Department of Infectious Diseases
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Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis.
The Journal of biological chemistry Nov, 1996 | Pubmed ID: 8910376
A conserved histidine is essential for glycerolipid acyltransferase catalysis.
Journal of bacteriology Mar, 1998 | Pubmed ID: 9515909
A missense mutation accounts for the defect in the glycerol-3-phosphate acyltransferase expressed in the plsB26 mutant.
Journal of bacteriology Mar, 1999 | Pubmed ID: 10074094
beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis.
Journal of bacteriology Jan, 2000 | Pubmed ID: 10629181
Response of Bacillus subtilis to cerulenin and acquisition of resistance.
Journal of bacteriology May, 2001 | Pubmed ID: 11325930
The licC gene of Streptococcus pneumoniae encodes a CTP:phosphocholine cytidylyltransferase.
Journal of bacteriology Aug, 2001 | Pubmed ID: 11466299
Structure and mechanism of CTP:phosphocholine cytidylyltransferase (LicC) from Streptococcus pneumoniae.
The Journal of biological chemistry Feb, 2002 | Pubmed ID: 11706035
Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion.
The EMBO journal Feb, 2002 | Pubmed ID: 11823414
The solution structure of acyl carrier protein from Mycobacterium tuberculosis.
The Journal of biological chemistry May, 2002 | Pubmed ID: 11825906
The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli.
The Journal of biological chemistry May, 2002 | Pubmed ID: 11859088
Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport.
The EMBO journal Apr, 2002 | Pubmed ID: 11927540
A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli.
Antimicrobial agents and chemotherapy May, 2002 | Pubmed ID: 11959552
Forty years of bacterial fatty acid synthesis.
Biochemical and biophysical research communications Apr, 2002 | Pubmed ID: 11969206
The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes.
Gene May, 2002 | Pubmed ID: 12095677
A new mechanism for anaerobic unsaturated fatty acid formation in Streptococcus pneumoniae.
The Journal of biological chemistry Nov, 2002 | Pubmed ID: 12237320
The Claisen condensation in biology.
Natural product reports Oct, 2002 | Pubmed ID: 12430724
Characterization of Streptococcus pneumoniae enoyl-(acyl-carrier protein) reductase (FabK).
The Biochemical journal Mar, 2003 | Pubmed ID: 12487627
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
Journal of lipid research Jan, 2003 | Pubmed ID: 12518017
Role of feedback regulation of pantothenate kinase (CoaA) in control of coenzyme A levels in Escherichia coli.
Journal of bacteriology Jun, 2003 | Pubmed ID: 12754240
Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
The Journal of biological chemistry Sep, 2003 | Pubmed ID: 12826668
The 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae.
Journal of bacteriology Jul, 2003 | Pubmed ID: 12837788
Key residues responsible for acyl carrier protein and beta-ketoacyl-acyl carrier protein reductase (FabG) interaction.
The Journal of biological chemistry Dec, 2003 | Pubmed ID: 14527946
Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG.
Structure (London, England : 1993) Mar, 2004 | Pubmed ID: 15016358
Fatty acid biosynthesis as a target for novel antibacterials.
Current opinion in investigational drugs (London, England : 2000) Feb, 2004 | Pubmed ID: 15043388
Product diversity and regulation of type II fatty acid synthases.
Biochemistry and cell biology = Biochimie et biologie cellulaire Feb, 2004 | Pubmed ID: 15052334
Evaluation of epigallocatechin gallate and related plant polyphenols as inhibitors of the FabG and FabI reductases of bacterial type II fatty-acid synthase.
The Journal of biological chemistry Jul, 2004 | Pubmed ID: 15133034
The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites.
The Journal of biological chemistry Aug, 2004 | Pubmed ID: 15136582
Prediction of mechanisms of action of antibacterial compounds by gene expression profiling.
Antimicrobial agents and chemotherapy Aug, 2004 | Pubmed ID: 15273089
Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites.
The Journal of biological chemistry Dec, 2004 | Pubmed ID: 15459190
A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A.
The Journal of biological chemistry Feb, 2005 | Pubmed ID: 15548531
The reductase steps of the type II fatty acid synthase as antimicrobial targets.
Lipids Nov, 2004 | Pubmed ID: 15726819
Coenzyme A: back in action.
