Center for Tropical and Emerging Global Diseases,
Department of Cellular Biology
Rick L. Tarleton has not added Biography.
If you are Rick L. Tarleton and would like to personalize this page please email our Author Liaison for assistance.
Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection.
Infection and immunity Nov, 1998 | Pubmed ID: 9784506
Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection.
Infection and immunity Oct, 2002 | Pubmed ID: 12228281
Cutting edge: dysfunctional CD8+ T cells reside in nonlymphoid tissues during chronic Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2003 | Pubmed ID: 12594245
Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR.
Molecular and biochemical parasitology Jun, 2003 | Pubmed ID: 12798506
Genetic immunization with LYT1 or a pool of trans-sialidase genes protects mice from lethal Trypanosoma cruzi infection.
Vaccine Jun, 2003 | Pubmed ID: 12798651
Microarray profiling of gene expression during trypomastigote to amastigote transition in Trypanosoma cruzi.
Molecular and biochemical parasitology Sep, 2003 | Pubmed ID: 12967712
Chagas disease: a role for autoimmunity?
Trends in parasitology Oct, 2003 | Pubmed ID: 14519582
TcruziDB: an integrated Trypanosoma cruzi genome resource.
Nucleic acids research Jan, 2004 | Pubmed ID: 14681430
Inducible nitric oxide synthase is not essential for control of Trypanosoma cruzi infection in mice.
Infection and immunity Jul, 2004 | Pubmed ID: 15213153
Antigen-specific T cells maintain an effector memory phenotype during persistent Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2005 | Pubmed ID: 15661921
A Heuristic method for assigning a false-discovery rate for protein identifications from Mascot database search results.
Molecular & cellular proteomics : MCP Jun, 2005 | Pubmed ID: 15703444
New approaches in vaccine development for parasitic infections.
Cellular microbiology Oct, 2005 | Pubmed ID: 16153238
CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes.
PLoS pathogens Aug, 2006 | Pubmed ID: 16879036
A semi-quantitative GeLC-MS analysis of temporal proteome expression in the emerging nosocomial pathogen Ochrobactrum anthropi.
Genome biology , 2007 | Pubmed ID: 17567905
Immune system recognition of Trypanosoma cruzi.
Current opinion in immunology Aug, 2007 | Pubmed ID: 17651955
TGF-beta regulates pathology but not tissue CD8+ T cell dysfunction during experimental Trypanosoma cruzi infection.
European journal of immunology Oct, 2007 | Pubmed ID: 17823982
The challenges of Chagas Disease-- grim outlook or glimmer of hope.
PLoS medicine Dec, 2007 | Pubmed ID: 18162039
Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease.
Nature medicine May, 2008 | Pubmed ID: 18425131
Stable CD8+ T cell memory during persistent Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2008 | Pubmed ID: 18684955
High throughput selection of effective serodiagnostics for Trypanosoma cruzi infection.
PLoS neglected tropical diseases , 2008 | Pubmed ID: 18841200
HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease.
PLoS neglected tropical diseases , 2008 | Pubmed ID: 18846233
Eliminating Chagas disease: challenges and a roadmap.
BMJ (Clinical research ed.) Apr, 2009 | Pubmed ID: 19366739
Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi.
BMC microbiology May, 2009 | Pubmed ID: 19432966
Chromosome level assembly of the hybrid Trypanosoma cruzi genome.
BMC genomics , 2009 | Pubmed ID: 19486522
Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2009 | Pubmed ID: 19553540
CD8+ T cells in Trypanosoma cruzi infection.
Current opinion in immunology Aug, 2009 | Pubmed ID: 19646853
The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi.
BMC genomics , 2009 | Pubmed ID: 19664227
Chronic human infection with Trypanosoma cruzi drives CD4+ T cells to immune senescence.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2009 | Pubmed ID: 19692645
Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Dec, 2009 | Pubmed ID: 19877967
Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina.
Microbes and infection May, 2010 | Pubmed ID: 20123034
Generation of Trypanosoma cruzi-specific CD8+ T-cell immunity is unaffected by the absence of type I interferon signaling.
Infection and immunity Jul, 2010 | Pubmed ID: 20457790
CD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2010 | Pubmed ID: 20530265
In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds.
PLoS neglected tropical diseases Jul, 2010 | Pubmed ID: 20644616
Widespread, focal copy number variations (CNV) and whole chromosome aneuploidies in Trypanosoma cruzi strains revealed by array comparative genomic hybridization.
BMC genomics , 2011 | Pubmed ID: 21385342
Oral exposure to Trypanosoma cruzi elicits a systemic CD8⁺ T cell response and protection against heterotopic challenge.
Infection and immunity Aug, 2011 | Pubmed ID: 21628516
Methodological advances in drug discovery for Chagas disease.
Expert opinion on drug discovery Jun, 2011 | Pubmed ID: 21712965
Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge.
PLoS neglected tropical diseases Dec, 2011 | Pubmed ID: 22180798
Transgenic parasites accelerate drug discovery.
Trends in parasitology Mar, 2012 | Pubmed ID: 22277131
Inhibitory receptors are expressed by Trypanosoma cruzi-specific effector T cells and in hearts of subjects with chronic Chagas disease.
PloS one , 2012 | Pubmed ID: 22574131
Report of the 2nd Chagas Drug Discovery Consortium meeting, held on 3 November 2010; Atlanta GA, USA.
Expert opinion on drug discovery 09, 2011 | Pubmed ID: 22646217
Is Chagas disease really the "new HIV/AIDS of the Americas"?
PLoS neglected tropical diseases , 2012 | Pubmed ID: 23145193
A systematic review of high quality diagnostic tests for Chagas disease.
PLoS neglected tropical diseases , 2012 | Pubmed ID: 23145201
New, combined, and reduced dosing treatment protocols cure Trypanosoma cruzi infection in mice.
The Journal of infectious diseases Jan, 2014 | Pubmed ID: 23945371
Evidence for the role of vacuolar soluble pyrophosphatase and inorganic polyphosphate in Trypanosoma cruzi persistence.
Molecular microbiology Nov, 2013 | Pubmed ID: 24033456
Perpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogen.
Nature communications , 2013 | Pubmed ID: 24149620
Frequency of IFNγ-producing T cells correlates with seroreactivity and activated T cells during canine Trypanosoma cruzi infection.
Veterinary research Jan, 2014 | Pubmed ID: 24456537
The Trypanosoma cruzi flagellum is discarded via asymmetric cell division following invasion and provides early targets for protective CD8⁺ T cells.
Cell host & microbe Oct, 2014 | Pubmed ID: 25299330
Chagas disease and the london declaration on neglected tropical diseases.
PLoS neglected tropical diseases Oct, 2014 | Pubmed ID: 25299701
CRISPR-Cas9-mediated single-gene and gene family disruption in Trypanosoma cruzi.
mBio Dec, 2014 | Pubmed ID: 25550322
Chemokine receptor 7 (CCR7)-expression and IFNγ production define vaccine-specific canine T-cell subsets.
Veterinary immunology and immunopathology Apr, 2015 | Pubmed ID: 25758065
CD8+ T cells in Trypanosoma cruzi infection.
Seminars in immunopathology May, 2015 | Pubmed ID: 25921214
A framework for ontology-based question answering with application to parasite immunology.
Journal of biomedical semantics , 2015 | Pubmed ID: 26185615
Long-Term Immunity to Trypanosoma cruzi in the Absence of Immunodominant trans-Sialidase-Specific CD8+ T Cells.
Infection and immunity 09, 2016 | Pubmed ID: 27354447
Chagas Disease: A Solvable Problem, Ignored.
Trends in molecular medicine Oct, 2016 | Pubmed ID: 27523778
Recombination-driven generation of the largest pathogen repository of antigen variants in the protozoan Trypanosoma cruzi.
BMC genomics 09, 2016 | Pubmed ID: 27619017
The Significance of Discordant Serology in Chagas Disease: Enhanced T-Cell Immunity to in Serodiscordant Subjects.
Frontiers in immunology , 2017 | Pubmed ID: 28966620
Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins.
mBio 11, 2017 | Pubmed ID: 29114029
Spontaneous dormancy protects during extended drug exposure.
eLife 03, 2018 | Pubmed ID: 29578409
Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection.
PLoS pathogens 11, 2018 | Pubmed ID: 30419010
Drug Discovery for Kinetoplastid Diseases: Future Directions.
ACS infectious diseases 02, 2019 | Pubmed ID: 30543391
Protozoan persister-like cells and drug treatment failure.
Nature reviews. Microbiology 10, 2019 | Pubmed ID: 31444481
Chagas Disease Drug Discovery: Multiparametric Lead Optimization against in Acylaminobenzothiazole Series.
Journal of medicinal chemistry 11, 2019 | Pubmed ID: 31657555
New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: Clinical, Parasitological, and Serological Assessment after Three Years of Follow-Up.
Antimicrobial agents and chemotherapy 08, 2020 | Pubmed ID: 32571827
Cutting Edge: Augmenting Muscle MHC Expression Enhances Systemic Pathogen Control at the Expense of T Cell Exhaustion.
Journal of immunology (Baltimore, Md. : 1950) 08, 2020 | Pubmed ID: 32591392
A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease.
Science translational medicine 10, 2020 | Pubmed ID: 33115952
Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease.
PLoS pathogens 01, 2021 | Pubmed ID: 33508020
A flexible, pan-species, multi-antigen platform for the detection and monitoring of SARS-CoV-2-specific antibody responses.
medRxiv : the preprint server for health sciences Jan, 2021 | Pubmed ID: 33532799
Reduced Trypanosoma cruzi-specific humoral response and enhanced T cell immunity after treatment interruption with benznidazole in chronic Chagas disease.
The Journal of antimicrobial chemotherapy 05, 2021 | Pubmed ID: 33693664
High variation in immune responses and parasite phenotypes in naturally acquired Trypanosoma cruzi infection in a captive non-human primate breeding colony in Texas, USA.
PLoS neglected tropical diseases 03, 2021 | Pubmed ID: 33788859
JoVE 소개
Copyright © 2024 MyJoVE Corporation. 판권 소유