MOE Key Laboratory of Bioinformatics,
Center for Synthetic and Systems Biology,
School of Life Sciences,
MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences
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Kinetic and mechanistic studies of p38α MAP kinase phosphorylation by MKK6.
The FEBS journal Mar, 2019 | Pubmed ID: 30663248
Reductive glutaraldehydation of amine groups for identification of protein N-termini.
Journal of proteome research Sep, 2008 | Pubmed ID: 18636758
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.
Cell Feb, 2011 | Pubmed ID: 21255825
Expanding cofactor repertoire of protein lysine methyltransferase for substrate labeling.
ACS chemical biology Jul, 2011 | Pubmed ID: 21495674
Labeling substrates of protein arginine methyltransferase with engineered enzymes and matched S-adenosyl-L-methionine analogues.
Journal of the American Chemical Society May, 2011 | Pubmed ID: 21539310
Reproducible enrichment of extracellular heat shock proteins from blood serum using monomeric avidin.
Bioorganic & medicinal chemistry letters Jul, 2011 | Pubmed ID: 21689931
Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein.
Cell research Feb, 2012 | Pubmed ID: 22310240
Structural basis of ultraviolet-B perception by UVR8.
Nature Feb, 2012 | Pubmed ID: 22388820
Function and molecular mechanism of acetylation in autophagy regulation.
Science (New York, N.Y.) Apr, 2012 | Pubmed ID: 22539722
Se-adenosyl-L-selenomethionine cofactor analogue as a reporter of protein methylation.
Journal of the American Chemical Society Sep, 2012 | Pubmed ID: 22917021
Development of the Fc-III Tagged Protein Expression System for Protein Purification and Detection.
PloS one , 2012 | Pubmed ID: 22952929
Profiling genome-wide chromatin methylation with engineered posttranslation apparatus within living cells.
Journal of the American Chemical Society Jan, 2013 | Pubmed ID: 23244065
c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor.
Molecular cell Feb, 2013 | Pubmed ID: 23290524
Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM and general features of the assembly process.
Nucleic acids research Feb, 2013 | Pubmed ID: 23293003
L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia.
Cell research May, 2013 | Pubmed ID: 23337585
A proposed role for glutamine in cancer cell growth through acid resistance.
Cell research Jan, 2013 | Pubmed ID: 23357849
The Arabidopsis F-box protein CORONATINE INSENSITIVE1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway.
The Plant cell Feb, 2013 | Pubmed ID: 23386265
Flagellar regeneration requires cytoplasmic microtubule depolymerization and kinesin-13.
Journal of cell science Mar, 2013 | Pubmed ID: 23418346
Oxidative stress induces monocyte necrosis with enrichment of cell-bound albumin and overexpression of endoplasmic reticulum and mitochondrial chaperones.
PloS one , 2013 | Pubmed ID: 23555724
Quantitative analysis of differentially expressed saliva proteins in human immunodeficiency virus type 1 (HIV-1) infected individuals.
Analytica chimica acta Apr, 2013 | Pubmed ID: 23567117
Effects of the Fc-III tag on activity and stability of green fluorescent protein and human muscle creatine kinase.
Protein science : a publication of the Protein Society Jul, 2013 | Pubmed ID: 23661339
Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2013 | Pubmed ID: 23690600
Cryo-EM structures of the late-stage assembly intermediates of the bacterial 50S ribosomal subunit.
Nucleic acids research Aug, 2013 | Pubmed ID: 23700310
Azacytidine induces necrosis of multiple myeloma cells through oxidative stress.
Proteome science Jun, 2013 | Pubmed ID: 23764212
Crystal structure of NLRC4 reveals its autoinhibition mechanism.
Science (New York, N.Y.) Jul, 2013 | Pubmed ID: 23765277
Structural basis for the regulation of maternal embryonic leucine zipper kinase.
PloS one , 2013 | Pubmed ID: 23922895
Deacetylase Rpd3 facilitates checkpoint adaptation by preventing Rad53 overactivation.