Progress in lipid research Mar-May, 2005 | Pubmed ID: 15893380
Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters.
The Journal of biological chemistry Sep, 2005 | Pubmed ID: 16040613
Biochemical properties of human pantothenate kinase 2 isoforms and mutations linked to pantothenate kinase-associated neurodegeneration.
The Journal of biological chemistry Jan, 2006 | Pubmed ID: 16272150
Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli.
Journal of medicinal chemistry Jan, 2006 | Pubmed ID: 16392800
Two aerobic pathways for the formation of unsaturated fatty acids in Pseudomonas aeruginosa.
Molecular microbiology Apr, 2006 | Pubmed ID: 16573679
Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae.
The Journal of biological chemistry Jun, 2006 | Pubmed ID: 16618705
Structure of RhlG, an essential beta-ketoacyl reductase in the rhamnolipid biosynthetic pathway of Pseudomonas aeruginosa.
The Journal of biological chemistry Jun, 2006 | Pubmed ID: 16624803
Inhibiting bacterial fatty acid synthesis.
The Journal of biological chemistry Jun, 2006 | Pubmed ID: 16648134
Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2.
The Journal of biological chemistry Sep, 2006 | Pubmed ID: 16861741
Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens.
Molecular cell Sep, 2006 | Pubmed ID: 16949372
Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2007 | Pubmed ID: 17242360
Topology and active site of PlsY: the bacterial acylphosphate:glycerol-3-phosphate acyltransferase.
The Journal of biological chemistry Apr, 2007 | Pubmed ID: 17308305
Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.
Chemistry & biology Mar, 2007 | Pubmed ID: 17379144
Crystal structure and allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I.
Journal of molecular biology Jun, 2007 | Pubmed ID: 17451745
Identification of a soluble diacylglycerol kinase required for lipoteichoic acid production in Bacillus subtilis.
The Journal of biological chemistry Jul, 2007 | Pubmed ID: 17535816
Coupling of fatty acid and phospholipid synthesis in Bacillus subtilis.
Journal of bacteriology Aug, 2007 | Pubmed ID: 17557823
Localization and regulation of mouse pantothenate kinase 2.
FEBS letters Oct, 2007 | Pubmed ID: 17825826
A Pseudomonas aeruginosa transcription factor that senses fatty acid structure.
Molecular microbiology Nov, 2007 | Pubmed ID: 17877713
Membrane lipid homeostasis in bacteria.
Nature reviews. Microbiology Mar, 2008 | Pubmed ID: 18264115
RhlA converts beta-hydroxyacyl-acyl carrier protein intermediates in fatty acid synthesis to the beta-hydroxydecanoyl-beta-hydroxydecanoate component of rhamnolipids in Pseudomonas aeruginosa.
Journal of bacteriology May, 2008 | Pubmed ID: 18326581
Thematic review series: Glycerolipids. Acyltransferases in bacterial glycerophospholipid synthesis.
Journal of lipid research Sep, 2008 | Pubmed ID: 18369234
Analysis of the Staphylococcus aureus DgkB structure reveals a common catalytic mechanism for the soluble diacylglycerol kinases.
Structure (London, England : 1993) Jul, 2008 | Pubmed ID: 18611377
PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa.
The Journal of biological chemistry Oct, 2008 | Pubmed ID: 18728009
Transcriptional regulation in bacterial membrane lipid synthesis.
Journal of lipid research Apr, 2009 | Pubmed ID: 18941141
Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria.
ChemMedChem Dec, 2008 | Pubmed ID: 19016283
Molecular determinants for interfacial binding and conformational change in a soluble diacylglycerol kinase.
The Journal of biological chemistry Mar, 2009 | Pubmed ID: 19112175
Structural modification of acyl carrier protein by butyryl group.
Protein science : a publication of the Protein Society Jan, 2009 | Pubmed ID: 19177367
Acyl-Acyl carrier protein regulates transcription of fatty acid biosynthetic genes via the FabT repressor in Streptococcus pneumoniae.
The Journal of biological chemistry Jun, 2009 | Pubmed ID: 19376778
Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis.
The Journal of biological chemistry Oct, 2009 | Pubmed ID: 19666474
Opening a new path to lipoic acid.
Journal of bacteriology Nov, 2009 | Pubmed ID: 19734307
Transcriptional regulation of membrane lipid homeostasis in Escherichia coli.
