Nicole is a Senior Associate Director for Research Programs at The Michael J. Fox Foundation for Parkinson's Research. She earned her BA in Biology from Kalamazoo College in Kalamazoo, Michigan and received her PhD in Neuroscience from Michigan State University. Her thesis research focused on characterizing and improving viral vector-mediated gene therapy in the aged brain for use in age-related neurodegenerative diseases like Parkinson's disease.
Nicole joined The Michael J. Fox Foundation (MJFF) in 2016 where she now serves as the strategic lead for the Preclinical Tools and Models Program. Nicole stays closely linked in with the Parkinson’s research community to maintain a current view of the PD research landscape and ensure that MJFF research priorities reflect and best serve the ultimate needs of PD research and patient community. This includes regularly meeting with academic and industry researchers at Foundation-hosted workshops and conferences as well as traveling to Parkinson’s/neuroscience congresses and symposia around the world. She currently supports the Foundation's Preclinical Tools and Preclinical Models portfolios, working with academic groups, contract research organizations, and pharmaceutical partners to facilitate the Foundation's efforts to generate, characterize, and widely distribute novel, research-enabling tools for the PD drug development and fundamental research communities.
Development of phospho-specific Rab protein antibodies to monitor activity of the LRRK2 Parkinson's disease kinase.
The Biochemical journal 01, 2018 | Pubmed ID: 29127256
Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents.
Journal of Parkinson's disease , 2018 | Pubmed ID: 29400668
The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
The Biochemical journal 06, 2018 | Pubmed ID: 29743203
Joseph R. Patterson1,
Nicole K. Polinski2,
Megan F. Duffy1,3,
Christopher J. Kemp1,
Kelvin C. Luk4,
Laura A. Volpicelli-Daley5,
Nicholas M. Kanaan1,
Caryl E. Sortwell1,3,6
1Department of Translational Science and Molecular Medicine, Michigan State University,
2, The Michael J. Fox Foundation for Parkinson's Research,
3Neuroscience Program, Michigan State University,
4Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine,
5Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham,
6, Mercy Health Hauenstein Neuroscience Medical Center
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