Amy L. Winship
Development and Stem Cells Program,
Monash Biomedicine Discovery Institute,
and Department of Anatomy and Developmental Biology,
Development and Stem Cells Program, Monash Biomedicine Discovery Institute, and Department of Anatomy and Developmental Biology,
Biomedicine Discovery Institute,
Department of Anatomy and Developmental Biology,
Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology
Monash University
Dr Winship is an Australian Research Council DECRA Fellow (2021-2023) in the Ovarian Biology Laboratory at Monash Biomedicine Discovery Institute.
She obtained her PhD in 2016 at the Hudson Institute of Medical Research, focused on defining the role of cytokines in the female reproductive tract and reproductive cancer.
Her current research examines the essential role of DNA repair capacity in regulating quality control of the female germline. She recently revealed the first evidence for a key role of intrinsic DNA break repair in response to endogenous DNA damage (i.e. resulting from normal cellular processes) to safeguard primordial oocyte number, genetic integrity and reproductive capacity.
Additionally, she is establishing her own research niche, capitalising on her background in uterine and placental biology, as well as oncofertility. This research addresses a fundamental knowledge gap, largely ignored by the fertility preservation field – do cancer therapies damage the uterus?
Her research is highly relevant to population health in Australia in context of fertility of female cancer survivors and maternal ageing.
Effects of Estrogens on Adipokines and Glucose Homeostasis in Female Aromatase Knockout Mice.
PloS one , 2015 | Pubmed ID: 26317527
Interleukin-11 alters placentation and causes preeclampsia features in mice.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2015 | Pubmed ID: 26655736
Targeting Interleukin-11 Receptor-α Impairs Human Endometrial Cancer Cell Proliferation and Invasion In Vitro and Reduces Tumor Growth and Metastasis In Vivo.
Molecular cancer therapeutics 04, 2016 | Pubmed ID: 26846819
The importance of DNA repair for maintaining oocyte quality in response to anti-cancer treatments, environmental toxins and maternal ageing.
Human reproduction update Mar, 2018 | Pubmed ID: 29377997
Dacarbazine depletes the ovarian reserve in mice and depletion is enhanced with age.
Scientific reports 04, 2018 | Pubmed ID: 29695822
Maternal low-protein diet programmes low ovarian reserve in offspring
Reproduction (Cambridge, England) 10, 2018 | Pubmed ID: 29991566
Maternal low-protein diet programmes low ovarian reserve in offspring
Reproduction (Cambridge, England) 10, 2018 | Pubmed ID: 30306601
Vincristine Chemotherapy Induces Atresia of Growing Ovarian Follicles in Mice.
Toxicological sciences : an official journal of the Society of Toxicology 05, 2019 | Pubmed ID: 30657998
Do cancer therapies damage the uterus and compromise fertility?
Human reproduction update Feb, 2020 | Pubmed ID: 31863097
The PARP inhibitor, olaparib, depletes the ovarian reserve in mice: implications for fertility preservation.
Human reproduction (Oxford, England) Aug, 2020 | Pubmed ID: 32604417
Flotillin-1 protein is upregulated in human endometrial cancer and localization shifts from epithelial to stromal with increasing tumor grade.
Cancer investigation , 2016 | Pubmed ID: 26682635
Fibulin-5 localisation in human endometrial cancer shifts from epithelial to stromal with increasing tumour grade, and silencing promotes endometrial epithelial cancer cell proliferation.
Oncology letters Jul, 2016 | Pubmed ID: 27347195
Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study.
BMJ open 11, 2019 | Pubmed ID: 31772111
Comparison of methods for quantifying primordial follicles in the mouse ovary.
Journal of ovarian research Oct, 2020 | Pubmed ID: 33054849
Prolonged atrazine exposure beginning and adult uterine morphology in mice.
Journal of developmental origins of health and disease Feb, 2022 | Pubmed ID: 33781367
Development of an embryo transfer model to study uterine contributions to pregnancy in mice.
Reproduction & fertility Jan, 2022 | Pubmed ID: 35198982
Checkpoint inhibitor immunotherapy diminishes oocyte number and quality in mice.
Nature cancer Aug, 2022 | Pubmed ID: 36008687
Melatonin as an oncostatic agent: Review of the modulation of tumor microenvironment and overcoming multidrug resistance.
Biochimie Nov, 2022 | Pubmed ID: 36116742
Does single-strand DNA break repair capacity influence oocyte maintenance and quality?
Reproduction (Cambridge, England) Dec, 2022 | Pubmed ID: 36215096
Beyond apoptosis: evidence of other regulated cell death pathways in the ovary throughout development and life.
Human reproduction update Feb, 2023 | Pubmed ID: 36857094
Radiotherapy exposure directly damages the uterus and causes pregnancy loss.
JCI insight Mar, 2023 | Pubmed ID: 36946464
Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
Meaghan J. Griffiths*,1,2,
Jordan N. Higgins*,1,
Fiona L. Cousins3,
Lauren R. Alesi1,
Amy L. Winship*,1,
Karla J. Hutt*,1
1Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University,
2Gynaecology Research Centre, Royal Women’s Hospital and Department of Obstetrics and Gynaecology, University of Melbourne,
3The Ritchie Centre, Hudson Institute for Medical Research and Department of Obstetrics and Gynaecology, Monash University
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