Howard Hughes Medical Institute,
Laboratory of RNA Molecular Biology,
Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology
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Expanding small RNA interference.
Nature biotechnology May, 2002 | Pubmed ID: 11981553
Identification of tissue-specific microRNAs from mouse.
Current biology : CB Apr, 2002 | Pubmed ID: 12007417
Analysis of gene function in somatic mammalian cells using small interfering RNAs.
Methods (San Diego, Calif.) Feb, 2002 | Pubmed ID: 12054897
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.
Cell Sep, 2002 | Pubmed ID: 12230974
Functional genomics: RNA sets the standard.
Nature Jan, 2003 | Pubmed ID: 12529623
New microRNAs from mouse and human.
RNA (New York, N.Y.) Feb, 2003 | Pubmed ID: 12554859
A uniform system for microRNA annotation.
RNA (New York, N.Y.) Mar, 2003 | Pubmed ID: 12592000
Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing.
Antisense & nucleic acid drug development Apr, 2003 | Pubmed ID: 12804036
The small RNA profile during Drosophila melanogaster development.
Developmental cell Aug, 2003 | Pubmed ID: 12919683
Analysis of mammalian gene function using small interfering RNAs.
Nucleic acids research. Supplement (2001) , 2003 | Pubmed ID: 14510516
MicroRNA targets in Drosophila.
Genome biology , 2003 | Pubmed ID: 14709173
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.
RNA (New York, N.Y.) Mar, 2004 | Pubmed ID: 14970398
Small interfering RNAs: a revolutionary tool for the analysis of gene function and gene therapy.
Molecular interventions Jun, 2002 | Pubmed ID: 14993376
siRNAs: applications in functional genomics and potential as therapeutics.
Nature reviews. Drug discovery Apr, 2004 | Pubmed ID: 15060527
RISC is a 5' phosphomonoester-producing RNA endonuclease.
Genes & development May, 2004 | Pubmed ID: 15105377
Identification of virus-encoded microRNAs.
Science (New York, N.Y.) Apr, 2004 | Pubmed ID: 15118162
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.
RNA (New York, N.Y.) Jun, 2004 | Pubmed ID: 15146077
siRNA Selection Server: an automated siRNA oligonucleotide prediction server.
Nucleic acids research Jul, 2004 | Pubmed ID: 15215365
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
Molecular cell Jul, 2004 | Pubmed ID: 15260970
RNA interference by osmotic lysis of pinosomes: liposome-independent transfection of siRNAs into mammalian cells.
BioTechniques Jul, 2004 | Pubmed ID: 15283206
Mechanisms of gene silencing by double-stranded RNA.
Nature Sep, 2004 | Pubmed ID: 15372041
Human MicroRNA targets.
PLoS biology Nov, 2004 | Pubmed ID: 15502875
A pancreatic islet-specific microRNA regulates insulin secretion.
Nature Nov, 2004 | Pubmed ID: 15538371
The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis.
Current biology : CB Dec, 2004 | Pubmed ID: 15589161
Endogenous MHC class II processing of a viral nuclear antigen after autophagy.
Science (New York, N.Y.) Jan, 2005 | Pubmed ID: 15591165
Identification of microRNAs of the herpesvirus family.
Nature methods Apr, 2005 | Pubmed ID: 15782219
Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein.
Nature Mar, 2005 | Pubmed ID: 15800629
Clustering and conservation patterns of human microRNAs.
Nucleic acids research , 2005 | Pubmed ID: 15891114
The developmental miRNA profiles of zebrafish as determined by small RNA cloning.
Genes & development Jun, 2005 | Pubmed ID: 15937218
Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development.
Cell Jul, 2005 | Pubmed ID: 15989958
Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage.
Molecular cell Aug, 2005 | Pubmed ID: 16061186
Identification and characterization of small RNAs involved in RNA silencing.
FEBS letters Oct, 2005 | Pubmed ID: 16153643
Silencing of microRNAs in vivo with 'antagomirs'.
Nature Dec, 2005 | Pubmed ID: 16258535
Identification of clustered microRNAs using an ab initio prediction method.
BMC bioinformatics , 2005 | Pubmed ID: 16274478
Identification of novel argonaute-associated proteins.
Current biology : CB Dec, 2005 | Pubmed ID: 16289642
A novel class of small RNAs bind to MILI protein in mouse testes.
Nature Jul, 2006 | Pubmed ID: 16751777
On the art of identifying effective and specific siRNAs.
Nature methods Sep, 2006 | Pubmed ID: 16929310
A potential protein-RNA recognition event along the RISC-loading pathway from the structure of A. aeolicus Argonaute with externally bound siRNA.
Structure (London, England : 1993) Oct, 2006 | Pubmed ID: 17027504
Specific RNAi mediated gene knockdown in zebrafish cell lines.
RNA biology Jul-Sep, 2005 | Pubmed ID: 17114924
Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs.
RNA biology Apr, 2006 | Pubmed ID: 17114944
Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense.
Genes & development Dec, 2006 | Pubmed ID: 17158744
Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia.
Blood Jun, 2007 | Pubmed ID: 17327404
Specificity, duplex degradation and subcellular localization of antagomirs.
Nucleic acids research , 2007 | Pubmed ID: 17439965
A mammalian microRNA expression atlas based on small RNA library sequencing.