Molecular and cellular biology Nov, 2013 | Pubmed ID: 23979600
Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2013 | Pubmed ID: 24082136
Overexpression of CD38 decreases cellular NAD levels and alters the expression of proteins involved in energy metabolism and antioxidant defense.
Journal of proteome research Feb, 2014 | Pubmed ID: 24295520
Profiling substrates of protein arginine N-methyltransferase 3 with S-adenosyl-L-methionine analogues.
ACS chemical biology Feb, 2014 | Pubmed ID: 24320160
The gain of hydrogen peroxide resistance benefits growth fitness in mycobacteria under stress.
Protein & cell Mar, 2014 | Pubmed ID: 24563215
Structural insights into the assembly of the 30S ribosomal subunit in vivo: functional role of S5 and location of the 17S rRNA precursor sequence.
Protein & cell May, 2014 | Pubmed ID: 24671761
Systematic analysis of reactivities and fragmentation of glutathione and its isomer GluCysGly.
The journal of physical chemistry. A Sep, 2014 | Pubmed ID: 24734962
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
Nature communications May, 2014 | Pubmed ID: 24821572
Substrate profiling of glutathione S-transferase with engineered enzymes and matched glutathione analogues.
Angewandte Chemie (International ed. in English) Jul, 2014 | Pubmed ID: 24889263
Down-regulation of Ras-related protein Rab 5C-dependent endocytosis and glycolysis in cisplatin-resistant ovarian cancer cell lines.
Molecular & cellular proteomics : MCP Nov, 2014 | Pubmed ID: 25096996
Rab8a-AS160-MSS4 Regulatory Circuit Controls Lipid Droplet Fusion and Growth.
Developmental cell Aug, 2014 | Pubmed ID: 25158853
FLA8/KIF3B phosphorylation regulates kinesin-II interaction with IFT-B to control IFT entry and turnaround.
Developmental cell Sep, 2014 | Pubmed ID: 25175706
Site-specific in situ growth of a cyclized protein-polymer conjugate with improved stability and tumor retention.
Biomaterials Apr, 2015 | Pubmed ID: 25682156
Phosphorylation of Atg31 is required for autophagy.
Protein & cell Apr, 2015 | Pubmed ID: 25773276
Role for Protein Kinase A in the Neurospora Circadian Clock by Regulating White Collar-Independent frequency Transcription through Phosphorylation of RCM-1.
Molecular and cellular biology Jun, 2015 | Pubmed ID: 25848091
Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming.
Cell stem cell Jun, 2015 | Pubmed ID: 25936917
Proteomic Analysis of Drug-Resistant Mycobacteria: Co-Evolution of Copper and INH Resistance.
PloS one , 2015 | Pubmed ID: 26035302
Analysis of phosphorylation sites on autophagy proteins.
Protein & cell Sep, 2015 | Pubmed ID: 26081468
Site-selective in situ growth of fluorescent polymer-antibody conjugates with enhanced antigen detection by signal amplification.
Biomaterials Sep, 2015 | Pubmed ID: 26102329
The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.
Nature Aug, 2015 | Pubmed ID: 26147081
Gefitinib upregulates death receptor 5 expression to mediate rmhTRAIL-induced apoptosis in Gefitinib-sensitive NSCLC cell line.
OncoTargets and therapy , 2015 | Pubmed ID: 26170696
Functional Characterization of Sirtuin-like Protein in Mycobacterium smegmatis.
Journal of proteome research Nov, 2015 | Pubmed ID: 26375486
Benzophenone and its analogs bind to human glyoxalase 1.
Bioorganic & medicinal chemistry letters Nov, 2015 | Pubmed ID: 26420066
Effects and mechanism of arsenic trioxide in combination with rmhTRAIL in multiple myeloma.
Experimental hematology Feb, 2016 | Pubmed ID: 26505911
Development of a Clickable Probe for Profiling of Protein Glutathionylation in the Central Cellular Metabolism of E. coli and Drosophila.
Chemistry & biology Nov, 2015 | Pubmed ID: 26526100
Disruption of microtubules in plants suppresses macroautophagy and triggers starch excess-associated chloroplast autophagy.
