Department of Molecular Medicine and the Center on Aging
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NF-κB inhibition delays DNA damage-induced senescence and aging in mice.
The Journal of clinical investigation Jul, 2012 | Pubmed ID: 22706308
DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria.
Cell metabolism Sep, 2013 | Pubmed ID: 24011075
Investigating the role of DNA damage in tobacco smoking-induced spine degeneration.
The spine journal : official journal of the North American Spine Society Mar, 2014 | Pubmed ID: 24211096
Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death.
Scientific reports Jan, 2014 | Pubmed ID: 24406986
Comparison of mice with accelerated aging caused by distinct mechanisms.
Experimental gerontology Aug, 2015 | Pubmed ID: 25617508
NF-κB activation with aging: characterization and therapeutic inhibition.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25736771
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Aging cell Aug, 2015 | Pubmed ID: 25754370
In vivo detection and replication studies of α-anomeric lesions of 2'-deoxyribonucleosides.
Nucleic acids research Sep, 2015 | Pubmed ID: 26202973
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.
Aging cell 06, 2016 | Pubmed ID: 26711051
Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms.
The journals of gerontology. Series A, Biological sciences and medical sciences 11, 2016 | Pubmed ID: 27535964
Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses.
Analytical chemistry Oct, 2016 | Pubmed ID: 27560777
mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Aug, 2016 | Pubmed ID: 27572850
Molecular pathology endpoints useful for aging studies.
Ageing research reviews May, 2017 | Pubmed ID: 27721062
Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage.
Chemical research in toxicology 12, 2016 | Pubmed ID: 27989142
Quantitative Analysis of Cellular Senescence in Culture and In Vivo.
Current protocols in cytometry 01, 2017 | Pubmed ID: 28055114
Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism.
Aging cell 06, 2017 | Pubmed ID: 28229533
New agents that target senescent cells: the flavone, fisetin, and the BCL-X inhibitors, A1331852 and A1155463.
Aging 03, 2017 | Pubmed ID: 28273655
Systems biology guided by XCMS Online metabolomics.
Nature methods 04, 2017 | Pubmed ID: 28448069
ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration.
Spine Oct, 2017 | Pubmed ID: 28570296
Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2 Scripps Symposium on the Biology of Aging.
Aging cell 08, 2017 | Pubmed ID: 28585366
Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice.
PloS one , 2017 | Pubmed ID: 28640861
Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype.
Mechanisms of ageing and development 09, 2017 | Pubmed ID: 28830687
The Clinical Potential of Senolytic Drugs.
Journal of the American Geriatrics Society Oct, 2017 | Pubmed ID: 28869295
Identification of HSP90 inhibitors as a novel class of senolytics.
Nature communications 09, 2017 | Pubmed ID: 28871086
ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes.
Human mutation 02, 2018 | Pubmed ID: 29105242
Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans.
Aging cell 04, 2018 | Pubmed ID: 29290100
Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice.
The journals of gerontology. Series A, Biological sciences and medical sciences Jul, 2018 | Pubmed ID: 29415265
Senotherapeutics for healthy ageing.
Nature reviews. Drug discovery May, 2018 | Pubmed ID: 29651106
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.
Redox biology 07, 2018 | Pubmed ID: 29747066
ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation.
Free radical biology & medicine 08, 2018 | Pubmed ID: 29860127
Hsp90 inhibitors as senolytic drugs to extend healthy aging.
Cell cycle (Georgetown, Tex.) , 2018 | Pubmed ID: 29886783
Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.
PLoS biology 06, 2018 | Pubmed ID: 29889904
Neurodegeneration as the presenting symptom in 2 adults with xeroderma pigmentosum complementation group F.
Neurology. Genetics Jun, 2018 | Pubmed ID: 29892709
Nuclear Genomic Instability and Aging.
Annual review of biochemistry 06, 2018 | Pubmed ID: 29925262
Senolytics improve physical function and increase lifespan in old age.
Nature medicine 08, 2018 | Pubmed ID: 29988130
Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging.
Redox biology 09, 2018 | Pubmed ID: 30031267
Fisetin is a senotherapeutic that extends health and lifespan.
EBioMedicine Oct, 2018 | Pubmed ID: 30279143
Mouse Models of Accelerated Cellular Senescence.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 30474850
Methods to Quantify the NF-κB Pathway During Senescence.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 30474851
Measuring biological age in mice using differential mass spectrometry.
Aging Feb, 2019 | Pubmed ID: 30745468
Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jun, 2019 | Pubmed ID: 31170010
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