulates epicardial epithelial to mesenchymal transition through β-catenin and retinoic acid signaling pathways.
Developmental biology Aug, 2011 | Pubmed ID: 21663736
Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2011 | Pubmed ID: 21746915
miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation.
The Journal of biological chemistry Oct, 2011 | Pubmed ID: 21868385
Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes.
Journal of molecular and cellular cardiology Jan, 2012 | Pubmed ID: 21907210
Epicardial epithelial-to-mesenchymal transition in injured heart.
Journal of cellular and molecular medicine Dec, 2011 | Pubmed ID: 21914126
Adult cardiac-resident MSC-like stem cells with a proepicardial origin.
Cell stem cell Dec, 2011 | Pubmed ID: 22136928
Polycomb repressive complex 2 regulates normal development of the mouse heart.
Circulation research Feb, 2012 | Pubmed ID: 22158708
PRC2 directly methylates GATA4 and represses its transcriptional activity.
Genes & development Jan, 2012 | Pubmed ID: 22215809
Isolation and characterization of embryonic and adult epicardium and epicardium-derived cells.
Methods in molecular biology (Clifton, N.J.) , 2012 | Pubmed ID: 22222530
Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy.
The Journal of biological chemistry Mar, 2012 | Pubmed ID: 22228770
YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2012 | Pubmed ID: 22308401
CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy.
Circulation research Mar, 2012 | Pubmed ID: 22343712
Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4.
Molecular and cellular biology May, 2012 | Pubmed ID: 22431517
Regulation of GATA4 transcriptional activity in cardiovascular development and disease.
Current topics in developmental biology , 2012 | Pubmed ID: 22449843
Equal modulation of endothelial cell function by four distinct tissue-specific mesenchymal stem cells.
Angiogenesis Sep, 2012 | Pubmed ID: 22527199
Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo.
PLoS genetics May, 2012 | Pubmed ID: 22589735
Endocardial and epicardial epithelial to mesenchymal transitions in heart development and disease.
Circulation research Jun, 2012 | Pubmed ID: 22679138
Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2012 | Pubmed ID: 22733742
Mature cardiomyocytes recall their progenitor experience via polycomb repressive complex 2.
Circulation research Jul, 2012 | Pubmed ID: 22773425
Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2012 | Pubmed ID: 22904188
Myocardial regeneration: expanding the repertoire of thymosin β4 in the ischemic heart.
Annals of the New York Academy of Sciences Oct, 2012 | Pubmed ID: 23045976
Genetic Cre-loxP assessment of epicardial cell fate using Wt1-driven Cre alleles.
Circulation research Nov, 2012 | Pubmed ID: 23139287
A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity.
Genome research Jun, 2013 | Pubmed ID: 23547170
Timing of myocardial trpm7 deletion during cardiogenesis variably disrupts adult ventricular function, conduction, and repolarization.
Circulation Jul, 2013 | Pubmed ID: 23734001
The mysterious origins of coronary vessels.
Cell research Sep, 2013 | Pubmed ID: 23835479
A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds.
Scientific reports , 2013 | Pubmed ID: 23873182
HCN4 charges up the first heart field.
Circulation research Aug, 2013 | Pubmed ID: 23908325
Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2013 | Pubmed ID: 24003143
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction.
Nature biotechnology Oct, 2013 | Pubmed ID: 24013197
Developing insights into cardiac regeneration.
Development (Cambridge, England) Oct, 2013 | Pubmed ID: 24046314
WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland.
Developmental cell Oct, 2013 | Pubmed ID: 24135228
Peritruncal coronary endothelial cells contribute to proximal coronary artery stems and their aortic orifices in the mouse heart.
PloS one , 2013 | Pubmed ID: 24278332
GATA factors promote ER integrity and β-cell survival and contribute to type 1 diabetes risk.
Molecular endocrinology (Baltimore, Md.) Jan, 2014 | Pubmed ID: 24284823
Hippo activation in arrhythmogenic cardiomyopathy.
Circulation research Jan, 2014 | Pubmed ID: 24481838
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies.
Nature medicine Jun, 2014 | Pubmed ID: 24813252
Yap1 is required for endothelial to mesenchymal transition of the atrioventricular cushion.
The Journal of biological chemistry Jul, 2014 | Pubmed ID: 24831012
Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model.
Circulation research Jul, 2014 | Pubmed ID: 24833660
Notching up vascular regeneration.
Cell research Jul, 2014 | Pubmed ID: 24853955
Harnessing Hippo in the heart: Hippo/Yap signaling and applications to heart regeneration and rejuvenation.
Stem cell research May, 2014 | Pubmed ID: 24881775
Strategies for cardiac regeneration and repair.
Science translational medicine Jun, 2014 | Pubmed ID: 24898748
Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart.
Science (New York, N.Y.) Jul, 2014 | Pubmed ID: 24994653
Optimization of genome engineering approaches with the CRISPR/Cas9 system.
PloS one , 2014 | Pubmed ID: 25166277
Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease.
Nature communications Sep, 2014 | Pubmed ID: 25249388
Pi3kcb links Hippo-YAP and PI3K-AKT signaling pathways to promote cardiomyocyte proliferation and survival.
Circulation research Jan, 2015 | Pubmed ID: 25249570
Epicardium-to-fat transition in injured heart.
Cell research Nov, 2014 | Pubmed ID: 25257468
Insights into the genetic structure of congenital heart disease from human and murine studies on monogenic disorders.
Cold Spring Harbor perspectives in medicine Oct, 2014 | Pubmed ID: 25274754
Introduction to the special issue on heart regeneration and rejuvenation.
Stem cell research Nov, 2014 | Pubmed ID: 25459518
Releasing YAP from an α-catenin trap increases cardiomyocyte proliferation.
Circulation research Jan, 2015 | Pubmed ID: 25552687
Cellular origin and developmental program of coronary angiogenesis.
Circulation research Jan, 2015 | Pubmed ID: 25634974
Novel Roles of GATA4/6 in the Postnatal Heart Identified through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase.
PloS one , 2015 | Pubmed ID: 26023924
Trbp regulates heart function through microRNA-mediated Sox6 repression.
Nature genetics Jul, 2015 | Pubmed ID: 26029872
Contribution of Fetal, but Not Adult, Pulmonary Mesothelium to Mesenchymal Lineages in Lung Homeostasis and Fibrosis.
American journal of respiratory cell and molecular biology Feb, 2016 | Pubmed ID: 26121126
Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2015 | Pubmed ID: 26243880
Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction.
PloS one , 2015 | Pubmed ID: 26390289
SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth.
Science signaling Sep, 2015 | Pubmed ID: 26396267
Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis.
The Journal of clinical investigation Nov, 2015 | Pubmed ID: 26436652
Recounting Cardiac Cellular Composition.
Circulation research Feb, 2016 | Pubmed ID: 26846633
Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart.
Developmental biology May, 2016 | Pubmed ID: 26988120
Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types.
Genome biology Jun, 2016 | Pubmed ID: 27259512
Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy.
Cardiovascular research Aug, 2016 | Pubmed ID: 27557636
Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth.
Developmental cell Nov, 2016 | Pubmed ID: 27720608
An IGF1R-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury.
Circulation Nov, 2016 | Pubmed ID: 27803039
Modeling Inherited Arrhythmia Disorders Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Circulation journal : official journal of the Japanese Circulation Society Dec, 2016 | Pubmed ID: 27916777
Efficient, footprint-free human iPSC genome editing by consolidation of Cas9/CRISPR and piggyBac technologies.
Nature protocols Jan, 2017 | Pubmed ID: 27929521
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