Translational Research in Pain (TRiP) Program,
Department of Clinical Sciences,
College of Veterinary Medicine,
Comparative Pain Research and Education Center,
Translational Research in Pain (TRiP) Program, Department of Clinical Sciences, College of Veterinary Medicine,
Comparative Pain Research and Education Center, College of Veterinary Medicine
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Surgical trauma and chronically painful conditions--within our comfort level but beyond theirs?
Journal of the American Veterinary Medical Association Jul, 2002 | Pubmed ID: 12118583
Use of thermal threshold response to evaluate the antinociceptive effects of butorphanol in cats.
American journal of veterinary research Aug, 2004 | Pubmed ID: 15334842
Validation of a high-pressure liquid chromatography and fluorescence polarization immunoassay for the determination of methadone in canine plasma.
Therapeutic drug monitoring Jun, 2005 | Pubmed ID: 15905812
Use of hinged transarticular external fixation for adjunctive joint stabilization in dogs and cats: 14 cases (1999-2003).
Journal of the American Veterinary Medical Association Aug, 2005 | Pubmed ID: 16117067
Gastrointestinal tract perforation in dogs treated with a selective cyclooxygenase-2 inhibitor: 29 cases (2002-2003).
Journal of the American Veterinary Medical Association Oct, 2005 | Pubmed ID: 16220672
Improved survival associated with postoperative wound infection in dogs treated with limb-salvage surgery for osteosarcoma.
Annals of surgical oncology Dec, 2005 | Pubmed ID: 16252138
Assessment of a von Frey device for evaluation of the antinociceptive effects of morphine and its application in pharmacodynamic modeling of morphine in dogs.
American journal of veterinary research Sep, 2005 | Pubmed ID: 16261837
Guidelines for safe and effective use of NSAIDs in dogs.
Veterinary therapeutics : research in applied veterinary medicine , 2005 | Pubmed ID: 16299670
Use of a von Frey device for evaluation of pharmacokinetics and pharmacodynamics of morphine after intravenous administration as an infusion or multiple doses in dogs.
American journal of veterinary research Nov, 2005 | Pubmed ID: 16334958
Evaluation of a pressure walkway system for measurement of vertical limb forces in clinically normal dogs.
American journal of veterinary research Feb, 2006 | Pubmed ID: 16454633
Comparison of measurements obtained by use of an electrogoniometer and a universal plastic goniometer for the assessment of joint motion in dogs.
American journal of veterinary research Dec, 2006 | Pubmed ID: 17144796
Nonsteroidal anti-inflammatory drugs in cats: a review.
Veterinary anaesthesia and analgesia Jul, 2007 | Pubmed ID: 17451496
Evaluation of an accelerometer for at-home monitoring of spontaneous activity in dogs.
American journal of veterinary research May, 2007 | Pubmed ID: 17472445
Internal fixation of a femur fracture in an American bullfrog.
Journal of the American Veterinary Medical Association Apr, 2007 | Pubmed ID: 17501663
Evaluation of client-specific outcome measures and activity monitoring to measure pain relief in cats with osteoarthritis.
Journal of veterinary internal medicine May-Jun, 2007 | Pubmed ID: 17552444
Evaluation of a digitally integrated accelerometer-based activity monitor for the measurement of activity in cats.
Veterinary anaesthesia and analgesia Mar, 2008 | Pubmed ID: 17927675
Feline fibrosarcoma: perioperative management.
Compendium (Yardley, PA) Dec, 2007 | Pubmed ID: 18225636
Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs.
American journal of veterinary research Apr, 2008 | Pubmed ID: 18380576
Evaluation of wraps covering the distal aspect of pelvic limbs for prevention of bacterial strike-through in an ex vivo canine model.
Veterinary surgery : VS Jun, 2008 | Pubmed ID: 18564266
Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Sep, 2009 | Pubmed ID: 19274754
Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs.
American journal of veterinary research Oct, 2009 | Pubmed ID: 19795939
DJD-associated pain in cats: what can we do to promote patient comfort?
Journal of feline medicine and surgery Mar, 2010 | Pubmed ID: 20193911
Feline degenerative joint disease.
Veterinary surgery : VS Jan, 2010 | Pubmed ID: 20210938
Evaluation of functional outcome after BFX total hip replacement using a pressure sensitive walkway.
