Division of Neuroscience and Experimental Psychology,
School of Biological Sciences,
Faculty of Biology,
Medicine and Health,
Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health
David Brough has not added Biography.
If you are David Brough and would like to personalize this page please email our Author Liaison for assistance.
Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production.
The Journal of biological chemistry Feb, 2002 | Pubmed ID: 11706016
Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism.
Molecular and cellular neurosciences Feb, 2002 | Pubmed ID: 11860279
Extracellular ATP and P2X7 receptors in neurodegeneration.
European journal of pharmacology Jul, 2002 | Pubmed ID: 12151017
Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Mar, 2003 | Pubmed ID: 12621313
Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2003 | Pubmed ID: 12626557
Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta.
Journal of neurochemistry Jun, 2003 | Pubmed ID: 12787061
The structural integrity of the endoplasmic reticulum, and its possible regulation by inositol 1,3,4,5-tetrakisphosphate.
Cell calcium Aug, 2005 | Pubmed ID: 16023721
Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death.
Journal of cell science Mar, 2007 | Pubmed ID: 17284521
Mechanisms of regulation for interleukin-1beta in neurodegenerative disease.
Neuropharmacology Jun, 2007 | Pubmed ID: 17428507
A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat.
Neuropharmacology Oct, 2007 | Pubmed ID: 17845807
Neuronal injury induces the release of pro-interleukin-1beta from activated microglia in vitro.
Brain research Oct, 2008 | Pubmed ID: 18722361
The dynamics and mechanisms of interleukin-1alpha and beta nuclear import.
Traffic (Copenhagen, Denmark) Jan, 2009 | Pubmed ID: 18939951
Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc.
European journal of immunology Feb, 2009 | Pubmed ID: 19130485
Nuclear retention of IL-1 alpha by necrotic cells: a mechanism to dampen sterile inflammation.
European journal of immunology Nov, 2009 | Pubmed ID: 19839011
Regulation of interleukin-1 in acute brain injury.
Trends in pharmacological sciences Oct, 2011 | Pubmed ID: 21788085
Understanding the mechanism of IL-1β secretion.
Cytokine & growth factor reviews Aug, 2011 | Pubmed ID: 22019906
Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing.
Nature chemical biology Dec, 2011 | Pubmed ID: 22020553
Two zinc uptake systems contribute to the full virulence of Listeria monocytogenes during growth in vitro and in vivo.
Infection and immunity Jan, 2012 | Pubmed ID: 22025520
Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.
European journal of immunology Mar, 2012 | Pubmed ID: 22105559
Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues.
Journal of neuroinflammation Dec, 2011 | Pubmed ID: 22206506
Obese mice exhibit an altered behavioural and inflammatory response to lipopolysaccharide.
Disease models & mechanisms Sep, 2012 | Pubmed ID: 22328591
Inhibition of calpain blocks the phagosomal escape of Listeria monocytogenes.
PloS one , 2012 | Pubmed ID: 22563421
Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology.
Disease models & mechanisms Nov, 2012 | Pubmed ID: 22679224
NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation after Injury.
Frontiers in immunology , 2012 | Pubmed ID: 23024646
Deubiquitinases regulate the activity of caspase-1 and interleukin-1β secretion via assembly of the inflammasome.
The Journal of biological chemistry Jan, 2013 | Pubmed ID: 23209292
Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices.
Glia May, 2013 | Pubmed ID: 23404620
Acidosis drives damage-associated molecular pattern (DAMP)-induced interleukin-1 secretion via a caspase-1-independent pathway.
The Journal of biological chemistry Oct, 2013 | Pubmed ID: 24022484
The role of inflammation and interleukin-1 in acute cerebrovascular disease.
Journal of inflammation research Aug, 2013 | Pubmed ID: 24062616
Release of interleukin-1α or interleukin-1β depends on mechanism of cell death.
The Journal of biological chemistry Jun, 2014 | Pubmed ID: 24790078
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.
Nature immunology Aug, 2014 | Pubmed ID: 24952504
Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome.
The Journal of biological chemistry Dec, 2014 | Pubmed ID: 25371210
Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2015 | Pubmed ID: 25552542
AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2015 | Pubmed ID: 25775556
Interleukin-1α and brain inflammation.