Autophagy , 2015 | Pubmed ID: 26566764
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing.
eLife Nov, 2015 | Pubmed ID: 26575292
Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease.
Protein & cell Feb, 2016 | Pubmed ID: 26746706
The BAH domain of BAHD1 is a histone H3K27me3 reader.
Protein & cell Mar, 2016 | Pubmed ID: 26850261
Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression.
Protein & cell Apr, 2016 | Pubmed ID: 26893145
The Protease Locus of Francisella tularensis LVS Is Required for Stress Tolerance and Infection in the Mammalian Host.
Infection and immunity May, 2016 | Pubmed ID: 26902724
Silencing PRDX3 Inhibits Growth and Promotes Invasion and Extracellular Matrix Degradation in Hepatocellular Carcinoma Cells.
Journal of proteome research 05, 2016 | Pubmed ID: 26983019
Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein and has multiple functions.
Biochimica et biophysica acta Jul, 2016 | Pubmed ID: 27033522
Downregulation of HSP60 disrupts mitochondrial proteostasis to promote tumorigenesis and progression in clear cell renal cell carcinoma.
Oncotarget Jun, 2016 | Pubmed ID: 27246978
Establishment of local searching methods for orbitrap-based high throughput metabolomics analysis.
Talanta Aug, 2016 | Pubmed ID: 27260449
Proteomic analysis of mTOR inhibition-mediated phosphorylation changes in ribosomal proteins and eukaryotic translation initiation factors.
Protein & cell 07, 2016 | Pubmed ID: 27278278
Serum markers of pre-eclampsia identified on proteomics.
The journal of obstetrics and gynaecology research Sep, 2016 | Pubmed ID: 27279411
Target and resistance-related proteins of recombinant mutant human tumor necrosis factor-related apoptosis-inducing ligand on myeloma cell lines.
Biomedical reports Jun, 2016 | Pubmed ID: 27284413
Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length.
Nature communications Jun, 2016 | Pubmed ID: 27306797
Downregulation of vimentin expression increased drug resistance in ovarian cancer cells.
Oncotarget Jul, 2016 | Pubmed ID: 27322682
Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway.
Scientific reports 06, 2016 | Pubmed ID: 27325206
aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicus but is Dispensable for the Growth of the Organism.
Molecular & cellular proteomics : MCP 09, 2016 | Pubmed ID: 27329856
Development of the Double Cyclic Peptide Ligand for Antibody Purification and Protein Detection.
Bioconjugate chemistry 07, 2016 | Pubmed ID: 27362542
Identification of common and differential mechanisms of glomerulus and tubule senescence in 24-month-old rats by quantitative LC-MS/MS.
Proteomics Oct, 2016 | Pubmed ID: 27452873
Hydrogen peroxide mediated mitochondrial UNG1-PRDX3 interaction and UNG1 degradation.
Free radical biology & medicine 10, 2016 | Pubmed ID: 27480846
Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility.
Nature genetics 12, 2016 | Pubmed ID: 27798626
Identification and validation of differentially expressed proteins in epithelial ovarian cancers using quantitative proteomics.
Oncotarget Dec, 2016 | Pubmed ID: 27825122
Proteomic Analysis of eIF5B Silencing-Modulated Proteostasis.
PloS one , 2016 | Pubmed ID: 27959964
ShHTL7 is a non-canonical receptor for strigolactones in root parasitic weeds.
Cell research 06, 2017 | Pubmed ID: 28059066
Chemical Synthesis of Diubiquitin-Based Photoaffinity Probes for Selectively Profiling Ubiquitin-Binding Proteins.
Angewandte Chemie (International ed. in English) 03, 2017 | Pubmed ID: 28145610
HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage.
The Journal of clinical investigation Apr, 2017 | Pubmed ID: 28287402
Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation.
Nature neuroscience May, 2017 | Pubmed ID: 28346453
Fasting-induced hormonal regulation of lysosomal function.
