Department of Molecular Medicine and the Center on Aging
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NF-κB inhibition delays DNA damage-induced senescence and aging in mice.
The Journal of clinical investigation Jul, 2012 | Pubmed ID: 22706308
Lim mineralization protein 3 induces the osteogenic differentiation of human amniotic fluid stromal cells through Kruppel-like factor-4 downregulation and further bone-specific gene expression.
Journal of biomedicine & biotechnology , 2012 | Pubmed ID: 23097599
Pharmacologic IKK/NF-κB inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death.
Scientific reports Jan, 2014 | Pubmed ID: 24406986
Regulation of immune responses by extracellular vesicles.
Nature reviews. Immunology Mar, 2014 | Pubmed ID: 24566916
NF-κB activation with aging: characterization and therapeutic inhibition.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25736771
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Aging cell Aug, 2015 | Pubmed ID: 25754370
IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice.
European journal of immunology Nov, 2015 | Pubmed ID: 26260044
Arsenic Promotes NF-Κb-Mediated Fibroblast Dysfunction and Matrix Remodeling to Impair Muscle Stem Cell Function.
Stem cells (Dayton, Ohio) Mar, 2016 | Pubmed ID: 26537186
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.
Aging cell 06, 2016 | Pubmed ID: 26711051
Regulation of chronic inflammatory and immune processes by extracellular vesicles.
The Journal of clinical investigation Apr, 2016 | Pubmed ID: 27035808
Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms.
The journals of gerontology. Series A, Biological sciences and medical sciences 11, 2016 | Pubmed ID: 27535964
Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses.
Analytical chemistry Oct, 2016 | Pubmed ID: 27560777
mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Aug, 2016 | Pubmed ID: 27572850
Quantitative Analysis of Cellular Senescence in Culture and In Vivo.
Current protocols in cytometry 01, 2017 | Pubmed ID: 28055114
Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism.
Aging cell 06, 2017 | Pubmed ID: 28229533
Cellular senescence mediates fibrotic pulmonary disease.
Nature communications 02, 2017 | Pubmed ID: 28230051
New agents that target senescent cells: the flavone, fisetin, and the BCL-X inhibitors, A1331852 and A1155463.
Aging 03, 2017 | Pubmed ID: 28273655
Systems biology guided by XCMS Online metabolomics.
Nature methods 04, 2017 | Pubmed ID: 28448069
ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration.
Spine Oct, 2017 | Pubmed ID: 28570296
Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2 Scripps Symposium on the Biology of Aging.
Aging cell 08, 2017 | Pubmed ID: 28585366
Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice.
PloS one , 2017 | Pubmed ID: 28640861
Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes.
Scientific reports 07, 2017 | Pubmed ID: 28729721
Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype.
Mechanisms of ageing and development 09, 2017 | Pubmed ID: 28830687
The Clinical Potential of Senolytic Drugs.
Journal of the American Geriatrics Society Oct, 2017 | Pubmed ID: 28869295
Identification of HSP90 inhibitors as a novel class of senolytics.
Nature communications 09, 2017 | Pubmed ID: 28871086
Gene Delivery to Joints by Intra-Articular Injection.
Human gene therapy 01, 2018 | Pubmed ID: 29160173
Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans.
Aging cell 04, 2018 | Pubmed ID: 29290100
Arthritis Gene Therapy Approved in Korea.
The Journal of the American Academy of Orthopaedic Surgeons 01, 2018 | Pubmed ID: 29303924
Extracellular vesicles and aging.
Stem cell investigation , 2017 | Pubmed ID: 29359137
Senotherapeutics for healthy ageing.
Nature reviews. Drug discovery May, 2018 | Pubmed ID: 29651106
Arthritis gene therapy is becoming a reality.
Nature reviews. Rheumatology Jul, 2018 | Pubmed ID: 29743627
Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.
Redox biology 07, 2018 | Pubmed ID: 29747066
Treating Age-Related Diseases with Somatic Stem Cells.
Advances in experimental medicine and biology , 2018 | Pubmed ID: 29754173
Hsp90 inhibitors as senolytic drugs to extend healthy aging.
Cell cycle (Georgetown, Tex.) , 2018 | Pubmed ID: 29886783
Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.
PLoS biology 06, 2018 | Pubmed ID: 29889904
Nuclear Genomic Instability and Aging.
Annual review of biochemistry 06, 2018 | Pubmed ID: 29925262
Senolytics improve physical function and increase lifespan in old age.
Nature medicine 08, 2018 | Pubmed ID: 29988130
Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging.
Redox biology 09, 2018 | Pubmed ID: 30031267
Fisetin is a senotherapeutic that extends health and lifespan.
EBioMedicine Oct, 2018 | Pubmed ID: 30279143
Mouse Models of Accelerated Cellular Senescence.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 30474850
Methods to Quantify the NF-κB Pathway During Senescence.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 30474851
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
Journal of extracellular vesicles , 2018 | Pubmed ID: 30637094
Measuring biological age in mice using differential mass spectrometry.
Aging Feb, 2019 | Pubmed ID: 30745468
Murine models of accelerated aging and musculoskeletal disease.
Bone Aug, 2019 | Pubmed ID: 30844492
Signal Transduction, Ageing and Disease.
Sub-cellular biochemistry , 2019 | Pubmed ID: 30888655
Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jun, 2019 | Pubmed ID: 31170010
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