The Journal of biological chemistry Dec, 2009 | Pubmed ID: 19854834
FabH selectivity for anteiso branched-chain fatty acid precursors in low-temperature adaptation in Listeria monocytogenes.
FEMS microbiology letters Dec, 2009 | Pubmed ID: 19863661
DesT coordinates the expression of anaerobic and aerobic pathways for unsaturated fatty acid biosynthesis in Pseudomonas aeruginosa.
Journal of bacteriology Jan, 2010 | Pubmed ID: 19880602
Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state.
PloS one Jun, 2010 | Pubmed ID: 20559429
Structural basis for the transcriptional regulation of membrane lipid homeostasis.
Nature structural & molecular biology Aug, 2010 | Pubmed ID: 20639888
Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.
Chemistry & biology Aug, 2010 | Pubmed ID: 20797618
A rainbow coalition of lipid transcriptional regulators.
Molecular microbiology Oct, 2010 | Pubmed ID: 20941840
A σW-dependent stress response in Bacillus subtilis that reduces membrane fluidity.
Molecular microbiology Jul, 2011 | Pubmed ID: 21542858
Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?
Current opinion in microbiology Oct, 2011 | Pubmed ID: 21862391
Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2011 | Pubmed ID: 21876172
Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway.
Molecular cell Nov, 2011 | Pubmed ID: 22055190
Cancer-associated isocitrate dehydrogenase mutations inactivate NADPH-dependent reductive carboxylation.
The Journal of biological chemistry Apr, 2012 | Pubmed ID: 22442146
Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria.
Bioorganic & medicinal chemistry Aug, 2012 | Pubmed ID: 22795901
Will the initiator of fatty acid synthesis in Pseudomonas aeruginosa please stand up?
Journal of bacteriology Oct, 2012 | Pubmed ID: 22821980
Membrane disruption by antimicrobial fatty acids releases low-molecular-weight proteins from Staphylococcus aureus.
Journal of bacteriology Oct, 2012 | Pubmed ID: 22843840
Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1.
Cell host & microbe Sep, 2012 | Pubmed ID: 22980328
Phosphatidic acid synthesis in bacteria.
Biochimica et biophysica acta Mar, 2013 | Pubmed ID: 22981714
Preface: phospholipids and phospholipid metabolism.
Biochimica et biophysica acta Mar, 2013 | Pubmed ID: 23369660
Perturbation of Staphylococcus aureus gene expression by the enoyl-acyl carrier protein reductase inhibitor AFN-1252.
Antimicrobial agents and chemotherapy May, 2013 | Pubmed ID: 23459481
Bacterial lipids: metabolism and membrane homeostasis.
Progress in lipid research Jul, 2013 | Pubmed ID: 23500459
Staphylococcus aureus fatty acid auxotrophs do not proliferate in mice.
Antimicrobial agents and chemotherapy Nov, 2013 | Pubmed ID: 23979734
Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI).
The Journal of biological chemistry Dec, 2013 | Pubmed ID: 24189061
Phosphatidylglycerol homeostasis in glycerol-phosphate auxotrophs of Staphylococcus aureus.
BMC microbiology Nov, 2013 | Pubmed ID: 24238430
The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorganic & medicinal chemistry Apr, 2014 | Pubmed ID: 24613625
Incorporation of extracellular fatty acids by a fatty acid kinase-dependent pathway in Staphylococcus aureus.
Molecular microbiology Apr, 2014 | Pubmed ID: 24673884
Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening.
Bioorganic & medicinal chemistry letters Jun, 2014 | Pubmed ID: 24755430
Pank1 deletion in leptin-deficient mice reduces hyperglycaemia and hyperinsulinaemia and modifies global metabolism without affecting insulin resistance.
Diabetologia Jul, 2014 | Pubmed ID: 24781151
Type II fatty acid synthesis is essential for the replication of Chlamydia trachomatis.
The Journal of biological chemistry Aug, 2014 | Pubmed ID: 24958721
Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2014 | Pubmed ID: 25002480
FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus.
Antimicrobial agents and chemotherapy Feb, 2015 | Pubmed ID: 25403676
A thioesterase bypasses the requirement for exogenous fatty acids in the plsX deletion of Streptococcus pneumoniae.
Molecular microbiology Apr, 2015 | Pubmed ID: 25534847
A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.
