Thomas Tuschl

Expanding small RNA interference.

Identification of tissue-specific microRNAs from mouse.

Analysis of gene function in somatic mammalian cells using small interfering RNAs.

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi.

Functional genomics: RNA sets the standard.

New microRNAs from mouse and human.

A uniform system for microRNA annotation.

Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing.

The small RNA profile during Drosophila melanogaster development.

Analysis of mammalian gene function using small interfering RNAs.

MicroRNA targets in Drosophila.

Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.

Small interfering RNAs: a revolutionary tool for the analysis of gene function and gene therapy.

siRNAs: applications in functional genomics and potential as therapeutics.

RISC is a 5' phosphomonoester-producing RNA endonuclease.

Identification of virus-encoded microRNAs.

The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.

siRNA Selection Server: an automated siRNA oligonucleotide prediction server.

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.

RNA interference by osmotic lysis of pinosomes: liposome-independent transfection of siRNAs into mammalian cells.

Mechanisms of gene silencing by double-stranded RNA.

Human MicroRNA targets.

A pancreatic islet-specific microRNA regulates insulin secretion.

The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis.

Endogenous MHC class II processing of a viral nuclear antigen after autophagy.

Identification of microRNAs of the herpesvirus family.

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein.

Clustering and conservation patterns of human microRNAs.

The developmental miRNA profiles of zebrafish as determined by small RNA cloning.

Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development.

Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage.

Identification and characterization of small RNAs involved in RNA silencing.

Silencing of microRNAs in vivo with 'antagomirs'.

Identification of clustered microRNAs using an ab initio prediction method.

Identification of novel argonaute-associated proteins.

A novel class of small RNAs bind to MILI protein in mouse testes.

On the art of identifying effective and specific siRNAs.

A potential protein-RNA recognition event along the RISC-loading pathway from the structure of A. aeolicus Argonaute with externally bound siRNA.

Specific RNAi mediated gene knockdown in zebrafish cell lines.

Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs.

Cucumber mosaic virus-encoded 2b suppressor inhibits Arabidopsis Argonaute1 cleavage activity to counter plant defense.

Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia.

Specificity, duplex degradation and subcellular localization of antagomirs.

A mammalian microRNA expression atlas based on small RNA library sequencing.

Cellular cofactors affecting hepatitis C virus infection and replication.

Reactions of phosphate and phosphorothiolate diesters with nucleophiles: comparison of transition state structures.

Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline.

Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity.

Identification of microRNAs and other small regulatory RNAs using cDNA library sequencing.

Cloning of small RNA molecules.

The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members.

MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase.

MicroRNA-mediated down-regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg cells: a potential pathogenetic lesion in Hodgkin lymphomas.

Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype.

Structure of the guide-strand-containing argonaute silencing complex.

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs.

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.

A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways.

Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex.

DGCR8-dependent microRNA biogenesis is essential for skin development.

miRNA in situ hybridization in formaldehyde and EDC-fixed tissues.

The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo.

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.

The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation.

Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB.

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.

Absolute quantification of microRNAs by using a universal reference.

Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.

Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo.

Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I.

miRNAs in human cancer.

MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC.

Combined characterization of microRNA and mRNA profiles delineates early differentiation pathways of CD133+ and CD34+ hematopoietic stem and progenitor cells.

Deep sequencing of small RNAs specifically associated with Arabidopsis AGO1 and AGO4 uncovers new AGO functions.

Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.

MicroRNA sequence and expression analysis in breast tumors by deep sequencing.

Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma.

Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability.

RNA-ligase-dependent biases in miRNA representation in deep-sequenced small RNA cDNA libraries.

MicroRNA-24 regulates vascularity after myocardial infarction.

FOXO1 is an essential regulator of pluripotency in human embryonic stem cells.

Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.

New insights in the mechanism of microRNA-mediated target repression.

RNA targets of wild-type and mutant FET family proteins.

Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines.

Identification of RNA-protein interaction networks using PAR-CLIP.

The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines.