Department of Pediatrics
Sandra Lawrynowicz Leibel is an Assistant Professor in the Division of Neonatology, Department of Pediatrics, UCSD School of Medicine in San Diego, California. She graduated Medical School at the top of her class at Jagiellonian University in Krakow, Poland, completed Pediatric Residency at Primary Children's Hospital in Salt Lake City, Utah and Neonatal Fellowship at Washington University in St. Louis. She was recruited to the Physician Scientist program at the Hospital for Sick Children in Toronto and completed a Master degree in Lung Biology at the University of Toronto.
Dr. Leibel's interest in lung biology and surfactant metabolism began in the lab of Drs. F.S. Cole and Aaron Hamvas at Washington University where she studied the regulation of surfactant proteins B and C transcription and reprogrammed patient fibroblasts with a lethal surfactant protein B mutation into induced pluripotent stem cells. She continued her work with iPSCs in the lab of Martin Post at Sick Kids and developed her novel lung organoid differentiation protocol and used lentiviral gene therapy to express SP-B in the mutant line.
Dr. Leibel received CIRM funding to study iPSC derived lung organoids from different backgrounds to study infections, surfactant metabolism and to develop complex co-culture systems by investing the lung organoids with iPSC derived endothelial cells and macrophages.
Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy.
Scientific reports Sep, 2019 | Pubmed ID: 31530844
Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation.
Current protocols in stem cell biology 09, 2020 | Pubmed ID: 32640120
Rethinking Remdesivir: Synthesis, Antiviral Activity and Pharmacokinetics of Oral Lipid Prodrugs.
bioRxiv : the preprint server for biology Jun, 2021 | Pubmed ID: 32869033
Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity.
Science advances Aug, 2021 | Pubmed ID: 34407940
The impact of maternal asthma on the preterm infants' gut metabolome and microbiome (MAP study).
Scientific reports Apr, 2022 | Pubmed ID: 35440708
Leveraging the placenta to advance neonatal care.
Frontiers in pediatrics , 2023 | Pubmed ID: 37255571
EGFR-Driven Lung Adenocarcinomas Co-opt Alveolar Macrophage Metabolism and Function to Support EGFR Signaling and Growth.
Cancer discovery Jan, 2024 | Pubmed ID: 38270272
A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2024 | Pubmed ID: 39028694
The impact of breastfeeding on the preterm infant's microbiome and metabolome: a pilot study.
Pediatric research Aug, 2024 | Pubmed ID: 39138352
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