Medizinisches Proteom-Center,
Medical Faculty,
Medical Proteome Analysis,
Center for Proteindiagnostics (PRODI),
Medizinisches Proteom-Center, Medical Faculty,
Medical Proteome Analysis, Center for Proteindiagnostics (PRODI)
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Differential analysis of phosphorylated proteins in resting and thrombin-stimulated human platelets.
Analytical and bioanalytical chemistry Aug, 2003 | Pubmed ID: 12904942
"Does understanding the brain need proteomics and does understanding proteomics need brains?"--Second HUPO HBPP Workshop hosted in Paris.
Proteomics Jul, 2004 | Pubmed ID: 15221752
Two-dimensional polyacrylamide gel electrophoresis for platelet proteomics.
Methods in molecular biology (Clifton, N.J.) , 2004 | Pubmed ID: 15308816
Tryptic transpeptidation products observed in proteome analysis by liquid chromatography-tandem mass spectrometry.
Proteomics Mar, 2005 | Pubmed ID: 15759313
Application of fluorescence difference gel electrophoresis saturation labelling for the analysis of microdissected precursor lesions of pancreatic ductal adenocarcinoma.
Proteomics Jul, 2005 | Pubmed ID: 15924292
HUPO BPP Workshop on Mouse Models for Neurodegeneration--Choosing the right models.
Proteomics Sep, 2005 | Pubmed ID: 16127735
5th HUPO BPP Bioinformatics Meeting at the European Bioinformatics Institute in Hinxton, UK--Setting the analysis frame.
Proteomics Sep, 2005 | Pubmed ID: 16167371
Pilot study of the Human Proteome Organisation Brain Proteome Project: applying different 2-DE techniques to monitor proteomic changes during murine brain development.
Proteomics Sep, 2006 | Pubmed ID: 16927428
Multidimensional chromatography: a powerful tool for the analysis of membrane proteins in mouse brain.
Journal of proteome research Jan, 2007 | Pubmed ID: 17203954
A new fast method for nanoLC-MALDI-TOF/TOF-MS analysis using monolithic columns for peptide preconcentration and separation in proteomic studies.
Journal of proteome research Feb, 2007 | Pubmed ID: 17269720
The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease.
Progress in neurobiology Aug, 2008 | Pubmed ID: 18603345
Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε.
BMC cancer Apr, 2011 | Pubmed ID: 21492476
A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes.
BMC systems biology , 2011 | Pubmed ID: 21548957
A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP.
Journal of neural transmission (Vienna, Austria : 1996) Mar, 2012 | Pubmed ID: 21960009
Sense and nonsense of pathway analysis software in proteomics.
Journal of proteome research Dec, 2011 | Pubmed ID: 21978018
Transplantation of human umbilical cord blood cells mediated beneficial effects on apoptosis, angiogenesis and neuronal survival after hypoxic-ischemic brain injury in rats.
Cell and tissue research Jun, 2012 | Pubmed ID: 22526623
The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease.
Molecular & cellular proteomics : MCP Nov, 2012 | Pubmed ID: 22879628
A ternary complex consisting of AICD, FE65, and TIP60 down-regulates Stathmin1.
Biochimica et biophysica acta Jan, 2013 | Pubmed ID: 22902274
Stepwise isolation of human peripheral erythrocytes, T lymphocytes, and monocytes for blood cell proteomics.
Proteomics. Clinical applications Oct, 2012 | Pubmed ID: 22930584
A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients.
Molecular & cellular proteomics : MCP Jan, 2013 | Pubmed ID: 23115302
Changes in Interleukin-1 alpha serum levels after transplantation of umbilical cord blood cells in a model of perinatal hypoxic-ischemic brain damage.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft Mar, 2013 | Pubmed ID: 23123184
Proteomic analysis of alterations induced by perinatal hypoxic-ischemic brain injury.
Journal of proteome research Dec, 2012 | Pubmed ID: 23153068
Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.
BMC cell biology Mar, 2013 | Pubmed ID: 23506001
FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease.
Journal of cell science Jun, 2013 | Pubmed ID: 23572515
Early diagnosis of neurodegenerative diseases - the long awaited Holy Grail and bottleneck of modern brain research - 19th HUPO BPP workshop: May 22-24, 2013, Dortmund, Germany.
Proteomics Oct, 2013 | Pubmed ID: 24108682
Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes.
BMC evolutionary biology Nov, 2013 | Pubmed ID: 24195737
Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.
Molecular & cellular proteomics : MCP Feb, 2014 | Pubmed ID: 24284412
Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.
Human molecular genetics Aug, 2014 | Pubmed ID: 24619358
Internal ribosomal entry site (IRES) activity generates endogenous carboxyl-terminal domains of Cx43 and is responsive to hypoxic conditions.