Veterinary surgery : VS Jan, 2010 | Pubmed ID: 20210948
Meniscal mineralization in domestic cats.
Veterinary surgery : VS Jul, 2010 | Pubmed ID: 20345540
Evaluation of the relationship between lesions in the gastroduodenal region and cyclooxygenase expression in clinically normal dogs.
American journal of veterinary research Jun, 2010 | Pubmed ID: 20513177
Cross-sectional study of the prevalence of radiographic degenerative joint disease in domesticated cats.
Veterinary surgery : VS Jul, 2010 | Pubmed ID: 20561321
Evaluation of a midhumeral block of the radial, ulnar, musculocutaneous and median (RUMM block) nerves for analgesia of the distal aspect of the thoracic limb in dogs.
Veterinary surgery : VS Oct, 2010 | Pubmed ID: 20673276
Elbow denervation in dogs: development of an in vivo surgical procedure and pilot testing.
Veterinary journal (London, England : 1997) Nov, 2011 | Pubmed ID: 21111644
Evaluation of intermittent infusion of bupivacaine into surgical wounds of dogs postoperatively.
Veterinary journal (London, England : 1997) Nov, 2011 | Pubmed ID: 21146429
Relationship of orthopedic examination, goniometric measurements, and radiographic signs of degenerative joint disease in cats.
BMC veterinary research Jan, 2012 | Pubmed ID: 22281125
Comparison of body weight distribution, peak vertical force, and vertical impulse as measures of hip joint pain and efficacy of total hip replacement.
Veterinary surgery : VS May, 2012 | Pubmed ID: 22548436
Evaluation of cyclooxygenase protein expression in traumatized versus normal tissues from eastern box turtles (Terrapene carolina carolina).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians Jun, 2012 | Pubmed ID: 22779232
Owner-assessed indices of quality of life in cats and the relationship to the presence of degenerative joint disease.
Journal of feline medicine and surgery Dec, 2012 | Pubmed ID: 23027832
Evaluation of the clinical use of tepoxalin and meloxicam in cats.
Journal of feline medicine and surgery Aug, 2013 | Pubmed ID: 23349526
Variability of performance of wound infusion catheters.
Veterinary anaesthesia and analgesia May, 2013 | Pubmed ID: 23406507
Assessment of cord dorsum potentials from caudal nerves in anesthetized clinically normal adult dogs without or during neuromuscular blockade.
American journal of veterinary research Apr, 2013 | Pubmed ID: 23531070
Associations among exercise duration, lameness severity, and hip joint range of motion in Labrador Retrievers with hip dysplasia.
Journal of the American Veterinary Medical Association Jun, 2013 | Pubmed ID: 23683017
Histological and molecular characterisation of feline humeral condylar osteoarthritis.
BMC veterinary research Jun, 2013 | Pubmed ID: 23731511
Drug therapy for acute and chronic pain in the cat.
International journal of pharmaceutical compounding Sep-Oct, 2002 | Pubmed ID: 23979411
Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies.
Journal of feline medicine and surgery Jun, 2014 | Pubmed ID: 24217707
Feasibility and repeatability of cold and mechanical quantitative sensory testing in normal dogs.
Veterinary journal (London, England : 1997) Feb, 2014 | Pubmed ID: 24268475
Biomechanical evaluation of the influence of an intramedullary pin on the stability of a feline ilial fracture model stabilized with a bone plate.
Veterinary surgery : VS Feb, 2014 | Pubmed ID: 24372159
Relationship between mechanical thresholds and limb use in dogs with coxofemoral joint oa-associated pain and the modulating effects of pain alleviation from total hip replacement on mechanical thresholds.
Veterinary surgery : VS Jul, 2014 | Pubmed ID: 24512340
Ex vivo effect of gold nanoparticles on porcine synovial membrane.
Tissue barriers Apr, 2013 | Pubmed ID: 24665389
The challenge of evaluating pain and a pre-incisional local anesthetic block.
PeerJ , 2014 | Pubmed ID: 24765575
Clinical trials involving cats: what factors affect owner participation?
Journal of feline medicine and surgery Sep, 2014 | Pubmed ID: 24938313
Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain.
PeerJ , 2015 | Pubmed ID: 25722957
A canine-specific anti-nerve growth factor antibody alleviates pain and improves mobility and function in dogs with degenerative joint disease-associated pain.
BMC veterinary research Apr, 2015 | Pubmed ID: 25926287
Clinical safety of robenacoxib in feline osteoarthritis: results of a randomized, blinded, placebo-controlled clinical trial.
Journal of feline medicine and surgery 08, 2016 | Pubmed ID: 26058587
Criterion Validation Testing of Clinical Metrology Instruments for Measuring Degenerative Joint Disease Associated Mobility Impairment in Cats.
PloS one , 2015 | Pubmed ID: 26162101
Defining the local nerve blocks for feline distal thoracic limb surgery: a cadaveric study.
Journal of feline medicine and surgery 10, 2016 | Pubmed ID: 26250858
Analgesic efficacy of intraperitoneal administration of bupivacaine in cats.
Journal of feline medicine and surgery 11, 2016 | Pubmed ID: 26467541
Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis.
Pain 06, 2016 | Pubmed ID: 26901805
Aging in cats: Common physical and functional changes.
Journal of feline medicine and surgery 07, 2016 | Pubmed ID: 27370392
Evaluating aging in cats: How to determine what is healthy and what is disease.
Journal of feline medicine and surgery 07, 2016 | Pubmed ID: 27370393
Alfaxalone Anaesthesia Facilitates Electrophysiological Recordings of Nociceptive Withdrawal Reflexes in Dogs (Canis familiaris).
PloS one , 2016 | Pubmed ID: 27433936
Functional outcome measures in a surgical model of hip osteoarthritis in dogs.
Journal of experimental orthopaedics Dec, 2016 | Pubmed ID: 27525982
Pilot, randomized, placebo-controlled clinical field study to evaluate the effectiveness of bupivacaine liposome injectable suspension for the provision of post-surgical analgesia in dogs undergoing stifle surgery.
BMC veterinary research Aug, 2016 | Pubmed ID: 27531019
Do cats with a cranial cruciate ligament injury and osteoarthritis demonstrate a different gait pattern and behaviour compared to sound cats?
Acta veterinaria Scandinavica Oct, 2016 | Pubmed ID: 27766970
A comparison of serum and plasma cytokine values using a multiplexed assay in cats.
Veterinary immunology and immunopathology Dec, 2016 | Pubmed ID: 27863553
Attitudes of small animal practitioners toward participation in veterinary clinical trials.
Journal of the American Veterinary Medical Association Jan, 2017 | Pubmed ID: 28001115
Evaluation of serum cytokines in cats with and without degenerative joint disease and associated pain.
Veterinary immunology and immunopathology Jan, 2017 | Pubmed ID: 28063477
Repeatability and accuracy testing of a weight distribution platform and comparison to a pressure sensitive walkway to assess static weight distribution.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T Mar, 2017 | Pubmed ID: 28094423
The Use of Functional Data Analysis to Evaluate Activity in a Spontaneous Model of Degenerative Joint Disease Associated Pain in Cats.
PloS one , 2017 | Pubmed ID: 28099449
Pilot evaluation of a novel unilateral onychectomy model and efficacy of an extended release buprenorphine product.
BMC veterinary research Jan, 2017 | Pubmed ID: 28118835
Defining local nerve blocks for feline distal pelvic limb surgery: a cadaveric study.
Journal of feline medicine and surgery Dec, 2017 | Pubmed ID: 28186424
Nocifensive Behaviors in Mice with Radiation-Induced Oral Mucositis.
Radiation research 03, 2017 | Pubmed ID: 28186468
Caregiver placebo effect in analgesic clinical trials for cats with naturally occurring degenerative joint disease-associated pain.
The Veterinary record May, 2017 | Pubmed ID: 28270539
Replicate effects and test-retest reliability of quantitative sensory threshold testing in dogs with and without chronic pain.
Veterinary anaesthesia and analgesia May, 2017 | Pubmed ID: 28528759
Translational pain assessment: could natural animal models be the missing link?
Pain Sep, 2017 | Pubmed ID: 28614187
Chronic maladaptive pain in cats: A review of current and future drug treatment options.
Veterinary journal (London, England : 1997) Dec, 2017 | Pubmed ID: 28887012
Distinct neuronal populations in the basolateral and central amygdala are activated with acute pain, conditioned fear, and fear-conditioned analgesia.