Cell research Jun, 2017 | Pubmed ID: 28374748
Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.
Scientific reports 04, 2017 | Pubmed ID: 28397817
Formation of a Snf1-Mec1-Atg1 Module on Mitochondria Governs Energy Deprivation-Induced Autophagy by Regulating Mitochondrial Respiration.
Developmental cell 04, 2017 | Pubmed ID: 28399401
Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry.
Cell 04, 2017 | Pubmed ID: 28431250
Comparative Proteomics Reveals Timely Transport into Cilia of Regulators or Effectors as a Mechanism Underlying Ciliary Disassembly.
Journal of proteome research Jul, 2017 | Pubmed ID: 28534617
Comprehensive Myocardial Proteogenomics Profiling Reveals C/EBPα as the Key Factor in the Lipid Storage of ARVC.
Journal of proteome research 08, 2017 | Pubmed ID: 28665611
Quasi-Dual-Packed-Kerneled Au (2,4-DMBT) Nanoclusters and the Influence of Kernel Packing on the Electrochemical Gap.
Angewandte Chemie (International ed. in English) 10, 2017 | Pubmed ID: 28809460
Emergence of two distinct subpopulations from Klebsiella pneumoniae grown in the stimulated microgravity environment.
Future microbiology 09, 2017 | Pubmed ID: 28816520
Simple β-lactones are potent irreversible antagonists for strigolactone receptors.
Cell research 12, 2017 | Pubmed ID: 28820177
Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity.
Archives of toxicology Jan, 2018 | Pubmed ID: 28871336
MtHsp70-CLIC1-pulsed dendritic cells enhance the immune response against ovarian cancer.
Biochemical and biophysical research communications 12, 2017 | Pubmed ID: 29061300
Quantitative proteomic analysis of deciduous molars during cap to bell transition in miniature pig.
Journal of proteomics 02, 2018 | Pubmed ID: 29129749
ISG15 silencing increases cisplatin resistance via activating p53-mediated cell DNA repair.
Oncotarget Dec, 2017 | Pubmed ID: 29296177
ROS-Mediated 15-Hydroxyprostaglandin Dehydrogenase Degradation via Cysteine Oxidation Promotes NAD-Mediated Epithelial-Mesenchymal Transition.
Cell chemical biology 03, 2018 | Pubmed ID: 29307841
Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis.
Journal of proteome research 03, 2018 | Pubmed ID: 29356545
PP5 (PPP5C) is a phosphatase of Dvl2.
Scientific reports 02, 2018 | Pubmed ID: 29426949
GATA3 acetylation at K119 by CBP inhibits cell migration and invasion in lung adenocarcinoma.
Biochemical and biophysical research communications 03, 2018 | Pubmed ID: 29453984
The Fourth Alloying Mode by Way of Anti-Galvanic Reaction.
Angewandte Chemie (International ed. in English) Apr, 2018 | Pubmed ID: 29468789
Enantioselective and diastereoselective azo-coupling/iminium-cyclizations: a unified strategy for the total syntheses of (-)-psychotriasine and (+)-pestalazine B.
Chemical science Jun, 2015 | Pubmed ID: 29511522
The contribution of chronic intermittent hypoxia to OSAHS: From the perspective of serum extracellular microvesicle proteins.
Metabolism: clinical and experimental Aug, 2018 | Pubmed ID: 29522771
De novo annotation and characterization of the translatome with ribosome profiling data.
Nucleic acids research 06, 2018 | Pubmed ID: 29538776
Injury Activates Ca/Calmodulin-Dependent Phosphorylation of JAV1-JAZ8-WRKY51 Complex for Jasmonate Biosynthesis.
Molecular cell 04, 2018 | Pubmed ID: 29625034
Is the kernel-staples match a key-lock match?
Chemical science Mar, 2018 | Pubmed ID: 29732119
Glutaredoxin Deletion Shortens Chronological Life Span in Saccharomyces cerevisiae via ROS-Mediated Ras/PKA Activation.
Journal of proteome research 07, 2018 | Pubmed ID: 29790350
Structural basis of ubiquitin modification by the Legionella effector SdeA.