Cell Jun, 2007 | Pubmed ID: 17604727
Cellular cofactors affecting hepatitis C virus infection and replication.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2007 | Pubmed ID: 17616579
Reactions of phosphate and phosphorothiolate diesters with nucleophiles: comparison of transition state structures.
Organic & biomolecular chemistry Aug, 2007 | Pubmed ID: 17637971
Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline.
Nucleic acids research , 2007 | Pubmed ID: 17702759
Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity.
RNA (New York, N.Y.) Feb, 2008 | Pubmed ID: 18094121
Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing.
Methods (San Diego, Calif.) Jan, 2008 | Pubmed ID: 18158127
Cloning of small RNA molecules.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] Nov, 2005 | Pubmed ID: 18265364
The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members.
Development (Cambridge, England) Apr, 2008 | Pubmed ID: 18287206
MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase.
Immunity May, 2008 | Pubmed ID: 18450484
MicroRNA-mediated down-regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg cells: a potential pathogenetic lesion in Hodgkin lymphomas.
The American journal of pathology Jul, 2008 | Pubmed ID: 18583325
Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype.
The American journal of pathology Sep, 2008 | Pubmed ID: 18688024
Structure of the guide-strand-containing argonaute silencing complex.
Nature Nov, 2008 | Pubmed ID: 18754009
Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs.
RNA (New York, N.Y.) Dec, 2008 | Pubmed ID: 18978028
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.
Nature Dec, 2008 | Pubmed ID: 19043405
A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways.
Molecular and cellular biology Feb, 2009 | Pubmed ID: 19047376
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex.
Nature Dec, 2008 | Pubmed ID: 19092929
DGCR8-dependent microRNA biogenesis is essential for skin development.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2009 | Pubmed ID: 19114655
miRNA in situ hybridization in formaldehyde and EDC-fixed tissues.
Nature methods Feb, 2009 | Pubmed ID: 19137005
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo.
Genes & development Jun, 2009 | Pubmed ID: 19487573
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Immunity Jul, 2009 | Pubmed ID: 19576794
The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation.
The Journal of clinical investigation Aug, 2009 | Pubmed ID: 19620785
Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB.
Neuron Sep, 2009 | Pubmed ID: 19778509
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature Oct, 2009 | Pubmed ID: 19812667
Absolute quantification of microRNAs by using a universal reference.
RNA (New York, N.Y.) Dec, 2009 | Pubmed ID: 19861428
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.
Cell Apr, 2010 | Pubmed ID: 20371350
Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo.
The European journal of neuroscience Feb, 2010 | Pubmed ID: 20384810
Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I.
Nature structural & molecular biology Jul, 2010 | Pubmed ID: 20581823
miRNAs in human cancer.
The Journal of pathology Jan, 2011 | Pubmed ID: 21125669
MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC.
PloS one , 2011 | Pubmed ID: 21283765
Combined characterization of microRNA and mRNA profiles delineates early differentiation pathways of CD133+ and CD34+ hematopoietic stem and progenitor cells.
Stem cells (Dayton, Ohio) May, 2011 | Pubmed ID: 21394831
Deep sequencing of small RNAs specifically associated with Arabidopsis AGO1 and AGO4 uncovers new AGO functions.
The Plant journal : for cell and molecular biology Jul, 2011 | Pubmed ID: 21457371
Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.
Nature structural & molecular biology Jun, 2011 | Pubmed ID: 21552261
MicroRNA sequence and expression analysis in breast tumors by deep sequencing.
Cancer research Jul, 2011 | Pubmed ID: 21586611
Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma.
Cancer research Sep, 2011 | Pubmed ID: 21693658
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability.
Molecular cell Aug, 2011 | Pubmed ID: 21723170
RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries.
RNA (New York, N.Y.) Sep, 2011 | Pubmed ID: 21775473
MicroRNA-24 regulates vascularity after myocardial infarction.
Circulation Aug, 2011 | Pubmed ID: 21788589
FOXO1 is an essential regulator of pluripotency in human embryonic stem cells.
Nature cell biology Sep, 2011 | Pubmed ID: 21804543
Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.
Genes & development Oct, 2011 | Pubmed ID: 22012620
New insights in the mechanism of microRNA-mediated target repression.
Nature structural & molecular biology Nov, 2011 | Pubmed ID: 22056803
RNA targets of wild-type and mutant FET family proteins.
Nature structural & molecular biology Dec, 2011 | Pubmed ID: 22081015
Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.
Cell host & microbe Nov, 2011 | Pubmed ID: 22100165
Identification of RNA-protein interaction networks using PAR-CLIP.
Wiley interdisciplinary reviews. RNA Dec, 2011 | Pubmed ID: 22213601
The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines.
PLoS pathogens Jan, 2012 | Pubmed ID: 22291592
Markus Hafner1,
Markus Landthaler2,
Lukas Burger3,
Mohsen Khorshid3,
Jean Hausser4,
Philipp Berninger4,
Andrea Rothballer1,
Manuel Ascano1,
Anna-Carina Jungkamp2,
Mathias Munschauer2,
Alexander Ulrich1,
Greg S. Wardle1,
Scott Dewell5,
Mihaela Zavolan3,
Thomas Tuschl1
1Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, Rockefeller University,
2Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine,
3, Biozentrum der Universität Basel and Swiss Institute of Bioinformatics (SIB),
4, Biozentrum der Universität Basel and Swiss Institute of Bioinformatics (SIB),
5Genomics Resource Center, Rockefeller University
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