Neuroscience letters Nov, 2017 | Pubmed ID: 28916300
An extended release local anaesthetic: potential for future use in veterinary surgical patients?
Veterinary medicine and science Nov, 2016 | Pubmed ID: 29067198
Spontaneous painful disease in companion animals can facilitate the development of chronic pain therapies for humans.
Osteoarthritis and cartilage 02, 2018 | Pubmed ID: 29180098
Effect of sucralfate on gastric permeability in an ex vivo model of stress-related mucosal disease in dogs.
Journal of veterinary internal medicine Mar, 2018 | Pubmed ID: 29460464
Face validity of a proposed tool for staging canine osteoarthritis: Canine OsteoArthritis Staging Tool (COAST).
Veterinary journal (London, England : 1997) 05, 2018 | Pubmed ID: 29704933
Enrichment Preferences of FIV-Infected and Uninfected Laboratory-Housed Cats.
Viruses 07, 2018 | Pubmed ID: 29970792
Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis.
Pain Nov, 2018 | Pubmed ID: 29994993
Prescribing practices of veterinarians in the treatment of chronic musculoskeletal pain in cats.
Journal of feline medicine and surgery 06, 2019 | Pubmed ID: 30033841
Content validation of a Critical Appraisal Tool for Reviewing Analgesia Studies (CATRAS) involving subjects incapable of self-reporting pain.
Pain reports Jul-Aug, 2018 | Pubmed ID: 30123860
Assessment of a novel nanoparticle hyperthermia therapy in a murine model of osteosarcoma.
Veterinary surgery : VS Nov, 2018 | Pubmed ID: 30307042
Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari-like malformations and syringomyelia.
Journal of veterinary internal medicine Nov, 2018 | Pubmed ID: 30307645
The pharmacokinetics of gabapentin in cats.
Journal of veterinary internal medicine Nov, 2018 | Pubmed ID: 30307652
Anti-nerve growth factor monoclonal antibodies for the control of pain in dogs and cats.
The Veterinary record Jan, 2019 | Pubmed ID: 30368458
Evaluation of the effect of signalment and owner-reported impairment level on accelerometer-measured changes in activity in osteoarthritic dogs receiving a non-steroidal anti-inflammatory.
Veterinary journal (London, England : 1997) Dec, 2018 | Pubmed ID: 30503544
Quantitative sensory testing in dogs with painful disease: A window to pain mechanisms?
Veterinary journal (London, England : 1997) Jan, 2019 | Pubmed ID: 30606437
Characterization of gene expression in naturally occurring feline degenerative joint disease-associated pain.
Veterinary journal (London, England : 1997) Jan, 2019 | Pubmed ID: 30606438
Clinical measurements performed during alfaxalone total intravenous anaesthesia for radiography and neurophysiological investigations in dogs.
Veterinary anaesthesia and analgesia Jul, 2019 | Pubmed ID: 31178411
Measurement of chronic pain in companion animals: Discussions from the Pain in Animals Workshop (PAW) 2017.
Veterinary journal (London, England : 1997) Aug, 2019 | Pubmed ID: 31383423
Immune dysregulation and osteosarcoma: Staphylococcus aureus downregulates TGF-β and heightens the inflammatory signature in human and canine macrophages suppressed by osteosarcoma.
Veterinary and comparative oncology Mar, 2020 | Pubmed ID: 31420936
A novel device to measure static hindlimb weight-bearing forces in pronograde rodents.
Journal of neuroscience methods 12, 2019 | Pubmed ID: 31465781
Measurement of chronic pain in companion animals: Priorities for future research and development based on discussions from the Pain in Animals Workshop (PAW) 2017.
Veterinary journal (London, England : 1997) Oct, 2019 | Pubmed ID: 31554586
Evaluation and comparison of pain questionnaires for clinical screening of osteoarthritis in cats.
The Veterinary record 12, 2019 | Pubmed ID: 31619513
The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis.
BMC veterinary research Oct, 2019 | Pubmed ID: 31623621
Pet Dogs with Subclinical Acute Radiodermatitis Experience Widespread Somatosensory Sensitization.
Radiation research 03, 2020 | Pubmed ID: 31877255
Correlation of activity data in normal dogs to distance traveled.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire Jan, 2020 | Pubmed ID: 31920217
The effect of spontaneous osteoarthritis on conditioned pain modulation in the canine model.
