Department of Physiology and Cell Biology
I am a Research Assistant Professor in the Dept. of Physiology & Cell Biology at the University of Nevada, Reno (UNR), U.S.A, where I held a postdoctoral position from 2013-2017 after I received my PhD in Physiology from Dundalk Institute of Technology in 2013.
I actively engage in smooth muscle physiology research, teach research-led content in our physiology graduate and medical programmes, supervise undergraduate research students and serve on relevant committees. I became an Associate Fellow of the Higher Education Academy in 2017 and earned a postgraduate certificate (PG Cert) in 'Teaching & Learning In Higher Education' from University College Cork in 2018.
Since 2014 I have taught a range of modules in the UNR Cellular and Molecular Pharmacology & Physiology Graduate Programme and more recently in the School of Medicine Education Programme (MED) and the Physicians Assistant Studies (PAS) Programme. I conduct assessment for these modules using various modalities such as continuous assessment assignments, non-marked submissions and problem-solving based exams. I am also a tutor and mentor to international undergraduate exchange students. This role involves delivering tutorials, evaluating student understanding by classroom assessment techniques, providing academic counsel and advice for students and organizing the Annual International Student Research Symposium.
My research focuses on calcium signalling in smooth muscle, particularly in the urinary and gastrointestinal systems in order to find cellular targets for incontinence and motility disorders. During my postdoctoral fellowship I was awarded the Barcroft Early Career Medal, Royal Academy of Medicine in Ireland (2017) and produced an internationally recognized record of peer-reviewed publications in journals such as, J General Physiology, Nature Reviews Urology, Sci Sig, J Physiology, PNAS and Advances in Physiology Education, etc.
Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility.
Science signaling Sep, 2017 | Pubmed ID: 28928237
Ca signalling in mouse urethral smooth muscle in situ: role of Ca stores and Ca influx mechanisms.
The Journal of physiology 04, 2018 | Pubmed ID: 29383731
Laboratory practical to study the differential innervation pathways of urinary tract smooth muscle.
Advances in physiology education Jun, 2018 | Pubmed ID: 29676616
SOCE mediated by STIM and Orai is essential for pacemaker activity in the interstitial cells of Cajal in the gastrointestinal tract.
Science signaling 06, 2018 | Pubmed ID: 29895614
Tonic inhibition of murine proximal colon is due to nitrergic suppression of Ca signaling in interstitial cells of Cajal.
Scientific reports 03, 2019 | Pubmed ID: 30867452
Active peer-mentored learning can improve student understanding of physiological concepts in an undergraduate journal club.
Advances in physiology education Sep, 2019 | Pubmed ID: 31305151
Pacemaker function and neural responsiveness of subserosal interstitial cells of Cajal in the mouse colon.
The Journal of physiology 02, 2020 | Pubmed ID: 31811726
Contribution of Ca1.2 Ca channels and store-operated Ca entry to pig urethral smooth muscle contraction.
American journal of physiology. Renal physiology 02, 2020 | Pubmed ID: 31904286
Identification and classification of interstitial cells in the mouse renal pelvis.
The Journal of physiology 08, 2020 | Pubmed ID: 32415739
Excitatory cholinergic responses in mouse colon intramuscular interstitial cells of Cajal are due to enhanced Ca release via M receptor activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 08, 2020 | Pubmed ID: 32539213
TRPML1 channels initiate Ca sparks in vascular smooth muscle cells.
Science signaling 06, 2020 | Pubmed ID: 32576680
A novel intramuscular Interstitial Cell of Cajal is a candidate for generating pacemaker activity in the mouse internal anal sphincter.
Scientific reports 06, 2020 | Pubmed ID: 32587396
The intracellular Ca release channel TRPML1 regulates lower urinary tract smooth muscle contractility.
Proceedings of the National Academy of Sciences of the United States of America 12, 2020 | Pubmed ID: 33199609
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