The Journal of biological chemistry Jul, 2014 | Pubmed ID: 24872408
Frontiers in neurodegeneration--new insights and prospects--20th HUPO BPP Workshop: 15 September 2013, Yokohama, Japan.
Proteomics Jun, 2014 | Pubmed ID: 24903697
Chromophore composition of the phycobiliprotein Cr-PC577 from the cryptophyte Hemiselmis pacifica.
Photosynthesis research Dec, 2014 | Pubmed ID: 25134685
Identification of a novel human LAP1 isoform that is regulated by protein phosphorylation.
PloS one , 2014 | Pubmed ID: 25461922
The challenge of on-tissue digestion for MALDI MSI- a comparison of different protocols to improve imaging experiments.
Analytical and bioanalytical chemistry Mar, 2015 | Pubmed ID: 25687681
Indirect protein quantification of drug-transforming enzymes using peptide group-specific immunoaffinity enrichment and mass spectrometry.
Scientific reports Mar, 2015 | Pubmed ID: 25737130
Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2015 | Pubmed ID: 26116512
Low-bias phosphopeptide enrichment from scarce samples using plastic antibodies.
Scientific reports Jul, 2015 | Pubmed ID: 26126808
Amyloid-β as a biomarker for Alzheimer's disease: quantification methods in body fluids.
Expert review of proteomics Aug, 2015 | Pubmed ID: 26153725
Myofibrillar instability exacerbated by acute exercise in filaminopathy.
Human molecular genetics Dec, 2015 | Pubmed ID: 26472074
Nuclear spheres modulate the expression of BEST1 and GADD45G.
Cellular signalling Jan, 2016 | Pubmed ID: 26521045
PAA: an R/bioconductor package for biomarker discovery with protein microarrays.
Bioinformatics (Oxford, England) 05, 2016 | Pubmed ID: 26803161
Key players in neurodegenerative disorders in focus-New insights into the proteomic profile of Alzheimer's disease, schizophrenia, ALS, and multiple sclerosis-24th HUPO BPP Workshop: September 29, 2015, Vancouver, Canada.
Proteomics Apr, 2016 | Pubmed ID: 26872682
Mutant desmin substantially perturbs mitochondrial morphology, function and maintenance in skeletal muscle tissue.
Acta neuropathologica 09, 2016 | Pubmed ID: 27393313
Membrane tethering of APP c-terminal fragments is a prerequisite for T668 phosphorylation preventing nuclear sphere generation.
Cellular signalling 11, 2016 | Pubmed ID: 27534516
Validation of molecularly imprinted polymers for side chain selective phosphopeptide enrichment.
Journal of chromatography. A Nov, 2016 | Pubmed ID: 27765418
Proteomic characterization of neuromelanin granules isolated from human substantia nigra by laser-microdissection.
Scientific reports 11, 2016 | Pubmed ID: 27841354
Proteomics of rimmed vacuoles define new risk allele in inclusion body myositis.
Annals of neurology Feb, 2017 | Pubmed ID: 28009083
Morphological Plasticity of Emerging Purkinje Cells in Response to Exogenous VEGF.
Frontiers in molecular neuroscience , 2017 | Pubmed ID: 28194096
Metabolic profiling of body fluids and multivariate data analysis.
MethodsX , 2017 | Pubmed ID: 28275554
Strategies in relative and absolute quantitative mass spectrometry based proteomics.
Biological chemistry 05, 2017 | Pubmed ID: 28282288
Spatial and molecular resolution of diffuse malignant mesothelioma heterogeneity by integrating label-free FTIR imaging, laser capture microdissection and proteomics.
Scientific reports 03, 2017 | Pubmed ID: 28358042
BioInfra.Prot: A comprehensive proteomics workflow including data standardization, protein inference, expression analysis and data publication.
Journal of biotechnology Nov, 2017 | Pubmed ID: 28606611
Protective effects on the retina after ranibizumab treatment in an ischemia model.
PloS one , 2017 | Pubmed ID: 28800629
Distinct metabolomic signature in cerebrospinal fluid in early parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society Oct, 2017 | Pubmed ID: 28843022
One gene, two proteins: coordinated production of a copper chaperone by differential transcript formation and translational frameshifting in Escherichia coli.
Molecular microbiology Nov, 2017 | Pubmed ID: 28925527
Molecularly imprinted polymers synthesized via template immobilization on fumed silica nanoparticles for the enrichment of phosphopeptides.
Journal of molecular recognition : JMR 03, 2018 | Pubmed ID: 29024117
Hsp90-downregulation influences the heat-shock response, innate immune response and onset of oocyte development in nematodes.
PloS one , 2017 | Pubmed ID: 29078207
Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.
Autophagy , 2018 | Pubmed ID: 29198173
Editorial: Breakthroughs in top-down proteomics.
Journal of proteomics 03, 2018 | Pubmed ID: 29275042
Label-free identification of myopathological features with coherent anti-Stokes Raman scattering.
Muscle & nerve 09, 2018 | Pubmed ID: 29663456
Characterization of Cerebrospinal Fluid via Data-Independent Acquisition Mass Spectrometry.
Journal of proteome research 10, 2018 | Pubmed ID: 30207155
Landscape of pain in Parkinson's disease: impact of gender differences.
Neurological research Jan, 2019 | Pubmed ID: 30311863
Protein Inference Using PIA Workflows and PSI Standard File Formats.
Journal of proteome research 02, 2019 | Pubmed ID: 30474983
Protein variability in cerebrospinal fluid and its possible implications for neurological protein biomarker research.
PloS one , 2018 | Pubmed ID: 30496192
Quantifying changes in the bacterial thiol redox proteome during host-pathogen interaction.
Redox biology 02, 2019 | Pubmed ID: 30682706
Intricate Crosstalk Between Lipopolysaccharide, Phospholipid and Fatty Acid Metabolism in Modulates Proteolysis of LpxC.
Frontiers in microbiology , 2018 | Pubmed ID: 30692974
Integrated Fourier Transform Infrared Imaging and Proteomics for Identification of a Candidate Histochemical Biomarker in Bladder Cancer.
The American journal of pathology 03, 2019 | Pubmed ID: 30770125
Noninvasive diagnosis of urothelial cancer in urine using DNA hypermethylation signatures-Gender matters.
International journal of cancer 11, 2019 | Pubmed ID: 31008534
The microRNA miR-375-3p and the Tumor Suppressor NDRG2 are Involved in Sporadic Amyotrophic Lateral Sclerosis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology , 2019 | Pubmed ID: 31075191
Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Skeletal Muscle Proteome in Recreationally Active Men.
Nutrients May, 2019 | Pubmed ID: 31091754
IgA autoantibodies against native myelin basic protein in a patient with MS.
Neurology(R) neuroimmunology & neuroinflammation 07, 2019 | Pubmed ID: 31355305
Human tear fluid proteome dataset for usage as a spectral library and for protein modeling.
Data in brief Apr, 2019 | Pubmed ID: 31372408
CSF Sample Preparation for Data-Independent Acquisition.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 31432406
Co-extraction for Metabolomics and Proteomics from a Single CSF Sample.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 31432423
Chaperones in sporadic inclusion body myositis-Validation of proteomic data.
Muscle & nerve 01, 2020 | Pubmed ID: 31644823
CRN2 binds to TIMP4 and MMP14 and promotes perivascular invasion of glioblastoma cells.
European journal of cell biology Dec, 2019 | Pubmed ID: 31677819
Reproducibility, Specificity and Accuracy of Relative Quantification Using Spectral Library-based Data-independent Acquisition.
Molecular & cellular proteomics : MCP 01, 2020 | Pubmed ID: 31699904
A spiked human proteomic dataset from human osteogenic differentiated BMSCs and ASCs for use as a spectral library, for modelling pathways as well as protein mapping.
Data in brief Dec, 2019 | Pubmed ID: 31763404
A metastable subproteome underlies inclusion formation in muscle proteinopathies.
Acta neuropathologica communications 12, 2019 | Pubmed ID: 31796104
Let me infuse this for you - A way to solve the first YPIC challenge.
EuPA open proteomics Mar, 2019 | Pubmed ID: 31890549
The product PACRG promotes TNF signaling by stabilizing LUBAC.
Science signaling 02, 2020 | Pubmed ID: 32019898
Blood Contamination in CSF and Its Impact on Quantitative Analysis of Alpha-Synuclein.
Cells 02, 2020 | Pubmed ID: 32033488
CalibraCurve: A Tool for Calibration of Targeted MS-Based Measurements.
Proteomics 06, 2020 | Pubmed ID: 32086983
The process of somatic hypermutation increases polyreactivity for central nervous system antigens in primary central nervous system lymphoma.
Haematologica 03, 2021 | Pubmed ID: 32193251
Multiomic elucidation of a coding 99-mer repeat-expansion skeletal muscle disease.
Acta neuropathologica 08, 2020 | Pubmed ID: 32451610
miR-129-5p and miR-130a-3p Regulate VEGFR-2 Expression in Sensory and Motor Neurons during Development.
International journal of molecular sciences May, 2020 | Pubmed ID: 32481647
Glucocorticoid receptor complexes form cooperatively with the Hsp90 co-chaperones Pp5 and FKBPs.
