Nhat Huynh

Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions.

A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1.

Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1.

The SRSF1 linker induces semi-conservative ESE binding by cooperating with the RRMs.

Ivermectin reduces alcohol intake and preference in mice.

Multiday administration of ivermectin is effective in reducing alcohol intake in mice at doses shown to be safe in humans.

Oral delivery of ivermectin using a fast dissolving oral film: Implications for repurposing ivermectin as a pharmacotherapy for alcohol use disorder.

Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder.

Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice.

Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders.