Simon M. Hughes

MyoD protein is differentially accumulated in fast and slow skeletal muscle fibres and required for normal fibre type balance in rodents.

Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog.

The role of hedgehog proteins in vertebrate slow and fast skeletal muscle patterning.

Myogenin induces a shift of enzyme activity from glycolytic to oxidative metabolism in muscles of transgenic mice.

Muscular expressions: profiling genes in complex tissues.

Aging-related satellite cell differentiation defect occurs prematurely after Ski-induced muscle hypertrophy.

Acridine mutagenesis of zebrafish (Danio rerio).

Intermediate filament-co-localized molecules with myosin heavy chain epitopes define distinct cellular domains in hair follicles and epidermis.

Muscle differentiation: a gene for slow muscle?

Hedgehog regulation of superficial slow muscle fibres in Xenopus and the evolution of tetrapod trunk myogenesis.

Hedgehog can drive terminal differentiation of amniote slow skeletal muscle.

The kinase domain of titin controls muscle gene expression and protein turnover.

Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish.

Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy.

Comparison of neurolin (ALCAM) and neurolin-like cell adhesion molecule (NLCAM) expression in zebrafish.

Signals and myogenic regulatory factors restrict pax3 and pax7 expression to dermomyotome-like tissue in zebrafish.

The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues and old isoforms.

Mef2s are required for thick filament formation in nascent muscle fibres.

Mrf4 (myf6) is dynamically expressed in differentiated zebrafish skeletal muscle.

Vestigial-like-2b (VITO-1b) and Tead-3a (Tef-5a) expression in zebrafish skeletal muscle, brain and notochord.

Dystrobrevin and dystrophin family gene expression in zebrafish.

MyoD- and nerve-dependent maintenance of MyoD expression in mature muscle fibres acts through the DRR/PRR element.

Development of mandibular, hyoid and hypobranchial muscles in the zebrafish: homologies and evolution of these muscles within bony fishes and tetrapods.

Sequential actions of Pax3 and Pax7 drive xanthophore development in zebrafish neural crest.

Nerve-dependent changes in skeletal muscle myosin heavy chain after experimental denervation and cross-reinnervation and in a demyelinating mouse model of Charcot-Marie-Tooth disease type 1A.

Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin.

Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic, cranial and fin muscle fibre populations.

Other model organisms for sarcomeric muscle diseases.

Cdkn1c drives muscle differentiation through a positive feedback loop with Myod.

Defective cranial skeletal development, larval lethality and haploinsufficiency in Myod mutant zebrafish.

Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation.

Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion.

Notch signalling is required for the formation of structurally stable muscle fibres in zebrafish.

eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation.

Anaesthetic tricaine acts preferentially on neural voltage-gated sodium channels and fails to block directly evoked muscle contraction.

In vivo dynamics of skeletal muscle Dystrophin in zebrafish embryos revealed by improved FRAP analysis.

Cellular dynamics of regeneration reveals role of two distinct Pax7 stem cell populations in larval zebrafish muscle repair.

The Cannabinoid Receptor Interacting Proteins 1 of zebrafish are not required for morphological development, viability or fertility.

CRISPR/Cas9 editing reveals novel mechanisms of clustered microRNA regulation and function.

Myotome adaptability confers developmental robustness to somitic myogenesis in response to fibre number alteration.

Mef2 and the skeletal muscle differentiation program.

Myogenin promotes myocyte fusion to balance fibre number and size.

Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish.

EGF receptor (EGFR) inhibition promotes a slow-twitch oxidative, over a fast-twitch, muscle phenotype.

Maternal Larp6 controls oocyte development, chorion formation and elevation.

Fgf-driven Tbx protein activities directly induce and to initiate zebrafish myogenesis.

Myogenin is an essential regulator of adult myofibre growth and muscle stem cell homeostasis.

Circadian regulation of muscle growth independent of locomotor activity.

Mef2c factors are required for early but not late addition of cardiomyocytes to the ventricle.

Cellular and molecular pathways controlling muscle size in response to exercise.

Knockout of zebrafish desmin genes does not cause skeletal muscle degeneration but alters calcium flux.

mRNP granule proteins Fmrp and Dcp1a differentially regulate mRNP complexes to contribute to control of muscle stem cell quiescence and activation.

Isolation of Myofibres and Culture of Muscle Stem Cells from Adult Zebrafish.