Frederic Michon
Helsinki Institute of Life Science,
Institute of Biotechnology,
HiLIFE,
Helsinki Institute of Life Science, Institute of Biotechnology,
Institute of Biotechnology, HiLIFE
University of Helsinki
Frederic Michon is a Principal Investigator at the Institute of Biotechnology of the University of Helsinki, Finland. He received his PhD from the University of Grenoble I, France.
Dr. Michon is a classical developmental biologist, who is focusing on how to recapitulate in and ex vivo the cellular and molecular events occurring during organogenesis. This approach could have a tremendous influence on regenerative medicine. Currently, his lab is studying several aspects of stem cell biology and cell fate maintenance. Among the questions he is trying to find answers to, there are:
1. How does the stem cell signature emerge during embryogenesis?
2. Are stem cell and terminally differentiated cell capacities restricted by their microenvironment?
3. Can cells change fate upon an increase of plasticity, or a decrease of the microenvironment control?
4. Is the control from the surrounding decreasing with age, leading to a drastic modification of stem cell behavior?
The dynamic interest in topics within the biomedical scientific community.
PloS one Aug, 2009 | Pubmed ID: 19668345
Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs.
Developmental biology Apr, 2010 | Pubmed ID: 20102707
Tooth evolution and dental defects: from genetic regulation network to micro-RNA fine-tuning.
Birth defects research. Part A, Clinical and molecular teratology Aug, 2011 | Pubmed ID: 21591243
Expression of microRNAs in the stem cell niche of the adult mouse incisor.
PloS one , 2011 | Pubmed ID: 21931743
Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors.
Developmental cell Aug, 2012 | Pubmed ID: 22819339
Analysis of tissue interactions in ectodermal organ culture.
Methods in molecular biology (Clifton, N.J.) , 2013 | Pubmed ID: 23097120
Sox2 marks epithelial competence to generate teeth in mammals and reptiles.
Development (Cambridge, England) Apr, 2013 | Pubmed ID: 23462476
[The dental epithelial stem cells expressing Sox2 are involved in murine incisor renewal].
Medecine sciences : M/S Apr, 2013 | Pubmed ID: 23621924
Establishment of crown-root domain borders in mouse incisor.
Gene expression patterns : GEP Oct, 2013 | Pubmed ID: 23684768
Identification and validation of human papillomavirus encoded microRNAs.
PloS one , 2013 | Pubmed ID: 23936163
Lin-28 regulates oogenesis and muscle formation in Drosophila melanogaster.
PloS one , 2014 | Pubmed ID: 24963666
An Evo-Devo perspective on ever-growing teeth in mammals and dental stem cell maintenance.
Frontiers in physiology , 2014 | Pubmed ID: 25221518
Mesenchymal Wnt/β-Catenin Signaling Controls Epithelial Stem Cell Homeostasis in Teeth by Inhibiting the Antiapoptotic Effect of Fgf10.
Stem cells (Dayton, Ohio) May, 2015 | Pubmed ID: 25693510
Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal.
Development (Cambridge, England) 11, 2016 | Pubmed ID: 27660324
Epithelial Markers aSMA, Krt14, and Krt19 Unveil Elements of Murine Lacrimal Gland Morphogenesis and Maturation.
Frontiers in physiology , 2017 | Pubmed ID: 29033846
Plasticity within the niche ensures the maintenance of a stem cell population in the mouse incisor.
Development (Cambridge, England) 01, 2018 | Pubmed ID: 29180573
Bmi1+ Progenitor Cell Dynamics in Murine Cornea During Homeostasis and Wound Healing.
Stem cells (Dayton, Ohio) Apr, 2018 | Pubmed ID: 29282831
Ectodysplasin-A signaling is a key integrator in the lacrimal gland-cornea feedback loop.
Development (Cambridge, England) Jul, 2019 | Pubmed ID: 31221639
Unilateral zebrafish corneal injury induces bilateral cell plasticity supporting wound closure.
Scientific reports Jan, 2022 | Pubmed ID: 34997071
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