Nature 05, 2018 | Pubmed ID: 29795342
Expression and prognostic value of CLIC1 in epithelial ovarian cancer.
Experimental and therapeutic medicine Jun, 2018 | Pubmed ID: 29805518
Circulating immune complexome analysis identified anti-tubulin-α-1c as an inflammation associated autoantibody with promising diagnostic value for Behcet's Disease.
PloS one , 2018 | Pubmed ID: 29902281
Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition.
Molecular & cellular proteomics : MCP 10, 2018 | Pubmed ID: 29980616
A Silver Nanocluster Containing Interstitial Sulfur and Unprecedented Chemical Bonds.
Angewandte Chemie (International ed. in English) Aug, 2018 | Pubmed ID: 30010231
SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis.
Journal of proteome research 09, 2018 | Pubmed ID: 30095923
Multiple domains of bacterial and human Lon proteases define substrate selectivity.
Emerging microbes & infections Aug, 2018 | Pubmed ID: 30120231
Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase.
PLoS pathogens 08, 2018 | Pubmed ID: 30157283
Myeloid-derived suppressor cells inhibit T cell activation through nitrating LCK in mouse cancers.
Proceedings of the National Academy of Sciences of the United States of America 10, 2018 | Pubmed ID: 30232256
The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.
Cell Nov, 2018 | Pubmed ID: 30270039
Kernel Homology in Gold Nanoclusters.
Angewandte Chemie (International ed. in English) Nov, 2018 | Pubmed ID: 30290044
Isotope tracing assisted metabolic profiling: Application to understanding HSP60 silencing mediated tumor progression.
Analytica chimica acta Jan, 2019 | Pubmed ID: 30567669
Geminiviral V2 Protein Suppresses Transcriptional Gene Silencing through Interaction with AGO4.
Journal of virology Mar, 2019 | Pubmed ID: 30626668
Fcc versus Non-fcc Structural Isomerism of Gold Nanoparticles with Kernel Atom Packing Dependent Photoluminescence.
Angewandte Chemie (International ed. in English) Mar, 2019 | Pubmed ID: 30719808
Cysteine-Aminoethylation-Assisted Chemical Ubiquitination of Recombinant Histones.
Journal of the American Chemical Society Feb, 2019 | Pubmed ID: 30758956
Loss of BAP1 Results in Growth Inhibition and Enhances Mesenchymal-Epithelial Transition in Kidney Tumor Cells.
Molecular & cellular proteomics : MCP Jul, 2019 | Pubmed ID: 30992312
Development of a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF) for targeted antibody blocking.
Chemical science Mar, 2019 | Pubmed ID: 30996912
HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells.
Redox biology Jun, 2019 | Pubmed ID: 31112866
OLFR734 Mediates Glucose Metabolism as a Receptor of Asprosin.
Cell metabolism Aug, 2019 | Pubmed ID: 31230984
Chemical Proteomic Profiling of Bromodomains Enables the Wide-Spectrum Evaluation of Bromodomain Inhibitors in Living Cells.
Journal of the American Chemical Society Jul, 2019 | Pubmed ID: 31246451
DNA Damage Activates TGF-β Signaling via ATM-c-Cbl-Mediated Stabilization of the Type II Receptor TβRII.
Cell reports Jul, 2019 | Pubmed ID: 31315051
Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders.
Journal of medicinal chemistry Aug, 2019 | Pubmed ID: 31330105
Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation.
Nature cell biology Aug, 2019 | Pubmed ID: 31371827
HtrA-mediated selective degradation of DNA uptake apparatus accelerates termination of pneumococcal transformation.
Molecular microbiology Aug, 2019 | Pubmed ID: 31396996
HSP60-regulated Mitochondrial Proteostasis and Protein Translation Promote Tumor Growth of Ovarian Cancer.
Scientific reports Sep, 2019 | Pubmed ID: 31477750
1Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University,
2Mass Spectrometry Core Facility, School of Life Sciences, Westlake University,
3MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University
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