Scientific reports 07, 2020 | Pubmed ID: 32612187
Human cerebrospinal fluid data for use as spectral library, for biomarker research.
Data in brief Oct, 2020 | Pubmed ID: 32775566
What Room for Two-Dimensional Gel-Based Proteomics in a Shotgun Proteomics World?
Proteomes Aug, 2020 | Pubmed ID: 32781532
Homozygous expression of the myofibrillar myopathy-associated p.W2710X filamin C variant reveals major pathomechanisms of sarcomeric lesion formation.
Acta neuropathologica communications 09, 2020 | Pubmed ID: 32887649
How Do the Different Proteomic Strategies Cope with the Complexity of Biological Regulations in a Multi-Omic World? Critical Appraisal and Suggestions for Improvements.
Proteomes Sep, 2020 | Pubmed ID: 32899323
A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease.
Science translational medicine 09, 2020 | Pubmed ID: 32908004
The first versatile human iPSC-based model of ectopic virus induction allows new insights in RNA-virus disease.
Scientific reports 10, 2020 | Pubmed ID: 33033381
New Approaches to Critical Illness Polyneuromyopathy: High-Resolution Neuromuscular Ultrasound Characteristics and Cytokine Profiling.
Neurocritical care 08, 2021 | Pubmed ID: 33236290
Proteomic Characterization of Synaptosomes from Human Substantia Nigra Indicates Altered Mitochondrial Translation in Parkinson's Disease.
Cells 12, 2020 | Pubmed ID: 33276480
MaCPepDB: A Database to Quickly Access All Tryptic Peptides of the UniProtKB.
Journal of proteome research 04, 2021 | Pubmed ID: 33724838
Lysine 53 Acetylation of Cytochrome in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis.
Cells 04, 2021 | Pubmed ID: 33916826
MicroRNAs from extracellular vesicles as a signature for Parkinson's disease.
Clinical and translational medicine 04, 2021 | Pubmed ID: 33931970
Good Old-Fashioned Protein Concentration Determination by Amino Acid Analysis.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 33950480
Protein Quantification Using the "Rapid Western Blot" Approach.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 33950481
Proteome Analysis with Classical 2D-PAGE.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 33950483
Differential Proteome Analysis Using 2D-DIGE.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 33950485
Quantitative Mass Spectrometry-Based Proteomics: An Overview.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 33950486
Establishing a Custom-Fit Data-Independent Acquisition Method for Label-Free Proteomics.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 33950500
HSP-90/kinase complexes are stabilized by the large PPIase FKB-6.
Scientific reports 06, 2021 | Pubmed ID: 34117308
Advanced Fiber Type-Specific Protein Profiles Derived from Adult Murine Skeletal Muscle.
Proteomes Jun, 2021 | Pubmed ID: 34201234
Rat retinae data for use as spectral library, for pathway remodeling as well as protein mapping.
Data in brief Aug, 2021 | Pubmed ID: 34222568
FLNC-Associated Myofibrillar Myopathy: New Clinical, Functional, and Proteomic Data.
Neurology. Genetics Jun, 2021 | Pubmed ID: 34235269
The β-Subunit of Voltage-Gated Calcium Channels Regulates Cardiomyocyte Hypertrophy.
Frontiers in cardiovascular medicine , 2021 | Pubmed ID: 34307509
N471D WASH complex subunit strumpellin knock-in mice display mild motor and cardiac abnormalities and BPTF and KLHL11 dysregulation in brain tissue.
Neuropathology and applied neurobiology Jul, 2021 | Pubmed ID: 34312900
CSF Diagnostics: A Potentially Valuable Tool in Neurodegenerative and Inflammatory Disorders Involving Motor Neurons: A Review.
Diagnostics (Basel, Switzerland) Aug, 2021 | Pubmed ID: 34573864
Nematode CDC-37 and DNJ-13 form complexes and can interact with HSP-90.
Scientific reports Nov, 2021 | Pubmed ID: 34725424
Maximilian Wulf1,2,
Katalin Barkovits-Boeddinghaus1,2,
Paula Sommer1,2,
Karin Schork1,2,
Martin Eisenacher1,2,
Peter Riederer3,4,
Manfred Gerlach5,
Steffen Kösters1,2,
Britta Eggers*,1,2,
Katrin Marcus*,1,2
1Medizinisches Proteom-Center, Medical Faculty, Ruhr-University Bochum,
2Medical Proteome Analysis, Center for Proteindiagnostics (PRODI), Ruhr-University Bochum,
3Center of Mental Health; Clinic and Policlinic for Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg,
4Psychiatry Department of Clinical Research, University of Southern Denmark Odense University Hospital,
5Center of Mental Health, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wuerzburg, University of Wuerzburg
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