Scientific reports 02, 2020 | Pubmed ID: 32015421
Impact of radiation dose and pre-treatment pain levels on survival in dogs undergoing radiotherapy with or without chemotherapy for presumed extremity osteosarcoma.
Veterinary and comparative oncology Dec, 2020 | Pubmed ID: 32048435
Correlation of Artemin and GFRα3 With Osteoarthritis Pain: Early Evidence From Naturally Occurring Osteoarthritis-Associated Chronic Pain in Dogs.
Frontiers in neuroscience , 2020 | Pubmed ID: 32116521
Early Neonatal Pain-A Review of Clinical and Experimental Implications on Painful Conditions Later in Life.
Frontiers in pediatrics , 2020 | Pubmed ID: 32117835
Development of a checklist for the detection of degenerative joint disease-associated pain in cats.
Journal of feline medicine and surgery 12, 2020 | Pubmed ID: 32122226
Glaucoma-associated pain results in mechanical sensitivity changes in dogs: A pilot study.
Veterinary ophthalmology Mar, 2021 | Pubmed ID: 32608141
Local Administration of Carboplatin in Poloxamer 407 After an Ulnar Osteosarcoma Removal in a Dog.
Journal of the American Animal Hospital Association Nov, 2020 | Pubmed ID: 33113558
Protease activated receptor 2 and matriptase expression in the joints of cats with and without osteoarthritis.
Journal of feline medicine and surgery 08, 2021 | Pubmed ID: 33284033
Correction to: The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis.
BMC veterinary research Dec, 2020 | Pubmed ID: 33323102
A functional linear modeling approach to sleep-wake cycles in dogs.
Scientific reports 12, 2020 | Pubmed ID: 33335259
Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association Mar, 2021 | Pubmed ID: 33350542
Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain.
Scientific reports 03, 2021 | Pubmed ID: 33758254
Robenacoxib shows efficacy for the treatment of chronic degenerative joint disease-associated pain in cats: a randomized and blinded pilot clinical trial.
Scientific reports 04, 2021 | Pubmed ID: 33833276
Novel approach to modeling high-frequency activity data to assess therapeutic effects of analgesics in chronic pain conditions.
Scientific reports 04, 2021 | Pubmed ID: 33833306
Refinement of the Feline Musculoskeletal Pain Index (FMPI) and development of the short-form FMPI.
Journal of feline medicine and surgery May, 2021 | Pubmed ID: 34002643
Defining the rate of, and factors influencing, radiographic progression of osteoarthritis of the canine hip joint.
The Veterinary record Jun, 2021 | Pubmed ID: 34118160
Efficacy and Safety of an Anti-nerve Growth Factor Antibody (Frunevetmab) for the Treatment of Degenerative Joint Disease-Associated Chronic Pain in Cats: A Multisite Pilot Field Study.
Frontiers in veterinary science , 2021 | Pubmed ID: 34124212
Clinical safety of robenacoxib in cats with chronic musculoskeletal disease.
Journal of veterinary internal medicine Sep, 2021 | Pubmed ID: 34196973
Irradiation of the Normal Murine Tongue Causes Upregulation and Activation of Transient Receptor Potential (TRP) Ion Channels.
Radiation research Oct, 2021 | Pubmed ID: 34324688
Behavioral phenotyping of cancer pain in domesticated cats with naturally occurring squamous cell carcinoma of the tongue: initial validation studies provide evidence for regional and widespread algoplasticity.
PeerJ , 2021 | Pubmed ID: 34458024
Biological resurfacing in a canine model of hip osteoarthritis.
Science advances Sep, 2021 | Pubmed ID: 34524840
Rachael M. Cunningham1,2,
Rachel M. Park1,2,
David Knazovicky3,
B. Duncan X. Lascelles2,4,5,6,
Margaret E. Gruen1,2,4
1Comparative Behavioral Research, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University,
2Translational Research in Pain (TRiP) Program, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University,
3Small Animal Orthopedic Surgery, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University,
4Comparative Pain Research and Education Center, College of Veterinary Medicine, North Carolina State University,
5Thurston Arthritis Center, UNC School of Medicine, University of North Carolina - Chapel Hill,
6Center for Translational Pain Research, Department of Anesthesiology, Duke University
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