Journal of medicinal chemistry Feb, 2015 | Pubmed ID: 25569308
How bacterial pathogens eat host lipids: implications for the development of fatty acid synthesis therapeutics.
The Journal of biological chemistry Mar, 2015 | Pubmed ID: 25648887
Chlamydia trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis.
The Journal of biological chemistry Jul, 2015 | Pubmed ID: 25995447
Discovery of bacterial fatty acid synthase type II inhibitors using a novel cellular bioluminescent reporter assay.
Antimicrobial agents and chemotherapy Sep, 2015 | Pubmed ID: 26169404
Chlamydia trachomatis Scavenges Host Fatty Acids for Phospholipid Synthesis via an Acyl-Acyl Carrier Protein Synthetase.
The Journal of biological chemistry Sep, 2015 | Pubmed ID: 26195634
Maternal bile acid transporter deficiency promotes neonatal demise.
Nature communications Sep, 2015 | Pubmed ID: 26416771
Correction of a genetic deficiency in pantothenate kinase 1 using phosphopantothenate replacement therapy.
Molecular genetics and metabolism Dec, 2015 | Pubmed ID: 26549575
Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria.
The Journal of biological chemistry Jan, 2016 | Pubmed ID: 26567338
Biochemical Roles for Conserved Residues in the Bacterial Fatty Acid-binding Protein Family.
The Journal of biological chemistry Mar, 2016 | Pubmed ID: 26774272
Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) Antibiotics.
Cold Spring Harbor perspectives in medicine Mar, 2016 | Pubmed ID: 26931811
A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome.
Antimicrobial agents and chemotherapy 07, 2016 | Pubmed ID: 27161626
Allosteric Regulation of Mammalian Pantothenate Kinase.
The Journal of biological chemistry Oct, 2016 | Pubmed ID: 27555321
Bacterial fatty acid metabolism in modern antibiotic discovery.
Biochimica et biophysica acta. Molecular and cell biology of lipids Nov, 2017 | Pubmed ID: 27668701
Enoyl-Acyl Carrier Protein Reductase I (FabI) Is Essential for the Intracellular Growth of Listeria monocytogenes.
Infection and immunity Dec, 2016 | Pubmed ID: 27736774
Pyruvate Oxidase as a Critical Link between Metabolism and Capsule Biosynthesis in Streptococcus pneumoniae.
PLoS pathogens Oct, 2016 | Pubmed ID: 27760231
T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions.
The Journal of biological chemistry Jan, 2017 | Pubmed ID: 27903651
Excess coenzyme A reduces skeletal muscle performance and strength in mice overexpressing human PANK2.
Molecular genetics and metabolism 04, 2017 | Pubmed ID: 28189602
Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation.
Cell reports 06, 2017 | Pubmed ID: 28591579
Exogenous fatty acid metabolism in bacteria.
Biochimie Oct, 2017 | Pubmed ID: 28668270
A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer.
Nature structural & molecular biology Aug, 2017 | Pubmed ID: 28714993
Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in .
mBio 08, 2017 | Pubmed ID: 28765222
The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Dihydropteroate Synthase.
Frontiers in microbiology , 2018 | Pubmed ID: 30065703
Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis.
Frontiers in microbiology , 2018 | Pubmed ID: 30319589
A therapeutic approach to pantothenate kinase associated neurodegeneration.
Nature communications 10, 2018 | Pubmed ID: 30352999
Acyl-chain selectivity and physiological roles of fatty acid-binding proteins.
The Journal of biological chemistry 01, 2019 | Pubmed ID: 30429218
Human pantothenate kinase 4 is a pseudo-pantothenate kinase.
Protein science : a publication of the Protein Society Jun, 2019 | Pubmed ID: 30927326
Oleate hydratase from protects against palmitoleic acid, the major antimicrobial fatty acid produced by mammalian skin.
The Journal of biological chemistry Jun, 2019 | Pubmed ID: 31018965
Disruption of Glycolysis by Nutritional Immunity Activates a Two-Component System That Coordinates a Metabolic and Antihost Response by Staphylococcus aureus.
mBio Aug, 2019 | Pubmed ID: 31387906
A fatty acid binding protein of facilitates the acquisition of host polyunsaturated fatty acids.
The Journal of biological chemistry Sep, 2019 | Pubmed ID: 31530637
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