IUBMB life May, 2015 | Pubmed ID: 25906979
P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages.
Cytokine Aug, 2015 | Pubmed ID: 26068648
Interleukin-1 as a pharmacological target in acute brain injury.
Experimental physiology Dec, 2015 | Pubmed ID: 26096539
Acid-dependent Interleukin-1 (IL-1) Cleavage Limits Available Pro-IL-1β for Caspase-1 Cleavage.
The Journal of biological chemistry Oct, 2015 | Pubmed ID: 26324708
Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways.
European journal of immunology Oct, 2015 | Pubmed ID: 26332156
Inhibiting the Inflammasome: A Chemical Perspective.
Journal of medicinal chemistry Mar, 2016 | Pubmed ID: 26422006
Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.
Frontiers in immunology , 2015 | Pubmed ID: 26635802
Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging.
Methods in molecular biology (Clifton, N.J.) , 2016 | Pubmed ID: 27221482
Novel perspectives on non-canonical inflammasome activation.
ImmunoTargets and therapy , 2015 | Pubmed ID: 27471719
Inflammasomes link vascular disease with neuroinflammation and brain disorders.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 10, 2016 | Pubmed ID: 27486046
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.
Nature communications , 2016 | Pubmed ID: 27509875
P2X7 receptor-dependent tuning of gut epithelial responses to infection.
Immunology and cell biology 02, 2017 | Pubmed ID: 27559003
Inflammasomes as therapeutic targets for Alzheimer's disease.
Brain pathology (Zurich, Switzerland) 03, 2017 | Pubmed ID: 28009077
Unconventional Pathways of Secretion Contribute to Inflammation.
International journal of molecular sciences Jan, 2017 | Pubmed ID: 28067797
Salmonella typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and can occur in the absence of pyroptosis.
Scientific reports 07, 2017 | Pubmed ID: 28761045
An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β.
Journal of cell science Oct, 2017 | Pubmed ID: 28871048
Boron-Based Inhibitors of the NLRP3 Inflammasome.
Cell chemical biology Nov, 2017 | Pubmed ID: 28943355
Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI.
Journal of neuroimaging : official journal of the American Society of Neuroimaging Mar, 2018 | Pubmed ID: 29064155
CRISPR/Cas9 mediated mutation of mouse IL-1α nuclear localisation sequence abolishes expression.
Scientific reports 12, 2017 | Pubmed ID: 29213066
Microglial Priming as Trained Immunity in the Brain.
Neuroscience 05, 2019 | Pubmed ID: 29292078
Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome.
ChemMedChem 02, 2018 | Pubmed ID: 29331080
Synthesis and antibacterial activities of enamine derivatives of dehydroacetic acid.
Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents , 2018 | Pubmed ID: 29527108
Redefining the ancestral origins of the interleukin-1 superfamily.
Nature communications 03, 2018 | Pubmed ID: 29559685
Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.
Scientific reports Apr, 2018 | Pubmed ID: 29618797
Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria.
Proceedings of the National Academy of Sciences of the United States of America 07, 2018 | Pubmed ID: 29954866
Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery?
SLAS discovery : advancing life sciences R & D Dec, 2018 | Pubmed ID: 29969573
USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation.
EMBO reports 10, 2018 | Pubmed ID: 30206189
Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming.
Proceedings of the National Academy of Sciences of the United States of America 10, 2018 | Pubmed ID: 30232264
Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 via Metabolic Reprogramming.
ACS nano Dec, 2018 | Pubmed ID: 30444603
Improving the Gene Ontology Resource to Facilitate More Informative Analysis and Interpretation of Alzheimer's Disease Data.
Genes Nov, 2018 | Pubmed ID: 30501127
The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.
The Journal of biological chemistry May, 2019 | Pubmed ID: 30940725
Cathelicidin is a "fire alarm", generating protective NLRP3-dependent airway epithelial cell inflammatory responses during infection with Pseudomonas aeruginosa.
PLoS pathogens Apr, 2019 | Pubmed ID: 30978238
Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome.
Stroke May, 2019 | Pubmed ID: 31009361
JoVE 소개
Copyright © 2024 MyJoVE Corporation. 판권 소유